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Triprolidine/ chlophedianol liquid

Generic Name: triprolidine/chlophedianol (trye-PROE-li-deen/KLOE-fe-DYE-a-nol)
Brand Name: Prohist CF

Triprolidine/ chlophedianol liquid is used for:

Relieving cough and other symptoms, such as runny nose and sneezing, due to colds, hay fever, or allergies. It may also be used for other conditions as determined by your doctor.

Triprolidine/chlophedianol liquid is an antihistamine and cough suppressant combination. The antihistamine works by blocking histamine, which reduces allergy symptoms, such as watery eyes and sneezing. The cough suppressant works in the brain to help decrease the cough reflex.

Do NOT use triprolidine/ chlophedianol liquid if:

  • you are allergic to any ingredient in triprolidine/chlophedianol liquid
  • you are unable to urinate or are having an asthma attack
  • you are taking sodium oxybate (GHB) or you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using triprolidine/ chlophedianol liquid:

Some medical conditions may interact with triprolidine/chlophedianol liquid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a fast, slow, or irregular heartbeat
  • if you have a history of adrenal gland problems (eg, tumor); heart problems; high blood pressure; diabetes; heart blood vessel problems; a stroke; glaucoma or increased pressure in the eyes; a blockage of your stomach, intestines, or bladder; ulcers; trouble urinating; an enlarged prostate; seizures; or an overactive thyroid
  • if you have a history of asthma, chronic cough, lung problems (eg, chronic bronchitis, emphysema), trouble breathing when you sleep (sleep apnea), chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus

Some MEDICINES MAY INTERACT with triprolidine/chlophedianol liquid. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Furazolidone, linezolid, MAOIs (eg, phenelzine), or sodium oxybate (GHB) because the risk of serious side effects, such as severe low blood pressure, severe drowsiness, breathing problems, fever, severe muscle problems, and possibly death, may be increased by triprolidine/chlophedianol liquid

This may not be a complete list of all interactions that may occur. Ask your health care provider if triprolidine/chlophedianol liquid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use triprolidine/ chlophedianol liquid:

Use triprolidine/chlophedianol liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take triprolidine/chlophedianol liquid by mouth with or without food.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • If you miss a dose of triprolidine/chlophedianol liquid and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use triprolidine/chlophedianol liquid.

Important safety information:

  • Triprolidine/chlophedianol liquid may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use triprolidine/chlophedianol liquid with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using triprolidine/chlophedianol liquid; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Do not drink alcohol while you are taking triprolidine/chlophedianol liquid.
  • Do NOT exceed the recommended dose or take triprolidine/chlophedianol liquid for longer than prescribed without checking with your doctor.
  • If your symptoms do not improve within 5 to 7 days, if they become worse, if they go away and then come back, or if new symptoms occur, check with your doctor.
  • If your symptoms occur along with a fever, rash, or persistent headache, check with your doctor.
  • Do not use triprolidine/chlophedianol liquid for cough with a lot of mucus. Do not use for long-term cough (eg, caused by asthma, emphysema, smoking). However, you may use it for these conditions if your doctor tells you to.
  • Triprolidine/chlophedianol liquid may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to triprolidine/chlophedianol liquid. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Triprolidine/chlophedianol liquid may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking triprolidine/chlophedianol liquid for a few days before the tests.
  • Tell your doctor or dentist that you take triprolidine/chlophedianol liquid before you receive any medical or dental care, emergency care, or surgery.
  • Use triprolidine/chlophedianol liquid with caution in the ELDERLY; they may be more sensitive to its effects.
  • Caution is advised when using triprolidine/chlophedianol liquid in CHILDREN; they may be more sensitive to its effects.
  • Triprolidine/chlophedianol liquid should not be used in CHILDREN younger than 6 years without first checking with the child's doctor; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking triprolidine/chlophedianol liquid while you are pregnant. Triprolidine/chlophedianol liquid is found in breast milk. If you are or will be breast-feeding while you take triprolidine/chlophedianol liquid, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of triprolidine/ chlophedianol liquid:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; excitability; headache; loss of appetite; nausea; nervousness or anxiety; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, light-headedness, or headache; tremor; trouble sleeping; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, light-headedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of triprolidine/chlophedianol liquid:

Store triprolidine/chlophedianol liquid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep triprolidine/chlophedianol liquid out of the reach of children and away from pets.

General information:

  • If you have any questions about triprolidine/chlophedianol liquid, please talk with your doctor, pharmacist, or other health care provider.
  • Triprolidine/chlophedianol liquid is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take triprolidine/chlophedianol liquid or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about triprolidine/chlophedianol liquid. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to triprolidine/chlophedianol liquid. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using triprolidine/chlophedianol liquid.

Issue Date: June 3, 2015

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.