Generic Name: salsalate (SAL-sa-late)
Brand Name: Disalcid
Salflex is a nonsteroidal anti-inflammatory drug (NSAID). It may cause an increased risk of serious and sometimes fatal heart and blood vessel problems (eg, a heart attack, stroke). The risk may be greater if you already have heart problems or if you take Salflex for a long time. Do not use Salflex right before or after bypass heart surgery.
Salflex may cause an increased risk of serious and sometimes fatal stomach ulcers and bleeding. Elderly patients may be at greater risk. This may occur without warning signs.
Salflex is used for:
Treating pain and inflammation due to arthritis and rheumatoid arthritis. It may also be used for other conditions as determined by your doctor.
Salflex is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking several different chemical processes within the body that cause pain and inflammation.
Do NOT use Salflex if:
- you are allergic to any ingredient in Salflex
- you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or another NSAID (eg, ibuprofen, celecoxib)
- you have recently had or will be having bypass heart surgery
- you have severe kidney problems
- you are more than 24 weeks pregnant.
- you are taking another salicylate medicine (eg, aspirin)
Contact your doctor or health care provider right away if any of these apply to you.
Before using Salflex:
Some medical conditions may interact with Salflex. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of kidney or liver problems, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)
- if you have a history of swelling or fluid buildup, asthma, growths in the nose (nasal polyps), or mouth inflammation
- if you have high blood pressure, blood disorders (eg, porphyria), bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease (eg, in the brain or heart), or if you are at risk of any of these diseases
- if you have poor health, dehydration or low fluid volume, or low blood sodium levels, or if you smoke, drink alcohol, or have a history of alcohol abuse
Some MEDICINES MAY INTERACT with Salflex. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Anticoagulants (eg, warfarin) because the risk of bleeding may be increased
- Angiotensin-converting enzyme inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Salflex and the risk of kidney problems may be increased
- Other salicylate medicines (eg, aspirin) because they may increase the risk of Salflex's side effects
- Corticosteroids (eg, prednisone), lithium, methotrexate, other NSAIDs (eg, ibuprofen), penicillin, phenytoin, sulfinpyrazone, or thyroid hormones (eg, levothyroxine) the risk of their side effects may be increased by Salflex
This may not be a complete list of all interactions that may occur. Ask your health care provider if Salflex may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Salflex:
Use Salflex as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Salflex by mouth. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.
- Take Salflex with a full glass of water (8 oz [240 mL]) as directed by your doctor.
- If you miss a dose of Salflex, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Salflex.
Important safety information:
- Tell your doctor or dentist that you take Salflex before you receive any medical or dental care, emergency care, or surgery.
- Serious stomach ulcers or bleeding can occur with Salflex. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Salflex with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.
- Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
- A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
- Salflex is an NSAID. Before you start any new medicine, check the label to see if it has an NSAID (eg, ibuprofen) in it too. If it does or if you are not sure, check with your doctor or pharmacist.
- Do not take aspirin while you are taking Salflex unless your doctor tells you to.
- Severe and sometimes fatal liver problems have happened with Salflex. Discuss any questions or concerns with your doctor.
- Do not give to children and teenagers who have or are getting better from flu signs, chickenpox, or other viral infections due to the chance of Reye syndrome. Reye syndrome causes very bad problems to the brain and liver.
- You may need to have your blood pressure checked often. Talk with your doctor.
- Salflex may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Salflex.
- Lab tests may be performed if you use Salflex for a long time. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Salflex with caution in the ELDERLY; they may be more sensitive to its effects, especially stomach or bowel bleeding and kidney problems.
- PREGNANCY and BREAST-FEEDING: Salflex may cause harm to the fetus. Do not take it if you are more than 24 weeks pregnant. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Salflex while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use Salflex, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Salflex:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); black, bloody, or tarry stools; blood in the urine; change in the amount of urine produced; chest pain; confusion; fainting; hearing loss; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; severe or persistent dizziness or headache; severe or persistent stomach pain; shortness of breath; sudden or unexplained weight gain; swelling of the hands, legs, or feet; symptoms of liver problems (eg, dark urine, flu-like symptoms, pale stools, persistent loss of appetite, yellowing of the skin or eyes); unusual bruising or bleeding; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Salflex:
Store Salflex at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Salflex out of the reach of children and away from pets.
- If you have any questions about Salflex, please talk with your doctor, pharmacist, or other health care provider.
- Salflex is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Salflex or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Salflex. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Salflex. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Salflex.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about Salflex (salsalate)
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- Drug class: salicylates