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Chroma to Present Phase I Efficacy Data for Novel Cancer Therapy CHR-2797

OXFORD, England, November 30, 2007 /PRNewswire/ -- Chroma Therapeutics Limited announced today that it will report efficacy data from a Phase I clinical trial of its oral, once-daily experimental cancer therapy CHR-2797 at the forthcoming American Society of Hematology (ASH) meeting. CHR-2797 is the only oral aminopeptidase inhibitor currently in clinical development. The company will also be presenting the results of various preclinical studies. Details of the presentations are as follows:

     Abstract # 443: oral presentation

     Title: A Phase I Study of CHR-2797, an Orally Active Aminopeptidase

      Inhibitor in Elderly and/or Treatment Refractory Patients with Acute

      Myeloid Leukemia

     Location and timing: Acute Myeloid Leukemias: Therapy, excluding

      Transplantation-Novel Therapies, Rooms A411-A412: Monday December 10,

      2007, 13:30-15:00 Eastern Standard Time

     Presenter: Dr Faith Davies (Royal Marsden Hospital, London, UK)

     Abstract # 1608, Poster # 762

     Title: Cellular Aminopeptidase Inhibition as a Target for the Therapy of

      AML by the Novel Agent CHR-2797

     Location and timing: Poster Session I, Hall B4: Saturday, December 8,

      2007, 17:30-19:30 Eastern Standard Time

     Presenter: Dr Chris Jenkins (University Hospital, Cardiff, UK)

     Abstract # 2505, Poster # 695

     Title: Aminopeptidase Inhibition as a Targeted Treatment Strategy in


     Location and timing: Poster Session II, Hall B4: Sunday, December 9,

      2007, 18:00-20:00, Eastern Standard Time

     Presenter: Dr Faith Davies (Royal Marsden Hospital, London, UK)

The ASH posters will be available at the company's website, following the above presentations.


     Chroma Therapeutics Limited

     Ian Nicholson      Chief Executive Officer      +44 (0)1235 829120

     Richard Bungay     Chief Financial Officer


     Jon Coles                                       +44 (0)20 7404 5959

     Justine McIlroy

About aminopeptidases and CHR-2797

Aminopeptidases are a family of intracellular enzymes involved in the supply of amino acids that are essential for cell growth. Inhibition of aminopeptidases has been shown to halt cell growth or cause apoptosis (cell death) in a large number of cancer cell lines. Conversely, normal (non-tumour) cell lines have been shown to be insensitive to aminopeptidase inhibition. CHR-2797 is a potent inhibitor of aminopeptidases that has demonstrated strong preclinical efficacy as monotherapy and has also been shown to strongly synergise with a number of leading cancer therapies in a range of cancer cells.

About Chroma Therapeutics

Chroma Therapeutics, based in Oxford (UK), is a drug discovery and development company focused in the fields of oncology and inflammatory disorders. Chroma is building a broad pipeline of first- or best-in-class treatments utilising its expertise in chromatin biology and its novel intracellular accumulation technologies, which include the ability to selectively target drugs to macrophages. Chroma is backed by a number of leading specialist investors, including Abingworth, Essex Woodlands, Gilde, Nomura Phase4 and The Wellcome Trust.

More information about Chroma can be found at

CONTACT: Ian Nicholson, Chief Executive Officer, or Richard Bungay, ChiefFinancial Officer, +44-0-1235-829120, both of Chroma Therapeutics Limited;or Jon Coles or Justine McIlroy, +44-0-20-7404-5959, both of Brunswick, forChroma Therapeutics Limited

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Posted: November 2007