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Trastuzumab and Hyaluronidase

Generic Name: Trastuzumab and Hyaluronidase (tras TOOZ ue mab & HYE al ure ON i dase)
Brand Name: Herceptin Hylecta

Medically reviewed by Drugs.com. Last updated on Sep 25, 2019.

Warning

  • This medicine may raise the chance of severe and sometimes deadly heart problems. The chance may be higher if you are using daunorubicin, doxorubicin, epirubicin, idarubicin, or mitoxantrone. The chance may also be higher if you use them after getting trastuzumab and hyaluronidase. Call your doctor right away if you have signs of heart problems. This includes a cough or shortness of breath that is new or worse, swelling of the ankles or legs, an abnormal heartbeat, weight gain of more than 5 pounds in 24 hours, dizziness, or passing out.
  • You will need to have heart function tests while taking trastuzumab and hyaluronidase. Talk with the doctor.
  • Severe lung problems have happened during or within 24 hours after getting trastuzumab and hyaluronidase. Sometimes, lung problems have been deadly. Call your doctor right away if you have lung or breathing problems like trouble breathing, shortness of breath, or a cough that is new or worse.
  • This medicine may cause harm to the unborn baby or loss of the unborn baby if you take it while you are pregnant or if you get pregnant within 7 months after your last dose.
  • Use birth control that you can trust to prevent pregnancy while taking trastuzumab and hyaluronidase and for at least 7 months after stopping trastuzumab and hyaluronidase.
  • If you get pregnant while taking trastuzumab and hyaluronidase or within 7 months after your last dose, call your doctor right away.

Uses of Trastuzumab and Hyaluronidase:

What do I need to tell my doctor BEFORE I take Trastuzumab and Hyaluronidase?

  • If you have an allergy to trastuzumab and hyaluronidase or any part of trastuzumab and hyaluronidase.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have had daunorubicin, doxorubicin, epirubicin, idarubicin, or mitoxantrone before, talk with your doctor.

This is not a list of all drugs or health problems that interact with trastuzumab and hyaluronidase.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take trastuzumab and hyaluronidase with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Trastuzumab and Hyaluronidase?

  • Tell all of your health care providers that you take trastuzumab and hyaluronidase. This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Low white blood cell counts have happened more often in people getting trastuzumab and hyaluronidase with chemo compared to people getting only chemo. Low white blood cell counts may raise the chance of getting an infection. If you have questions, talk with your doctor.
  • If you have had or will be having radiation treatment, talk with your doctor. Worse side effects from radiation treatment have happened with trastuzumab and hyaluronidase.
  • Very bad and sometimes deadly allergic side effects have rarely happened with drugs like this one. Talk with the doctor.
  • If you are 65 or older, use trastuzumab and hyaluronidase with care. You could have more side effects.
  • If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting trastuzumab and hyaluronidase. Talk with your doctor.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Trastuzumab and Hyaluronidase) best taken?

Use trastuzumab and hyaluronidase as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as a shot into the fatty part of the skin.
  • Other drugs may be given before trastuzumab and hyaluronidase to help avoid side effects.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
  • Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Feeling very tired or weak.
  • A burning, numbness, or tingling feeling that is not normal.
  • Low mood (depression).

What are some other side effects of Trastuzumab and Hyaluronidase?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Hair loss.
  • Feeling tired or weak.
  • Not hungry.
  • Belly pain.
  • Headache.
  • Change in taste.
  • Bone or joint pain.
  • Muscle pain.
  • Back pain.
  • Pain in arms or legs.
  • Trouble sleeping.
  • Mouth irritation or mouth sores.
  • Irritation where trastuzumab and hyaluronidase is given.
  • Flushing.
  • Signs of a common cold.
  • Change in nails.
  • Change in skin color.
  • Constipation, diarrhea, throwing up, and upset stomach are common with trastuzumab and hyaluronidase. If these happen, talk with your doctor about ways to lower these side effects. Call your doctor right away if any of these effects bother you, do not go away, or get very bad.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Trastuzumab and Hyaluronidase?

  • If you need to store trastuzumab and hyaluronidase at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about trastuzumab and hyaluronidase, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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