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Triprolidine, Pseudoephedrine, and Codeine

Generic Name: Triprolidine, Pseudoephedrine, and Codeine (trye PROE li deen, soo doe e FED rin, & KOE deen)

  • This medicine has an opioid drug in it. The use of opioid drugs along with a benzodiazepine drug or other drugs that may make you drowsy or slow your actions has led to very bad side effects. Side effects that have happened include slowed or trouble breathing and deaths. Benzodiazepine drugs include drugs like alprazolam, diazepam, and lorazepam. Benzodiazepine drugs are used to treat many health problems like anxiety, trouble sleeping, or seizures. Talk with the doctor.
  • Many drugs interact with triprolidine, pseudoephedrine, and codeine and can raise the chance of side effects like deadly breathing problems. Talk with your doctor and pharmacist to make sure it is safe to use this medicine with all of your drugs.
  • Avoid alcohol or other drugs and natural products that slow your actions.
  • Get medical help right away if you feel very sleepy, very dizzy, or if you pass out. Caregivers or others need to get medical help right away if the patient does not respond, does not answer or react like normal, or will not wake up.
  • Get medical help right away if you have slow breathing, shallow breathing, or trouble breathing.
  • Some children have had very bad and sometimes deadly breathing problems when using codeine after surgery to remove tonsils or adenoids. Do not give to a child younger than 18 years of age who has had surgery to remove tonsils or adenoids. Talk with your child's doctor.

Uses of Triprolidine, Pseudoephedrine, and Codeine:

  • It is used to ease allergy signs.
  • It is used to relieve coughing.
  • It is used to treat nose stuffiness.

What do I need to tell my doctor BEFORE I take Triprolidine, Pseudoephedrine, and Codeine?

For all patients taking triprolidine, pseudoephedrine, and codeine:

  • If you have an allergy to triprolidine, pseudoephedrine, codeine, or any other part of this medicine.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Heart disease or high blood pressure.
  • If you have any of these health problems: Lung or breathing problems like asthma, trouble breathing, or sleep apnea; high levels of carbon dioxide in the blood; or stomach or bowel block or narrowing.
  • If you have a cough with a lot of mucous.
  • If you have a long-term cough caused by smoking or being around smoke, or lung problems like asthma or emphysema.
  • If you have taken certain drugs used for low mood (depression) like isocarboxazid, phenelzine, or tranylcypromine or drugs used for Parkinson's disease like selegiline or rasagiline in the last 14 days. Taking triprolidine, pseudoephedrine, and codeine within 14 days of those drugs can cause very bad high blood pressure.
  • If you are taking any of these drugs: Linezolid or methylene blue.
  • If you are taking any of these drugs: Buprenorphine, butorphanol, nalbuphine, or pentazocine.
  • If you are breast-feeding. Do not breast-feed while you take this medicine.

Children:

  • If your child is younger than 12 years of age. Do not give triprolidine, pseudoephedrine, and codeine to a child younger than 12 years of age.
  • If your child is between 12 and 18 years of age and is overweight.

This is not a list of all drugs or health problems that interact with this medicine.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take triprolidine, pseudoephedrine, and codeine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Triprolidine, Pseudoephedrine, and Codeine?

  • Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists.
  • Do not take more than what your doctor told you to take. Taking more than you are told may raise your chance of very bad side effects.
  • Do not take triprolidine, pseudoephedrine, and codeine for longer than you were told by your doctor.
  • Avoid driving and doing other tasks or actions that call for alertness while you take this medicine. Talk with your doctor.
  • To lower the chance of feeling dizzy or passing out, rise slowly over a few minutes when sitting or lying down. Be careful climbing stairs.
  • This medicine may be habit-forming with long-term use.
  • If you have been taking triprolidine, pseudoephedrine, and codeine on a regular basis and you stop it all of a sudden, you may have signs of withdrawal. Do not stop taking this medicine all of a sudden without calling your doctor. Tell your doctor if you have any bad effects.
  • Do not take triprolidine, pseudoephedrine, and codeine with other strong pain drugs or if you are using a pain patch without talking to your doctor first.
  • This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take this medicine.
  • This medicine may be deadly if it is taken by accident. The chance of death may be higher in children. If triprolidine, pseudoephedrine, and codeine is taken by accident, get medical help right away.
  • If you are 60 or older, use this medicine with care. You could have more side effects.
  • The chance of very bad side effects may be higher in children. This may be more likely to happen in children who have breathing problems. Deadly breathing problems have happened with the use of codeine in some children. Talk with the doctor.
  • Use with care in children. Talk with the doctor.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using triprolidine, pseudoephedrine, and codeine while you are pregnant.
  • Using this medicine for a long time during pregnancy may lead to withdrawal in the newborn baby. This can be life-threatening. Talk with the doctor.

How is this medicine (Triprolidine, Pseudoephedrine, and Codeine) best taken?

Use triprolidine, pseudoephedrine, and codeine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with or without food. Take with food if it causes an upset stomach.
  • Measure liquid doses carefully. Use the measuring device that comes with this medicine. If there is none, ask the pharmacist for a device to measure triprolidine, pseudoephedrine, and codeine.

What do I do if I miss a dose?

  • If you take this medicine on a regular basis, take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.
  • Many times triprolidine, pseudoephedrine, and codeine is taken on an as needed basis. Do not take more often than told by the doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Very bad dizziness or passing out.
  • Chest pain or pressure or a fast heartbeat.
  • Noisy breathing.
  • Feeling very sleepy.
  • Feeling very tired or weak.
  • Feeling confused.
  • Slow heartbeat.
  • A heartbeat that does not feel normal.
  • Hallucinations (seeing or hearing things that are not there).
  • Mood changes.
  • Seizures.
  • Trouble passing urine.
  • Shakiness.
  • Change in eyesight.
  • Very upset stomach or throwing up.
  • Very hard stools (constipation).
  • Very bad belly pain.
  • Trouble controlling body movements.
  • Restlessness.
  • Change in balance.
  • This medicine may cause very bad and sometimes deadly breathing problems. Call your doctor right away if you have slow, shallow, or trouble breathing.

What are some other side effects of Triprolidine, Pseudoephedrine, and Codeine?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Feeling nervous and excitable.
  • Dry mouth.
  • Not able to sleep.
  • Dizziness.
  • Feeling sleepy.
  • Blurred eyesight.
  • Feeling tired or weak.
  • Hard stools (constipation).
  • Upset stomach or throwing up.
  • Sweating a lot.
  • Dry nose.
  • Headache.
  • Belly pain.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Triprolidine, Pseudoephedrine, and Codeine?

  • Store at room temperature.
  • Protect from light.
  • Store in a dry place. Do not store in a bathroom.
  • Keep lid tightly closed.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this medicine, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take triprolidine, pseudoephedrine, and codeine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to triprolidine, pseudoephedrine, and codeine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Review Date: September 6, 2017

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