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Zalicus Presents Data on Oncology Research at ASCO-NCI-EORTC Meeting

Systematic Combination Screening Exploits Differences in Tumor Networks to Identify Context-specific Cytotoxicity

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Oct 19, 2010 - Zalicus Inc. (NASDAQ: ZLCS) presented data today on its research regarding novel synergistic drug combinations for the treatment of cancer at the ASCO-NCI-EORTC Molecular Markers meeting in Hollywood, FL on October 19, 2010. The poster entitled “Systematic Combination Screening Exploits Tumor Biology Networks to Create Context-specific Cytotoxicity”, Short,, explores the association of cancer cell line genotype to combination drug sensitivity as a predictor of synergy and potentially responsive patient populations.

Dr. Short and the Zalicus research team confirmed that broad synergy profiling, as opposed to single-agent response data, is required to maximally exploit drug synergy. Specifically, the team has demonstrated that temporal sequencing of drug combinations can yield greater synergy and overcome resistant phenotypes thereby increasing the probability of context-specific cytotoxicity. Importantly, this work establishes that correlating chemo-sensitivity and genomic determinants can be leveraged to identify potentially responsive patient populations.

“These data, which were generated with our combination high-throughput screening (cHTS™) technology, are in alignment with the goals of our Novartis oncology collaboration whereby we can begin to associate drug sensitivity to genotype and in so doing, identify patient populations that may benefit from any given combination therapy,” commented Mark H.N. Corrigan, M.D., President and CEO of Zalicus Inc.

About Zalicus

Zalicus Inc. (NASDAQ: ZLCS) is a biopharmaceutical company that discovers and develops novel treatments for patients suffering from pain and immuno-inflammatory diseases. Zalicus applies its selective ion-channel modulation platform and its combination high throughput screening capabilities to discover innovative therapeutics for itself and its collaborators in the areas of pain, inflammation, oncology and infectious disease. To learn more about Zalicus, please visit

Forward-Looking Statement

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 concerning Zalicus, Zalicus' combination drug discovery technology, cHTS, and its other business plans. These forward-looking statements about future expectations, plans, objectives and prospects of Zalicus may be identified by words like "believe," "expect," "may," "will," "should," "seek," “plan” or “could” and similar expressions and involve significant risks, uncertainties and assumptions, including risks related to the development and regulatory approval of Zalicus's product candidates, the unproven nature of the Zalicus drug discovery technologies, and those other risks that can be found in the "Risk Factors" section of Zalicus's annual report on Form 10-K on file with the Securities and Exchange Commission and the other reports that Zalicus periodically files with the Securities and Exchange Commission. Actual results may differ materially from those Zalicus contemplated by these forward-looking statements. These forward looking statements reflect management's current views and Zalicus does not undertake to update any of these forward-looking statements to reflect a change in its views or events or circumstances that occur after the date of this release except as required by law.

(c) 2010 Zalicus Inc. All rights reserved.

Contact: Zalicus Inc.
Justin Renz, 617-301-7575
Gina Nugent, 857-753-6562



Posted: October 2010