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InvestBio Portfolio Company Presents Phase I/II Trial Results of Vaccine for Leukemia at American Society of Hematology Annual Meeting

NEW YORK--(BUSINESS WIRE)--Feb 29, 2008 - Results from a clinical study using technology licensed by The Vaccine Company (TVC), an InvestBio, Inc. portfolio company, were presented at the 49th Annual Meeting of the American Society of Hematology.

The company's PR1 peptide vaccine is derived from two proteins that are either overexpressed or aberrantly expressed in certain cancer cells. Administration of the PR1 vaccine to some patients elicits the proliferation of, PR1-specific cytotoxic T lymphocytes that selectively kill three types of leukemia - myelodysplastic syndrome, acute myelogenous leukemia and chronic myelogenous leukemia.

In the Phase I/II study, the median time in remission for leukemia patients who responded to the PR1 vaccine was three times longer than for non-responders. The Phase I/II clinical trial ran from 2000 to 2006 and was designed to assess the vaccine's safety and ability to elicit an immune response. TVC is now conducting a Pivotal Phase III clinical trial with the vaccine to treat acute myelogenous leukemia.

The PR1 vaccine was developed by Jeffrey Molldrem, M.D., professor at The University of Texas M.D. Anderson Cancer Center. Dr. Molldrem co-founded TVC in 2003, and the company licensed the technology from M.D. Anderson in 2004. M.D. Anderson has an equity interest in TVC.

"Dr. Molldrem's positive results with the PR1 vaccine as reported at ASH gave us confidence to invest in follow-on Phase III and Phase II clinical trials of the vaccine. Early results are validating that confidence," said Gregory Thayer, President & CEO of The Vaccine Company. "We're delighted by the responses that The Vaccine Company was able to present," said Scott Mathis, founder and head of InvestBio and its parent company, Diversified Private Equity Corp. (DPEC Partners). InvestBio creates opportunities for accredited investors to participate in private equity investments in promising biotech companies. InvestBio has raised $20 million for TVC. Mr. Mathis serves on the TVC board of directors.

For more information, please contact Alexandra Corriveau at Sommerfield Communications, Inc. at 212-255-8386 or

About InvestBio and DPEC Partners

InvestBio, Inc., is a subsidiary of Diversified Private Equity Corp. (DPEC Partners) that focuses on identifying and forming investment vehicles that enable accredited investors to participate in private equity investments in promising biotech companies. DPEC Partners is an integrated company whose businesses bring entrepreneurial, private equity and institutional-quality investments to accredited investors in the U.S.

About The Vaccine Company

The Vaccine Company, a Delaware corporation formed in 2003, was founded to commercialize the PR1 vaccine developed at the M.D. Anderson Cancer Center at the University of Texas. The Vaccine Company has an exclusive worldwide license from the M.D. Anderson Cancer Center. The license includes exclusive rights to other potential peptide vaccines, which the company intends to advance to clinical trials.


Sommerfield Communications
Alexandra Corriveau, 212-255-8386

Posted: February 2008