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Rolapitant Injection

Generic Name: Rolapitant Injection (roe LA pi tant)
Brand Name: Varubi

Medically reviewed: April 4, 2018

Uses of Rolapitant Injection:

  • It is used to prevent upset stomach and throwing up from chemo.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Rolapitant Injection?

  • If you have an allergy to rolapitant injection or any part of rolapitant injection.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have liver disease.
  • If you are taking any of these drugs: Pimozide, rifampin, or thioridazine.

This is not a list of all drugs or health problems that interact with rolapitant injection.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take rolapitant injection with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Rolapitant Injection?

  • Tell all of your health care providers that you take rolapitant injection. This includes your doctors, nurses, pharmacists, and dentists.
  • Allergic reactions have happened with rolapitant injection. Sometimes, these have been very bad and people have had to go to the hospital. Talk with the doctor.
  • This medicine interacts with many other drugs. This may happen for at least 28 days after you take rolapitant injection. The chance of side effects may be raised. Some side effects may be very bad or life-threatening. Check with your doctor and pharmacist to make sure that it is safe for you to take rolapitant injection with all of your other drugs (prescription or OTC, natural products, vitamins).
  • This medicine may cause fertility problems. This may affect being able to have children. Talk with the doctor.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using rolapitant injection while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Rolapitant Injection) best taken?

Use rolapitant injection as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as an infusion into a vein over a period of time.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

For all patients taking rolapitant injection:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Flushing.
  • Stomach cramps.
  • Belly pain.
  • Throwing up.
  • Back pain.
  • Chest pain.
  • Very bad dizziness or passing out.

People who take rolapitant injection with cisplatin chemo:

  • Low white blood cell counts have happened with rolapitant injection. This may lead to a higher chance of getting an infection. Call your doctor right away if you have signs of infection like fever, chills, or sore throat.

People who take rolapitant injection with other chemo drugs:

  • Signs of a urinary tract infection (UTI) like blood in the urine, burning or pain when passing urine, feeling the need to pass urine often or right away, fever, lower stomach pain, or pelvic pain.
  • Feeling very tired or weak.
  • Low white blood cell counts have happened with rolapitant injection. This may lead to a higher chance of getting an infection. Call your doctor right away if you have signs of infection like fever, chills, or sore throat.

What are some other side effects of Rolapitant Injection?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

People who take rolapitant injection with cisplatin chemo:

People who take rolapitant injection with other chemo drugs:

  • Not hungry.
  • Dizziness.
  • Upset stomach.
  • Mouth sores.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Rolapitant Injection?

  • If you need to store rolapitant injection at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about rolapitant injection, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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