Skip to Content
Get facts about myelofibrosis treatment options here

Zontivity

Generic Name: vorapaxar (VOR-a-PAX-ar)
Brand Name: Zontivity

Do not take Zontivity if you are actively bleeding. Do not take it if you have a history of stroke, "mini-stroke" or transient ischemic attack (TIA), or bleeding in the brain. Zontivity may increase the risk of bleeding, including bleeding in the brain and sometimes fatal bleeding. Discuss any questions or concerns with your doctor.


Zontivity is used for:

Reducing the risk of blood clots that cause certain health problems (eg, heart attack, stroke) in some patients. It may also be used for other conditions as determined by your doctor.

Zontivity is a protease-activated receptor-1 (PAR-1) antagonist. It works by blocking the formation of blood clots.

Do NOT use Zontivity if:

  • you are allergic to any ingredient in Zontivity
  • you have severe liver problems
  • you are taking a medicine to thin your blood (eg, warfarin), boceprevir, carbamazepine, clarithromycin, conivaptan, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, phenytoin, posaconazole, rifampin, ritonavir, saquinavir, St. John's wort, telaprevir, or telithromycin

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zontivity:

Some medical conditions may interact with Zontivity. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have kidney or liver problems
  • if you have a history of bleeding problems or stomach ulcers
  • if you have recently had a serious injury, surgery (eg, open heart surgery, such as coronary artery bypass graft [CABG]), or a procedure to open up blood vessels (percutaneous coronary intervention [PCI])
  • if you are planning to have surgery or a dental procedure

Some MEDICINES MAY INTERACT with Zontivity. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Medicines to break up blood clots (eg, alteplase), medicines to thin your blood (eg, warfarin), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), selective serotonin reuptake inhibitors (SSRIs) (eg, sertraline), or serotonin norepinephrine reuptake inhibitors (SNRIs) (eg, duloxetine) because the risk of bleeding may be increased
  • Boceprevir, clarithromycin, conivaptan, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telaprevir, or telithromycin because they may increase the risk of Zontivity's side effects
  • Carbamazepine, phenytoin, rifampin, or St. John's wort because they may decrease Zontivity's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zontivity may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zontivity:

Use Zontivity as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Zontivity comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Zontivity refilled.
  • Take Zontivity by mouth with or without food.
  • If you miss a dose of Zontivity, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zontivity.

Important safety information:

  • Tell your doctor or dentist that you take Zontivity before you receive any medical or dental care, emergency care, or surgery. You may need to stop Zontivity before you have certain types of surgery or procedures.
  • Do not stop taking Zontivity without talking with the doctor who ordered it for you.
  • Zontivity may reduce the number of clot-forming cells (platelets) in your blood. You may bleed and bruise more easily while you take Zontivity and for about 4 weeks after you stop taking it. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Use Zontivity with caution in the ELDERLY; they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zontivity while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking Zontivity.

Possible side effects of Zontivity:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild bleeding or bruising.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; depression; fainting; one-sided weakness; severe or persistent dizziness; symptoms of bleeding (eg, vomiting blood or vomit that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; any bleeding that is severe or that you cannot stop); unusual tiredness or weakness; vision or speech problems.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Zontivity:

Store Zontivity at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store in the original package. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zontivity out of the reach of children and away from pets.

General information:

  • If you have any questions about Zontivity, please talk with your doctor, pharmacist, or other health care provider.
  • Zontivity is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Zontivity or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Zontivity. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Zontivity. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Zontivity.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

Hide