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WinRho SDF

Generic Name: Rh(D) Immune Globulin (ar aych oh (dee) i MYUN GLOB yoo lin)
Brand Name: HyperRHO S/D, MICRhoGAM Ultra-Filtered Plus, RhoGAM Ultra-Filtered Plus, Rhophylac, WinRho SDF

Medically reviewed on Sep 5, 2018


All products:
  • The chance of blood clots may be raised with WinRho SDF (rh(D) immune globulin). The chance may be higher in older people, if you have to be in a bed or chair for a long time, if you take estrogen products, or if you have certain catheters. Some health problems like thick blood, heart problems, or a history of blood clots raise the chance of having blood clots. Blood clots can happen if you do not have any of these health problems. Call your doctor right away if you have numbness or weakness on 1 side of your body; pain, redness, tenderness, warmth, or swelling in the arms or legs; change in color of an arm or leg; chest pain or pressure; shortness of breath; fast heartbeat; or coughing up blood. Talk with your doctor.
Injection (if given in the vein):
  • Some patients with immune thrombocytopenia (ITP) may have a very bad and sometimes deadly red blood cell reaction. Call your doctor if you have dark urine, back pain, fever, chills, or shaking.
  • Very bad kidney problems, anemia, and other blood problems have also happened. Talk with your doctor.
  • You will be watched closely by your doctor.

Uses of WinRho SDF:

  • It is used to treat Rh hemolytic disease.
  • It is used to treat immune thrombocytopenia (ITP).
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take WinRho SDF?

For all patients taking WinRho SDF (rh(D) immune globulin):

  • If you have an allergy to Rho(D) immune globulin or any other part of WinRho SDF (rh(D) immune globulin).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Anemia, other blood or bleeding problems, or you have had your spleen removed.
  • If you have IgA deficiency.
  • If you have recently had a live vaccine


  • If your child is a newborn. Some brands of WinRho SDF (rh(D) immune globulin) are not for use in newborns.

This is not a list of all drugs or health problems that interact with WinRho SDF (rh(D) immune globulin).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take WinRho SDF (rh(D) immune globulin) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take WinRho SDF?

  • Tell all of your health care providers that you take WinRho SDF (rh(D) immune globulin). This includes your doctors, nurses, pharmacists, and dentists.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how WinRho SDF (rh(D) immune globulin) affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
  • Have your blood work checked. Talk with your doctor.
  • This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take WinRho SDF (rh(D) immune globulin).
  • If you have high blood sugar (diabetes), talk with your doctor about which glucose tests are best to use.
  • This medicine is made from human plasma (part of the blood) and may have viruses that may cause disease. This medicine is screened, tested, and treated to lower the chance that it carries an infection. Talk with the doctor.
  • Do not get any vaccines for 3 months after getting immune globulin without talking with your doctor.
  • If you are 65 or older, use WinRho SDF (rh(D) immune globulin) with care. You could have more side effects.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using WinRho SDF (rh(D) immune globulin) while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (WinRho SDF) best taken?

Use WinRho SDF (rh(D) immune globulin) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as a shot.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Back pain.
  • Belly pain.
  • Blood in the urine.
  • Dark urine or yellow skin or eyes.
  • Not able to pass urine or change in how much urine is passed.
  • Upset stomach or throwing up.
  • Shortness of breath, a big weight gain, or swelling in the arms or legs.
  • Feeling very tired or weak.
  • Fever or chills.
  • Change in color of urine.
  • Very bad dizziness or passing out.
  • Very bad headache.
  • Fast breathing.
  • Pale skin.
  • Any unexplained bruising or bleeding.

What are some other side effects of WinRho SDF?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Headache.
  • Dizziness.
  • Feeling sleepy.
  • Pain where the shot was given.
  • Redness or swelling where the shot is given.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out WinRho SDF?

  • If you need to store WinRho SDF (rh(D) immune globulin) at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about WinRho SDF (rh(D) immune globulin), please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.