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Generic Name: hydrochlorothiazide/timolol (hye-droe-klor-oh-THYE-a-zide/TIM-oh-lole)
Brand Name: Timolide
Do not suddenly stop taking Timolide. Sharp chest pain, irregular heartbeat, and sometimes heart attack may occur if you suddenly stop Timolide. The risk may be greater if you have certain types of heart disease. Your doctor should slowly lower your dose over several weeks if you need to stop taking it. This should be done even if you only take Timolide for high blood pressure. Heart disease is common and you may not know you have it. Limit physical activity while you are lowering your dose. If new or worsened chest pain or other heart problems occur, contact your doctor right away. You may need to start taking Timolide again.
Timolide is used for:
Treating high blood pressure.
Timolide is a beta-blocker and diuretic combination. It works by decreasing the force and slowing down the heartbeat, helping the heart beat more regularly and reducing the amount of work the heart has to do. It also increases the elimination of excessive fluid, which helps to decrease blood pressure.
Do NOT use Timolide if:
- you are allergic to any ingredient in Timolide or to sulfonamide medicines (eg, sulfamethoxazole, probenecid, glyburide)
- you have uncontrolled heart failure, heart block, heart shock, a very slow heart rate, or low blood pressure
- you are unable to urinate or have a history of asthma or severe chronic obstructive pulmonary disease (COPD)
- you are taking other beta-blockers (eg, propranolol), dofetilide, or mibefradil
Contact your doctor or health care provider right away if any of these apply to you.
Before using Timolide:
Some medical conditions may interact with Timolide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of bronchitis, lung disease (eg, COPD), diabetes, gout, an overactive thyroid, heart problems (eg, congestive heart failure), blood vessel problems, pheochromocytoma, lupus, liver disease, kidney problems, or abnormal blood electrolyte (eg, potassium sodium) levels
- if you are having surgery, receiving anesthesia, or you are dehydrated
Some MEDICINES MAY INTERACT with Timolide. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Barbiturates (eg, phenobarbital), cimetidine, clonidine, corticosteroids (eg, prednisone), guanethidine, other beta-blockers (eg, propranolol), or reserpine because they may increase the risk of Timolide's side effects
- Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), phenytoin, or rifampin because they may decrease Timolide's effectiveness
- Antiarrhythmics (eg, disopyramide), calcium channel blockers (eg, verapamil, diltiazem), or cimetidine because side effects, such as slow or irregular heart beat or low blood pressure, may occur
- Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), barbiturates (eg, phenobarbital), chlorpromazine, clonidine, diazoxide, flecainide, mefloquine, mibefradil, narcotics (eg, codeine), or nifedipine because the risk of side effects of both medicines may be increased
- Allopurinol, amantadine, digitalis (eg, digoxin), dofetilide, insulin or other medicines for diabetes (eg, glyburide), ketanserin, lithium, theophylline, or thyroxine because the risk of their side effects may be increased by Timolide
This may not be a complete list of all interactions that may occur. Ask your health care provider if Timolide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Timolide:
Use Timolide as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Timolide by mouth with or without food.
- If you also take cholestyramine or colestipol, do not take them within 1 before or 2 hours after taking Timolide. Check with your doctor if you have questions.
- Timolide may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
- If you miss a dose of Timolide, take the missed dose if you remember the same day. Skip the missed dose if you do not remember the same day. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Timolide.
Important safety information:
- Timolide may cause drowsiness, dizziness, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Timolide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Timolide may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
- Timolide may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Timolide. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
- Tell your doctor or dentist that you take Timolide before you receive any medical or dental care, emergency care, or surgery.
- If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.
- Diabetes patients - Timolide may hide signs of low blood sugar, such as a rapid heartbeat. Be sure to watch for other signs of low blood sugar. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your vision change; give you a headache, chills, or tremors; or make you more hungry. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- Timolide may interfere with certain lab tests, including parathyroid function tests. Be sure your doctor and lab personnel know you are taking Timolide.
- Lab tests, including blood pressure, blood electrolyte levels, and heart rate, may be performed while you use Timolide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Timolide with caution in the ELDERLY; they may be more sensitive to its effects.
- Timolide should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Timolide while you are pregnant. Timolide is found in breast milk. Do not breast-feed while taking Timolide.
Possible side effects of Timolide:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Cough; dizziness; drowsiness; lightheadedness; tiredness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; decreased urination; dry mouth; loss of consciousness; muscle pain or weakness; nausea; slow or irregular heartbeat; swelling of ankles or feet; tremors; unusual thirst or fatigue; vomiting.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include coughing; dizziness; drowsiness; fainting; loss of consciousness; muscular weakness; nausea; seizures; slow heartbeat; trouble breathing; upset stomach; vomiting; weakness.Proper storage of Timolide:
Store Timolide at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Timolide out of the reach of children and away from pets.
- If you have any questions about Timolide, please talk with your doctor, pharmacist, or other health care provider.
- Timolide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about Timolide. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.