Skip to Content

Amarantus Reports Positive Data in Parkinson's Program

Key Pre-Clinical Result Confirms Findings From Published Literature

SUNNYVALE, CA--(Marketwire - Jul 26, 2011) - Amarantus BioSciences, Inc. (OTCBB: AMBS), a biotechnology company developing MANF, a first-in-class, disease-modifying therapeutic protein that addresses an underlying form of cell death known as apoptosis, announced positive results from a pre-clinical experiment demonstrating that MANF significantly reduces the behavioral deficits caused by the neurotoxin 6-OHDA in a standard animal model of Parkinson's disease. The experiments were funded by a research grant from the Michael J. Fox Foundation for Parkinson's Research and presented at a meeting of the Company's Scientific Advisory Board ("SAB") on April 29, 2011, confirming data previously reported in The Journal of Neuroscience on July 29, 2009.

"The data sets presented at the SAB meeting in April, combined with peer-reviewed data reported in the scientific literature, demonstrate that MANF is a powerful neuroprotectant that prevents the loss of neuronal viability and function from injury in cellular and rodent models of Parkinson's disease," said Eugene M. Johnson PhD, current Amarantus scientific advisor and Professor of Neurology and of Developmental Biology at Washington University School of Medicine, St. Louis. "The breadth of data reported to date, taken together with these new results, indicates that Amarantus has a sound basis to further investigate MANF as a disease-modifying therapeutic protein drug candidate in the MPTP non-human primate model of Parkinson's disease."

"Since 2003, 14 papers have been published in highly-respected peer-reviewed journals describing MANF's ability to rescue neurons from death in a variety of cellular and animal models of CNS disease," said John W. Commissiong PhD, Chief Scientific Officer of Amarantus who discovered MANF. "The data presented at the SAB meeting confirms critical aspects of that work and will allow the Company to focus the MANF Parkinson's development program on the required protocols to gain regulatory approval to initiate human clinical studies."

"We are very encouraged by the data set presented at the April SAB meeting," said Martin D. Cleary, Chairman and Chief Executive Officer of Amarantus. "Parkinson's disease is the centerpiece of Amarantus' internal CNS development effort and meeting this critical milestone internally validates the published literature which describes MANF's broad anti-apoptosis potential, while adding value to the extensive MANF intellectual property portfolio the Company owns and is actively prosecuting to treat CNS and other disease categories. We will now focus our CNS efforts on the advancement of the MANF product development program for Parkinson's disease by executing the protocols required to gain Investigational New Drug status with the FDA."

About Amarantus BioSciences, Inc.
Amarantus BioSciences, Inc. is engaged in the research and development of first-in-class disease-modifying treatments that address the underlying cause of cell death, known as apoptosis, associated with a wide range of diseases. The Company's most advanced product candidate, MANF, is a therapeutic protein indicated for the treatment of Parkinson's disease and Myocardial Infarction. Currently incubating at the Parkinson's Institute in Sunnyvale, CA, Amarantus BioSciences is the recipient of a research grant from The Michael J. Fox Foundation for Parkinson's Research. See

Kena Hudson

Chempetitive Group

+1-510-908-0966 | Cell

Chicago + San Diego + London

Adding life to life science marketing. Learn more at

Posted: July 2011