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RIFM Respiratory Science Program Manager Authors Book on Nanoparticles and Lung Effects

WOODCLIFF LAKE, N.J., June 24, 2011 /PRNewswire-USNewswire/ -- Madhuri Singal, Ph.D., RRT, Manager, of the Respiratory Science Program at the Research Institute for Fragrance Materials, Inc. (RIFM), has authored a research volume on nanoparticles and lung effects. Published by VDM Verlag Dr. Mueller, Nanoparticle Induced Inflammatory Signaling in the Lung: Mechanism of Aerosil200 Particulate Induced Inflammatory Gene Expression in Alveolar Epithelial Cells can now be purchased through the RIFM Online Store at The research detailed in this book provides a possible mechanism by which particle-induced signaling in alveolar Type II epithelial lung cells may occur when exposed to nanosized silica particles. With the advent of nanoparticle technology, in industrial and consumer products, toxicological assessment of Aerosil200 particles may become a standard against which to measure the effects of other nanoparticles.



RIFM President, Dr. Ladd Smith commented, "We are pleased that Dr. Singal's previous work is now available and look forward to the use of similar mechanistic research in the RIFM respiratory program, as we develop alternative methods for safety assessment." At RIFM, Dr. Singal developed a comprehensive 5-year research plan designed to systematically address critical questions regarding fragrance material safety and any impact on airway hypersensitivity or respiratory allergy development. More information on RIFM's Respiratory Science Program is available from the RIFM web site at or by e-mailing

In addition to her research at RIFM, Dr. Singal is an active member of the American Association for Respiratory Care, the National Board for Respiratory Care, the Society of Toxicology, and the American Thoracic Society.

RIFM is the international scientific authority for the safe use of fragrance materials. RIFM generates, evaluates and distributes scientific data on the safety assessment of fragrance raw materials found in personal and household care products. Through extensive research, testing and constant monitoring of all scientific literature available, RIFM maintains its Database as the most comprehensive source worldwide of physical-chemical, toxicological and eco-toxicological data associated with known fragrance and flavor materials. RIFM's scientific findings are evaluated by an independent Expert Panel—an international group of dermatologists, pathologists, toxicologists, respiratory, reproductive and environmental scientists. The Expert Panel evaluates the safety of fragrance ingredients under conditions of intended use and publishes the results in peer-reviewed scientific journals. The decisions of the Expert Panel regarding restrictions of use are also published as IFRA Standards, publicly available from the International Fragrance Association (IFRA) web site at For more information about RIFM and its activities, visit or e-mail

Contact: Marie Gartshore, Communications Manager
tel: 201.689.8089

SOURCE Research Institute for Fragrance Materials, Inc.

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Posted: June 2011

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