Tositumomab and Iodine I 131 Tositumomab
Generic Name: Tositumomab and Iodine I 131 Tositumomab (toe si TYOO mo mab & EYE oh dyne eye one THUR tee one toe si TYOO mo mab)
Brand Name: Bexxar
- Very bad and sometimes deadly allergic side effects have rarely happened. Talk with your doctor.
- This medicine may have unsafe effects on the bone marrow. The bone marrow may not be able to make cells found in the blood as well as it used to.
Uses of Tositumomab and Iodine I 131 Tositumomab:
- It is used to treat lymphoma.
What do I need to tell my doctor BEFORE I take Tositumomab and Iodine I 131 Tositumomab?
- If you have an allergy to tositumomab, iodine, or any other part of tositumomab and iodine I 131 tositumomab.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have any of these health problems: Low white blood cell count, low platelet count, or very bad anemia.
This is not a list of all drugs or health problems that interact with this medicine.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take tositumomab and iodine I 131 tositumomab with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Tositumomab and Iodine I 131 Tositumomab?
- Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take tositumomab and iodine I 131 tositumomab.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
- Follow what you were told to do by your doctor after leaving the hospital to keep from exposing others to this medicine.
- A very bad bone marrow problem and second cancer have happened with tositumomab and iodine I 131 tositumomab. Talk with the doctor.
- Talk with your doctor before getting any vaccines. Use with this medicine may either raise the chance of an infection or make the vaccine not work as well.
- This medicine may cause you to not be able to get pregnant or father a child. Most of the time, this goes back to normal. Talk with your doctor.
- Use birth control that you can trust during care and for 12 months after care ends.
- If you are a man and have sex with a female who could get pregnant, protect her from pregnancy during care and for 12 months after care ends. Use birth control that you can trust.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking tositumomab and iodine I 131 tositumomab, call your doctor right away.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
How is this medicine (Tositumomab and Iodine I 131 Tositumomab) best taken?
Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given into a vein for a period of time.
- Acetaminophen and diphenhydramine may be given before tositumomab and iodine I 131 tositumomab to lower fever and chills.
- A drug to protect the thyroid gland will be given 24 hours before this medicine and for 2 weeks after getting tositumomab and iodine I 131 tositumomab. Talk with your doctor.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Very bad dizziness or passing out.
- Very upset stomach or throwing up.
- Any unexplained bruising or bleeding.
- Feeling very tired or weak.
- Black, tarry, or bloody stools.
- Chest pain or pressure.
- Pale skin.
- Irritation where the shot is given.
- Shortness of breath.
- Swelling in the arms or legs.
- A big weight loss.
- A skin lump or growth.
- Sweating a lot.
- Throwing up blood or throw up that looks like coffee grounds.
- A wound that does not heal.
What are some other side effects of Tositumomab and Iodine I 131 Tositumomab?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Flu-like signs. These include headache, weakness, fever, shakes, aches, pains, and sweating. Mild pain drugs may help.
- Feeling tired or weak.
- Muscle or joint pain.
- Back pain.
- Hard stools (constipation).
- Belly pain.
- Upset stomach or throwing up.
- Loose stools (diarrhea).
- Not hungry.
- Feeling sleepy.
- Neck pain.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Tositumomab and Iodine I 131 Tositumomab?
- If you need to store this medicine at home, talk with your doctor, nurse, or pharmacist about how to store it.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer Information Use and Disclaimer
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about tositumomab and iodine I 131 tositumomab, please talk with your doctor, nurse, pharmacist, or other health care provider.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about tositumomab and iodine I 131 tositumomab. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using tositumomab and iodine I 131 tositumomab.
Review Date: February 7, 2018
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- Drug class: CD20 monoclonal antibodies
Other brands: Bexxar