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Xpovio (100 MG Once Weekly)

Generic Name: Selinexor (SEL i NEX or)
Brand Name: Xpovio (100 MG Once Weekly), Xpovio (60 MG Once Weekly), Xpovio (80 MG Once Weekly), Xpovio (80 MG Twice Weekly)

Medically reviewed by Drugs.com. Last updated on Mar 26, 2019.

Uses of Xpovio:

  • It is used to treat multiple myeloma.

What do I need to tell my doctor BEFORE I take Xpovio?

  • If you have an allergy to Xpovio (100 MG Once Weekly) (selinexor) or any part of Xpovio (100 MG Once Weekly) (selinexor).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you are not able to eat or drink like normal, including before certain procedures or surgery.
  • If you are breast-feeding. Do not breast-feed while you take Xpovio (100 MG Once Weekly) (selinexor) and for 1 week after your last dose.

This is not a list of all drugs or health problems that interact with Xpovio (100 MG Once Weekly) (selinexor).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Xpovio (100 MG Once Weekly) (selinexor) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Xpovio?

  • Tell all of your health care providers that you take Xpovio (100 MG Once Weekly) (selinexor). This includes your doctors, nurses, pharmacists, and dentists.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how Xpovio (100 MG Once Weekly) (selinexor) affects you.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor. Rarely, some bleeding problems have been deadly.
  • You may have more of a chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu. Some infections have been very bad and even deadly.
  • This medicine may cause weight loss. You will need to have your weight checked while taking Xpovio (100 MG Once Weekly) (selinexor). Talk with your doctor.
  • If you are 75 or older, use Xpovio (100 MG Once Weekly) (selinexor) with care. You could have more side effects.
  • This medicine may affect fertility. Fertility problems may lead to not being able to get pregnant or father a child. Talk with the doctor.
  • This medicine may cause harm to an unborn baby. A pregnancy test will be done before you start Xpovio (100 MG Once Weekly) (selinexor) to show that you are NOT pregnant.
  • Women must use birth control while taking Xpovio (100 MG Once Weekly) (selinexor) and for some time after the last dose. Ask your doctor how long to use birth control. If you get pregnant, call your doctor right away.
  • Men with a partner who may get pregnant must use birth control while taking Xpovio (100 MG Once Weekly) (selinexor) and for some time after the last dose. Ask your doctor how long to use birth control. If your partner gets pregnant, call the doctor right away.

How is this medicine (Xpovio) best taken?

Use Xpovio (100 MG Once Weekly) (selinexor) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • This medicine is not taken every day. Be sure you know how to take it. Talk with your doctor if you have questions.
  • Swallow whole with a full glass of water.
  • Do not chew, break, or crush.
  • Keep taking Xpovio (100 MG Once Weekly) (selinexor) as you have been told by your doctor or other health care provider, even if you feel well.
  • If you throw up after taking a dose, do not repeat the dose. Take your next dose at your normal time.
  • You will need to be sure that you are not dehydrated before getting Xpovio (100 MG Once Weekly) (selinexor). Check with your doctor to see if you need to drink extra fluids before getting Xpovio (100 MG Once Weekly) (selinexor).
  • Drink lots of noncaffeine liquids every day unless told to drink less liquid by your doctor.
  • Other drugs may be given before Xpovio (100 MG Once Weekly) (selinexor) to help avoid side effects.

What do I do if I miss a dose?

  • Skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, seizures, not hungry, or very bad upset stomach or throwing up.
  • Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
  • Dizziness or passing out.
  • Feeling confused.
  • Feeling very tired or weak.
  • Shortness of breath.
  • Blurred eyesight.

What are some other side effects of Xpovio?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Feeling tired or weak.
  • Constipation.
  • Signs of a common cold.
  • Trouble sleeping.
  • Change in taste.
  • Headache.
  • It is common to have diarrhea, loss of appetite, nausea, throwing up, or weight loss with Xpovio (100 MG Once Weekly) (selinexor). Long-term diarrhea or throwing up may lead to dehydration. Call your doctor if any of these side effects are very bad, bother you, or do not go away. Call your doctor right away if you have signs of dehydration like dry skin, mouth, or eyes; thirst; fast heartbeat; dizziness; fast breathing; or confusion.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Xpovio?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Xpovio (100 MG Once Weekly) (selinexor), please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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