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Sonidegib

Generic Name: Sonidegib (soe ni DEG ib)
Brand Name: Odomzo

Warning

  • Use of sonidegib during pregnancy may cause birth defects or death of the unborn baby. You will need to have a pregnancy test to show that you are NOT pregnant before starting this medicine. Talk with the doctor.
  • Use birth control that you can trust to prevent pregnancy while taking sonidegib and for at least 20 months after your last dose.
  • If you are a man and have sex with a pregnant female or a female who can get pregnant, you must use a condom while you take this medicine and for at least 8 months after your last dose. Use a condom even if you have had a vasectomy.

Uses of Sonidegib:

  • It is used to treat skin cancer.

What do I need to tell my doctor BEFORE I take Sonidegib?

  • If you have an allergy to sonidegib or any part of this medicine.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with sonidegib, like certain drugs that are used for HIV, infections, or seizures. There are many drugs that must not be taken with this medicine.
  • If you are taking St. John's wort. Do not take St. John's wort with sonidegib. This medicine may not work as well.
  • If you are breast-feeding. Do not breast-feed while you take this medicine or for 20 months after your last dose.

This is not a list of all drugs or health problems that interact with sonidegib.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Sonidegib?

  • Tell all of your health care providers that you take sonidegib. This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Do not donate blood while taking this medicine and for 20 months after your last dose.
  • Do not donate semen while taking sonidegib and for at least 8 months after your last dose.
  • If you have upset stomach, throwing up, loose stools (diarrhea), or are not hungry, talk with your doctor. There may be ways to lower these side effects.
  • If you are 65 or older, use this medicine with care. You could have more side effects.
  • This medicine may cause menstrual periods to stop in females who can get pregnant. This may affect being able to have children. It is not known if this will go back to normal. Talk with the doctor.
  • If you get pregnant while taking sonidegib or within 20 months after your last dose, call your doctor right away.
  • If you are a woman and you miss a period, have unprotected sex, or think that your birth control has not worked, call your doctor right away.
  • If you are a man and your sex partner gets pregnant while you take this medicine or within 8 months after your last dose, call your doctor right away.
  • If you are a man and have unprotected sex with a female who is or could get pregnant, call your doctor right away.

How is this medicine (Sonidegib) best taken?

Use sonidegib as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take on an empty stomach. Take 1 hour before or 2 hours after meals.
  • To gain the most benefit, do not miss doses.
  • Keep taking this medicine as you have been told by your doctor or other health care provider, even if you feel well.

What do I do if I miss a dose?

  • Skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
  • Feeling very tired or weak.
  • Fever or chills.
  • Sore throat.
  • Muscle spasms and muscle pain happen often with sonidegib. However, these can also be signs of very bad muscle problems. Call your doctor right away if you have new or worse muscle spasms or muscle pain that is new or worse, dark urine, or change in how much urine is passed.

What are some other side effects of Sonidegib?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Hair loss.
  • Change in taste.
  • Feeling tired or weak.
  • Upset stomach or throwing up.
  • Loose stools (diarrhea).
  • Weight loss.
  • Not hungry.
  • Belly pain.
  • Headache.
  • Itching.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Sonidegib?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this medicine, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take sonidegib or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to sonidegib. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Review Date: December 6, 2017

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