Generic Name: Asenapine (a SEN a peen)
Brand Name: Saphris
Medically reviewed by Drugs.com. Last updated on May 23, 2019.
- There is a higher chance of death in older adults who take this medicine (Saphris) for mental problems caused by dementia. Most of the deaths were linked to heart disease or infection. This medicine is not approved to treat mental problems caused by dementia.
Uses of Saphris:
- It is used to treat schizophrenia.
- It is used to treat bipolar problems.
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Saphris?
- If you have an allergy to asenapine or any other part of this medicine (Saphris).
- If you have any of these health problems: Liver problems, low magnesium levels, low potassium levels, or slow heartbeat.
- If you have ever had a long QT on ECG or other heartbeat that is not normal.
- If you are taking any drugs that can cause a certain type of heartbeat that is not normal (prolonged QT interval). There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.
This is not a list of all drugs or health problems that interact with this medicine (Saphris).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine (Saphris) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Saphris?
- Tell all of your health care providers that you take this medicine (Saphris). This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for you to be alert until you see how this medicine (Saphris) affects you.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
- Low white blood cell counts have happened with drugs like this one. This may lead to a higher chance of infection. Rarely, infections have been deadly. Tell your doctor if you have ever had a low white blood cell count. Call your doctor right away if you have signs of infection like fever, chills, or sore throat.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- High blood sugar or diabetes, high cholesterol, and weight gain have happened with drugs like this one. These may raise the chance of heart and brain blood vessel disease.
- Check your blood sugar as you have been told by your doctor.
- Avoid drinking alcohol while taking this medicine (Saphris).
- Talk with your doctor before you use other drugs and natural products that slow your actions.
- Be careful in hot weather or while being active. Drink lots of fluids to stop fluid loss.
- Dizziness, sleepiness, and feeling less stable may happen with this medicine (Saphris). These may lead to falling, which can cause broken bones or other health problems.
- Older adults with dementia taking drugs like this one have had a higher number of strokes. Sometimes these strokes have been deadly. This drug is not approved to treat mental problems caused by dementia. Talk with your doctor.
- If you are 65 or older, use this medicine (Saphris) with care. You could have more side effects.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine (Saphris) while you are pregnant.
- Taking this medicine (Saphris) in the third trimester of pregnancy may lead to uncontrolled muscle movements and withdrawal in the newborn.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
How is this medicine (Saphris) best taken?
Use this medicine (Saphris) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Wash and dry your hands before you take this medicine (Saphris). Do not touch the tablet with wet or damp hands.
- Do not take this medicine (Saphris) out of the blister pack until you are ready to take it. Take this medicine (Saphris) right away after opening the blister pack. Do not store the removed drug for future use.
- Place tablet under the tongue and let dissolve.
- Do not swallow whole. Do not chew, break, or crush.
- Do not eat or drink for at least 10 minutes after taking this medicine (Saphris).
- To gain the most benefit, do not miss doses.
- Keep taking this medicine (Saphris) as you have been told by your doctor or other health care provider, even if you feel well.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
What are some side effects that I need to call my doctor about right away?
- Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
- If you are planning to harm yourself or the want to harm yourself gets worse.
- A heartbeat that does not feel normal.
- Fast or slow heartbeat.
- Shortness of breath.
- Very bad dizziness or passing out.
- Trouble controlling body movements, twitching, change in balance, trouble swallowing or speaking.
- Period (menstrual) changes.
- Enlarged breasts.
- Nipple discharge.
- Not able to get or keep an erection.
- Mouth irritation or mouth sores.
- A very bad and sometimes deadly health problem called neuroleptic malignant syndrome (NMS) may happen. Call your doctor right away if you have any fever, muscle cramps or stiffness, dizziness, very bad headache, confusion, change in thinking, fast heartbeat, heartbeat that does not feel normal, or are sweating a lot.
- Some people may get a severe muscle problem called tardive dyskinesia. This problem may lessen or go away after stopping this medicine (Saphris), but it may not go away. The risk is greater with diabetes and in older adults, especially older women. The risk is greater with longer use or higher doses, but it may also occur after short-term use with low doses. Call your doctor right away if you have trouble controlling body movements or problems with your tongue, face, mouth, or jaw like tongue sticking out, puffing cheeks, mouth puckering, or chewing.
What are some other side effects of Saphris?
- Feeling sleepy.
- Throwing up.
- Numbness or tingling in the mouth.
- Weight gain.
- Not able to sleep.
If OVERDOSE is suspected:
How do I store and/or throw out Saphris?
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this medicine (Saphris), please talk with your doctor, nurse, pharmacist, or other health care provider.
More about Saphris (asenapine)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- 238 Reviews
- Drug class: atypical antipsychotics
- FDA Alerts (2)
- FDA Approval History