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Vitrakvi (Larotrectinib Capsules)

Generic Name: Larotrectinib Capsules (LAR oh TREK ti nib)
Brand Name: Vitrakvi

Medically reviewed by Drugs.com. Last updated on Sep 18, 2019.

Uses of Vitrakvi:

  • It is used to treat cancer.

What do I need to tell my doctor BEFORE I take Vitrakvi?

  • If you have an allergy to Vitrakvi (larotrectinib capsules) or any part of Vitrakvi (larotrectinib capsules).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you take any other drugs (prescription or OTC, natural products, vitamins). There are many drugs that interact with Vitrakvi (larotrectinib capsules), like certain drugs that are used for HIV, infections, or seizures.
  • If you are taking St. John's wort. Do not take St. John's wort with Vitrakvi (larotrectinib capsules). This medicine may not work as well.
  • If you are breast-feeding. Do not breast-feed while you take Vitrakvi (larotrectinib capsules) and for 1 week after your last dose.

This is not a list of all drugs or health problems that interact with Vitrakvi (larotrectinib capsules).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Vitrakvi (larotrectinib capsules) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Vitrakvi?

  • Tell all of your health care providers that you take Vitrakvi (larotrectinib capsules). This includes your doctors, nurses, pharmacists, and dentists.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how Vitrakvi (larotrectinib capsules) affects you.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Avoid grapefruit and grapefruit juice.
  • Use with care in children. Talk with the doctor.
  • If you are a man and have sex with a female who could get pregnant, protect her from pregnancy during treatment and for 1 week after your last dose.
  • If you are a man and your sex partner gets pregnant while you take Vitrakvi (larotrectinib capsules) or within 1 week after your last dose, call your doctor right away.
  • This medicine may cause fertility problems. This may affect being able to have children. Talk with the doctor.
  • This medicine may cause harm to the unborn baby if you take it while you are pregnant.
  • If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting Vitrakvi (larotrectinib capsules). Talk with your doctor.
  • Use birth control that you can trust to prevent pregnancy while taking Vitrakvi (larotrectinib capsules) and for 1 week after your last dose.
  • If you get pregnant while taking Vitrakvi (larotrectinib capsules) or within 1 week after your last dose, call your doctor right away.

How is this medicine (Vitrakvi) best taken?

Use Vitrakvi (larotrectinib capsules) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with or without food.
  • Swallow whole with a drink of water.
  • Do not chew or crush.
  • To gain the most benefit, do not miss doses.
  • Keep taking Vitrakvi (larotrectinib capsules) as you have been told by your doctor or other health care provider, even if you feel well.
  • If you throw up after taking a dose, do not repeat the dose. Take your next dose at your normal time.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is less than 6 hours until the next dose, skip the missed dose and go back to the normal time.
  • Do not take 2 doses at the same time or extra doses.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Feeling confused.
  • Trouble speaking.
  • Dizziness or passing out.
  • Change in balance.
  • A burning, numbness, or tingling feeling that is not normal.
  • Memory problems or loss.
  • Shakiness.
  • Feeling very tired or weak.
  • Swelling in the arms or legs.
  • Shortness of breath.
  • Falls.
  • Low white blood cell counts have happened with Vitrakvi (larotrectinib capsules). This may lead to a higher chance of getting an infection. Call your doctor right away if you have signs of infection like fever, chills, or sore throat.

What are some other side effects of Vitrakvi?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Upset stomach or throwing up.
  • Constipation.
  • Diarrhea.
  • Feeling tired or weak.
  • Cough.
  • Headache.
  • Stuffy nose.
  • Weight gain.
  • Muscle or joint pain.
  • Muscle weakness.
  • Back pain.
  • Pain in arms or legs.
  • Not hungry.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Vitrakvi?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Vitrakvi (larotrectinib capsules), please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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