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Tybost

Generic Name: cobicistat (koe-BIK-i-stat)
Brand Name: Tybost

Tybost is used for:

Boosting the action of certain other medicines used to treat HIV (atazanavir or darunavir).

Tybost is an inhibitor of medicine metabolism. It works by boosting the action of other HIV medicines.

Do NOT use Tybost if:

  • you are allergic to any ingredient in Tybost
  • you are taking another medicine that contains cobicistat
  • you are taking alfuzosin, avanafil, boceprevir, cisapride, dihydroergotamine, dronedarone, ergotamine, etravirine, fosamprenavir, lopinavir, lovastatin, methylergonovine, nevirapine, oral midazolam, pimozide, rifampin, salmeterol, saquinavir, simeprevir, simvastatin, St. John's wort, telaprevir, tipranavir, or triazolam
  • you are taking sildenafil to treat pulmonary arterial hypertension (PAH)
  • you are taking atazanavir and you are also taking indinavir, irinotecan, or nevirapine
  • you are taking darunavir and you are also taking efavirenz
  • you are taking or have recently taken a medicine that may harm your kidneys (eg, an aminoglycoside antibiotic [eg, gentamicin], amphotericin B, cyclosporine, a nonsteroidal anti-inflammatory drug [NSAID] [eg, ibuprofen], tacrolimus, vancomycin). Ask your doctor if you are not sure if any of your medicines might harm your kidneys
  • you are taking colchicine and you also have kidney or liver problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Tybost:

Some medical conditions may interact with Tybost. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have kidney problems
  • if you are taking other medicines to treat HIV. Certain HIV medicines should not be taken together with Tybost. Talk with your doctor.

Some MEDICINES MAY INTERACT with Tybost. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Many prescription and nonprescription medicines (eg, used for abortion, aches and pains, allergies, angina, asthma or other lung or breathing problems, birth control, blood thinning, cancer, cystic fibrosis, depression or other mental or mood problems, diabetes or high blood sugar, erectile dysfunction, gout, hepatitis, high blood pressure, high cholesterol, immune system suppression, infections, inflammation, intermittent claudication, irregular heartbeat or other heart problems, migraines, myelofibrosis, nausea and vomiting, pain, prostate problems, PAH, seizures, sleeping problems, stomach or bowel problems, Tourette syndrome), multivitamin products, and herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort) because they may interact with Tybost. Ask your doctor or pharmacist if you are unsure if any of your medicines might interact with Tybost

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tybost may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Tybost:

Use Tybost as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Tybost by mouth with food.
  • Take Tybost at the same time as the other HIV medicine you take it with (atazanavir or darunavir).
  • When taking Tybost with atazanavir:
    • Do not take an antacid within 2 hours before or after you take Tybost.
    • If you take an H2-receptor antagonist (eg, famotidine) or proton pump inhibitor (PPI) (eg, omeprazole), ask your doctor or pharmacist how to take it with Tybost.
  • Continue to take Tybost even if you feel well. Do not miss any doses.
  • Taking Tybost at the same time each day will help you remember to take it.
  • If you miss a dose of Tybost, take it as soon as possible. If it has been more than 12 hours since a missed dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Tybost.

Important safety information:

  • Keep a list of all the medicines that you take. Make a new list each time medicines are added or stopped. Find out about the combinations of medicines that should not be taken while you are using Tybost. Be sure that each of your health care providers knows all the medicines that you are taking.
  • Do not change your dose of Tybost without checking with your doctor.
  • When your medicine supply is low, get more from your doctor or pharmacist as soon as you can. Do not stop taking Tybost, even for a short period of time. If you do, the virus may grow resistant to the medicine and become harder to treat.
  • Tell your doctor or dentist that you take Tybost before you receive any medical or dental care, emergency care, or surgery.
  • Tybost is not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor.
  • Tybost does not stop the spread of HIV to others through blood or sexual contact. Do not have any kind of sex without protection (eg, latex or polyurethane condoms) if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors. Talk with your health care provider about ways to prevent the spread of HIV to others.
  • Serious kidney problems (eg, kidney failure) have happened in people taking Tybost with another HIV medicine (tenofovir). Discuss any questions or concerns with your doctor.
  • Hormonal birth control (eg, birth control pills) may not work as well while you are using Tybost. To prevent pregnancy, use an extra form of birth control (eg, condoms).
  • Lab tests may be performed while you use Tybost. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tybost while you are pregnant. Tybost is found in breast milk. Mothers infected with HIV should not breast-feed. There is a risk of passing the HIV infection or Tybost to the baby. Do not breast-feed while taking Tybost.

Possible side effects of Tybost:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Nausea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); symptoms of kidney problems (eg, increased or decreased urination, swelling of the feet, ankles, or hands); yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Tybost:

Store Tybost at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store in the original container away from heat, moisture, and light. Do not store in the bathroom. Do not use if the seal on the bottle is broken or missing. Keep Tybost out of the reach of children and away from pets.

General information:

  • If you have any questions about Tybost, please talk with your doctor, pharmacist, or other health care provider.
  • Tybost is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Tybost or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Tybost. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Tybost. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Tybost.

Review Date: November 3, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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