Generic Name: zolmitriptan (ZOLE-mi-TRIP-tan)
Brand Name: Zomig
Zolmitriptan spray is used for:
Treating migraine headaches with or without aura (flashing lights, wavy lines, dark spots) in adults. It is not intended to prevent migraines.
Zolmitriptan spray is a serotonin 5-HT1 receptor agonist ("triptan"). It works by narrowing blood vessels in the brain, which helps to relieve migraines.
Do NOT use zolmitriptan spray if:
- you are allergic to any ingredient in zolmitriptan spray
- you have certain types of irregular heartbeat (eg, Wolff-Parkinson-White syndrome)
- you have a history of ischemic heart disease (eg, angina, a heart attack), coronary artery disease (CAD), other moderate to severe heart problems, brain blood vessel disease (eg, a stroke, a transient ischemic attack), or other blood vessel disease (eg, Raynaud syndrome, ischemic bowel disease)
- you have uncontrolled or severe high blood pressure or moderate to severe liver problems
- you have certain types of migraines (eg, hemiplegic, basilar, ophthalmoplegic)
- you have used an ergot derivative (eg, ergotamine, dihydroergotamine) or another "triptan" migraine medicine (eg, eletriptan, rizatriptan) in the last 24 hours
- you are currently taking sibutramine
- you are taking or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the past 14 days
Contact your doctor or health care provider right away if any of these apply to you.
Before using zolmitriptan spray:
Some medical conditions may interact with zolmitriptan spray. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of liver or kidney problems, seizures (eg, epilepsy), growths in the brain, heart problems (eg, irregular heartbeat), or other types of headaches (eg, cluster headaches)
- if you have shortness of breath, chest pain, or a history of high blood pressure, high cholesterol, diabetes, or smoking
- if you are a woman who is past menopause
- if you are a male who is older than 40 years old
- if you are very overweight
- if a family member has had heart disease or a stroke
Some MEDICINES MAY INTERACT with zolmitriptan spray. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), serotonin-norepinephrine reuptake inhibitors (SNRIs) (eg, duloxetine), sibutramine, or tricyclic antidepressants (eg, amitriptyline) because the risk of a serious side effect called serotonin syndrome may be increased. Symptoms of serotonin syndrome may include mental or mood changes, hallucinations, fast heartbeat, fever, loss of coordination, muscle spasms, increased sweating, nausea, vomiting, or diarrhea
- Cimetidine, MAOIs (eg, phenelzine), or quinolone antibiotics (eg, ciprofloxacin) because they may increase the risk of zolmitriptan spray's side effects
- Ergot derivatives (eg, ergotamine, dihydroergotamine ) or another "triptan" migraine medicine (eg, eletriptan, rizatriptan) because the risk of their side effects may be increased by zolmitriptan spray
This may not be a complete list of all interactions that may occur. Ask your health care provider if zolmitriptan spray may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use zolmitriptan spray:
Use zolmitriptan spray as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with zolmitriptan spray. Talk to your pharmacist if you have questions about this information.
- It is best to use zolmitriptan spray as soon as you notice the headache symptoms of a migraine attack.
- Avoid spraying zolmitriptan spray into the eyes.
- The protective cap must not be removed from zolmitriptan spray until you are ready to use it.
- Do NOT test the spray before use.
- Gently blow your nose, then sit down and tilt your head back slightly. Spray the prescribed dose into 1 nostril as directed. Breathe gently through your mouth for 5 to 10 seconds. You may feel liquid in your nose or the back of your throat. This is normal and will go away.
- If your migraine symptoms go away and then come back, you may take a second dose as directed by your doctor. Wait at least 2 hours between doses.
- If your symptoms do not get better after the first dose, do not take a second dose for the same attack. Contact your doctor.
- Do NOT take more than the amount prescribed by your doctor in a 24-hour period or treat more than 3 headaches within 30 days without checking with your doctor.
- If your medicine has expired, throw it away.
- If you miss a dose of zolmitriptan spray and you still have a headache, follow your doctor's dosing instructions. Contact your doctor if you are unsure of what to do if you miss a dose. Do NOT use zolmitriptan spray more often than prescribed. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use zolmitriptan spray.
Important safety information:
- Zolmitriptan spray may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use zolmitriptan spray with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Overuse of zolmitriptan spray can cause your headache to become worse. Do NOT take more than the recommended dose or use more often than prescribed without checking with your doctor.
- Rarely, serious heart problems (eg, a heart attack, irregular heartbeat) have been reported within a few hours of using zolmitriptan spray. Contact your doctor at once if fast or irregular heartbeat; chest, jaw, or neck pain or numbness; sudden, severe nausea or vomiting; sudden, unusual sweating or weakness; shortness of breath; fainting; or vision changes occur. Discuss any questions or concerns with your doctor.
- Serotonin syndrome is a possibly fatal syndrome that can be caused by zolmitriptan spray. Your risk may be greater if you take zolmitriptan spray with certain other medicines (eg, SSRIs, SNRIs). Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.
- Zolmitriptan spray should not be used to prevent or reduce the number of migraine headaches you have. If you have a headache that is different than your usual migraine headaches, check with your doctor before using zolmitriptan spray.
- Lab tests, including heart function and blood pressure, may be performed while you use zolmitriptan spray. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use zolmitriptan spray with caution in the ELDERLY; they may be more sensitive to its effects.
- Zolmitriptan spray should not be used in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using zolmitriptan spray while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while using zolmitriptan spray.
Possible side effects of zolmitriptan spray:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Burning, numbness, or tingling of the skin; dizziness; drowsiness; dry mouth; feeling of heaviness or pressure in areas of the body other than the jaw, neck, throat, or chest; nausea or stomach upset; unusual taste; warm or hot sensation; weakness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); bloody diarrhea; confusion; fainting; fast or irregular heartbeat; mental or mood changes; one-sided weakness; pain, tightness, heaviness, or pressure in the jaw, neck, throat, or chest; severe or persistent headache or dizziness; shortness of breath; slurred speech; sudden, severe nausea or vomiting; sudden, unusual sweating or weakness; sudden or severe stomach pain; very cold or blue fingers or toes; vision loss or other vision changes; wheezing.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include unusual drowsiness.Proper storage of zolmitriptan spray:
Store zolmitriptan spray at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep zolmitriptan spray out of the reach of children and away from pets.
- If you have any questions about zolmitriptan spray, please talk with your doctor, pharmacist, or other health care provider.
- Zolmitriptan spray is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take zolmitriptan spray or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about zolmitriptan spray. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to zolmitriptan spray. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using zolmitriptan spray.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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