Rituximab and Hyaluronidase
Generic name: Rituximab and Hyaluronidase (ri TUK si mab & hye al yoor ON i dase)
Brand name: Rituxan Hycela
Drug class: CD20 monoclonal antibodies
Medically reviewed by Drugs.com. Last updated on Nov 11, 2020.
- A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
- If you have had hepatitis B before or carry the virus, rituximab and hyaluronidase can cause the virus to become active. This can lead to very bad and sometimes deadly liver problems. You will be tested for hepatitis B before starting rituximab and hyaluronidase. You will need to watch for signs of hepatitis while taking rituximab and hyaluronidase and for several months after stopping it. Talk with your doctor.
- A very bad brain problem called progressive multifocal leukoencephalopathy (PML) has happened with rituximab and hyaluronidase. It may cause disability or can be deadly. Tell your doctor right away if you have signs like confusion, memory problems, low mood (depression), change in the way you act, change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or change in eyesight.
Uses of Rituximab and Hyaluronidase:
- It is used to treat types of leukemia and lymphoma.
What do I need to tell my doctor BEFORE I take Rituximab and Hyaluronidase?
- If you are allergic to rituximab and hyaluronidase; any part of rituximab and hyaluronidase; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you have an infection.
- If you have recently had a live vaccine
- If you are breast-feeding. Do not breast-feed while you take rituximab and hyaluronidase or within 6 months after your last dose.
This is not a list of all drugs or health problems that interact with rituximab and hyaluronidase.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take rituximab and hyaluronidase with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Rituximab and Hyaluronidase?
- Tell all of your health care providers that you take rituximab and hyaluronidase. This includes your doctors, nurses, pharmacists, and dentists.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- You may have more of a chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu. Some infections have been very bad and even deadly.
- Very bad and sometimes deadly allergic reactions have rarely happened with other forms of rituximab and hyaluronidase as well as drugs like this one. Talk with the doctor.
- Talk with your doctor before getting any vaccines. Use of some vaccines with rituximab and hyaluronidase may either raise the chance of an infection or make the vaccine not work as well.
- If you have upset stomach, throwing up, diarrhea, or are not hungry, talk with your doctor. There may be ways to lower these side effects.
- Skin reactions have happened where the shot is given or close to the area. This includes pain, swelling, hardness, redness, bleeding, itching, and rash. These skin reactions have also happened more than 24 hours after the injection. Talk with your doctor if you have a skin reaction near where the shot was given.
- People who took rituximab and hyaluronidase with some cancer drugs have had bowel block or tears in the bowel. Sometimes this has been deadly. Call your doctor right away if you have very bad stomach pain; very bad constipation; throwing up, throwing up blood, or throw up that looks like coffee grounds; or black, tarry, or bloody stools.
- Patients with cancer who take rituximab and hyaluronidase may be at a greater risk of getting a severe health problem called tumor lysis syndrome (TLS).This may lead to death. Call your doctor right away if you have a fast or abnormal heartbeat; any passing out; trouble passing urine; muscle weakness or cramps; upset stomach, throwing up, diarrhea, or not able to eat; or feel sluggish.
- A very bad and sometimes deadly health problem called cytokine release syndrome (CRS) has happened in people getting rituximab and hyaluronidase. Call your doctor right away if you have chills, dizziness, feeling tired or weak, fever, headache, passing out, rash, swelling of the face, trouble breathing, upset stomach or throwing up, or wheezing.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant.
- Women must use birth control while taking rituximab and hyaluronidase and for some time after the last dose. Ask your doctor how long to use birth control. If you get pregnant, call your doctor right away.
- If you used rituximab and hyaluronidase when you were pregnant, tell your baby's doctor.
How is this medicine (Rituximab and Hyaluronidase) best taken?
Use rituximab and hyaluronidase as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as an injection into the fatty part of the skin in the belly area. It will take 5 to 7 minutes to inject rituximab and hyaluronidase.
- Other drugs will be given with rituximab and hyaluronidase to help avoid side effects.
- You will be watched closely while you receive rituximab and hyaluronidase and for some time after your dose. Talk with your doctor.
- If you take other drugs as an injection into the fatty part of the skin, do not give into the same site where rituximab and hyaluronidase was given.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
- Chest pain or pressure.
- Any unexplained bruising or bleeding.
- A burning, numbness, or tingling feeling that is not normal.
- Heart problems like heart failure and certain very bad abnormal heartbeats have happened with rituximab and hyaluronidase. Sometimes, these heart problems have been deadly. Call your doctor right away if you have a fast or abnormal heartbeat; very bad dizziness or passing out; or shortness of breath, a big weight gain, or swelling in the arms or legs.
- Very bad and sometimes deadly kidney problems have happened with rituximab and hyaluronidase. Call your doctor right away if you are unable to pass urine or if you have blood in the urine or a change in the amount of urine passed.
- Some people have had lung problems with rituximab and hyaluronidase. Sometimes, this has been deadly. Call your doctor right away if you have signs of lung problems like shortness of breath or other trouble breathing, cough that is new or worse, or fever.
What are some other side effects of Rituximab and Hyaluronidase?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Constipation, diarrhea, stomach pain, upset stomach, throwing up, or feeling less hungry.
- Hair loss.
- Irritation where the shot is given.
- Feeling tired or weak.
- Signs of a common cold.
- Nose or throat irritation.
- Muscle spasm.
- Back, bone, joint, or muscle pain.
- Trouble sleeping.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Rituximab and Hyaluronidase?
- If you need to store rituximab and hyaluronidase at home, talk with your doctor, nurse, or pharmacist about how to store it.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time rituximab and hyaluronidase is refilled. If you have any questions about rituximab and hyaluronidase, please talk with the doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
More about hyaluronidase / rituximab
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- Drug class: CD20 monoclonal antibodies
- Other brands
- Rituxan Hycela
Related treatment guides
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