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Phase 2 Data on Provectus's PV-10 To Be Presented at the 2010 ASCO Scientific Program on June 4 - 8 in Chicago

KNOXVILLE, Tenn.--(BUSINESS WIRE)--Mar 18, 2010 - Provectus Pharmaceuticals, Inc. (OTC BB: PVCT), a development-stage oncology and dermatology biopharmaceutical company, announced today that data from its Phase 2 study of PV-10 for metastatic melanoma has been accepted for presentation at the 2010 American Society of Clinical Oncology (ASCO) Scientific Program to be held on June 4 – 8, 2010 in Chicago, Illinois.


Dr. Sanjiv Agarwala, Chief, Medical Oncology and Hematology at St. Luke's Hospital and Health Network in Bethlehem, PA, and Principal Investigator for Provectus's Phase 2 PV-10 trial site at St. Luke's, will present Abstract #8534, entitled “Chemoablation of metastatic melanoma with rose bengal (PV-10),” in the General Poster Session.


Dr. Agarwala said, “With enrollment of all 80 subjects this multi-center Phase 2 trial completed in May 2009, I look forward to presenting a comprehensive update on PV-10 for treatment of metastatic melanoma. As I recently noted, PV-10 is intriguing to me as an oncologist because it appears to recruit immune cells to the ablation site, leading to the potential of a systemic benefit.”


Craig Dees, PhD, CEO of Provectus said, “We look forward to Dr. Agarwala's presentation, which marks another milestone for the continued research and development of PV-10 as we gain more momentum in our fight against cancer. Metastatic melanoma is a dreadful and deadly disease, and we believe PV-10 holds promise as a viable, safe and effective treatment, with minimal side effects, not only for this disease, but potentially for a broad spectrum of other cancers as well.”


About PV-10


PV-10 is a proprietary, injectable formulation of Rose Bengal, a compound that has been in use for nearly thirty years by ophthalmologists to assess damage to the eye. It has also been used as an intravenous diagnostic to detect ailments of the liver. Rose Bengal is a small molecule agent with an established safety history, a short half-life in the bloodstream, and is excreted via the liver and kidneys. Provectus has discovered a novel use for Rose Bengal based on the observation that it is selectively toxic to cancer calls via a process called chemoablation whereby cells undergo a form of cell death that mimics both features of necrosis and apoptosis.


About Provectus Pharmaceuticals, Inc. (


Provectus Pharmaceuticals specializes in developing oncology and dermatology therapies. Its lead oncology agent, PV-10, is designed to selectively target and destroy cancer cells without harming surrounding healthy tissue, significantly reducing systemic side effects. Its oncology focus is on melanoma, breast cancer and metastatic liver cancer. The Company has received orphan drug designation from the FDA for its melanoma indication. Its lead dermatological drug, PH-10, also targets abnormal or diseased cells, with the current focus on psoriasis and atopic dermatitis. Provectus has recently completed enrollment in three of its Phase 2 trials -- PV-10 as a therapy for metastatic melanoma, and PH-10 as a topical treatment for atopic dermatitis and for psoriasis. It has also recently initiated a Phase 1 trial for PV-10 for liver cancer. Information about these and the Company's other clinical trials can be found at the NIH registry, For additional information about Provectus please visit the Company's website at or contact Porter, LeVay & Rose, Inc.


FORWARD-LOOKING STATEMENTS: The forward-looking statements contained herein are subject to certain risks and uncertainties that could cause actual results to differ materially from those reflected in the forward-looking statements. Readers are cautioned not to place undue reliance on these forward-looking statements, which reflect management's analysis only as of the date hereof. The company undertakes no obligation to publicly revise these forward-looking statements to reflect events or circumstances that arise after the date thereof.



Contact: Provectus Pharmaceuticals, Inc.

Peter R. Culpepper, CFO, COO

866-594-5999 #30


Porter, LeVay & Rose, Inc.

Marlon Nurse, VP – Investor Relations

Bill Gordon, SVP – Media Relations




Posted: March 2010