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Prochieve (Vaginal 8% Gel)

Generic Name: Progesterone Vaginal 8% Gel (pro JESS ter ohn)
Brand Name: Crinone, Prochieve

Medically reviewed on July 4, 2018

Uses of Prochieve:

  • It is used in in vitro fertilization.
  • It is used to treat females who do not have a monthly period cycle.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Prochieve?

  • If you have an allergy to progesterone or any other part of Prochieve (progesterone vaginal 8% gel).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have had any of these health problems: Bleeding disorder; blood clots or risk of having a blood clot; breast cancer; liver disease; recent heart attack; or recent stroke.
  • If you have had any of these health problems: Vaginal bleeding where the cause is not known or cancer of the uterus, ovary, cervix, or vagina.
  • If you have had a recent miscarriage.

This is not a list of all drugs or health problems that interact with Prochieve (progesterone vaginal 8% gel).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Prochieve (progesterone vaginal 8% gel) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Prochieve?

  • Tell all of your health care providers that you take Prochieve (progesterone vaginal 8% gel). This includes your doctors, nurses, pharmacists, and dentists.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how Prochieve (progesterone vaginal 8% gel) affects you.
  • If you have an allergy to any type of nuts or seeds, talk with your doctor.
  • If you have high blood sugar (diabetes), talk with your doctor. This medicine may raise blood sugar.
  • Be sure to have regular breast exams and gynecology check-ups. Your doctor will tell you how often to have these. You will also need to do breast self-exams as your doctor has told you. Talk with your doctor.
  • This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take Prochieve (progesterone vaginal 8% gel).
  • Blood clots have happened with Prochieve (progesterone vaginal 8% gel). These clots have included heart attack, stroke, and clots in the leg, lung, or eye. Sometimes blood clots can be deadly. Tell your doctor if you have ever had a blood clot. Talk with your doctor.
  • Talk with your doctor if you will need to be still for long periods of time like long trips, bedrest after surgery, or illness. Not moving for long periods may raise your chance of blood clots.
  • If you are 65 or older, use Prochieve (progesterone vaginal 8% gel) with care. You could have more side effects.
  • This medicine is not approved for use in children. Talk with the doctor.
  • This medicine may stop you from having a period (menstrual bleeding) for some time. This is not a method of birth control.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Prochieve (progesterone vaginal 8% gel) while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Prochieve) best taken?

Use Prochieve (progesterone vaginal 8% gel) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Follow how to use as you have been told by the doctor or read the package insert.
  • Do not take Prochieve (progesterone vaginal 8% gel) by mouth. For vaginal use only. Keep out of your mouth, nose, and eyes (may burn).
  • Wash hands before and after use.
  • Do not use the applicators more than 1 time.
  • Do not take other vaginal drugs within 6 hours of Prochieve (progesterone vaginal 8% gel).

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Chest pain or pressure.
  • Shortness of breath.
  • Coughing up blood.
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
  • Swelling, warmth, numbness, change of color, or pain in a leg or arm.
  • Shortness of breath, a big weight gain, or swelling in the arms or legs.
  • Trouble walking.
  • Very bad headache.
  • Very upset stomach or throwing up.
  • Very bad dizziness or passing out.
  • Bulging eyes.
  • Change in eyesight.
  • Loss of eyesight.
  • A lump in the breast, breast soreness, or nipple discharge.
  • Breast pain.
  • Vaginal itching or discharge.
  • Vaginal bleeding that is not normal.
  • Pain when passing urine.
  • Passing urine more often.
  • Low mood (depression).
  • Mood changes.
  • Memory problems or loss.
  • Seizures.
  • Flushing.
  • A fast heartbeat.
  • A heartbeat that does not feel normal.

What are some other side effects of Prochieve?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Dizziness.
  • Feeling sleepy.
  • Not able to sleep.
  • More hungry.
  • Hard stools (constipation).
  • Headache.
  • Pimples (acne).
  • Hair loss.
  • Hair growth.
  • Upset stomach or throwing up.
  • Belly pain.
  • Cramps.
  • Bloating.
  • Loose stools (diarrhea).
  • Enlarged breasts.
  • Tender breasts.
  • Muscle pain.
  • Back pain.
  • Feeling tired or weak.
  • Weight gain or loss.
  • Vaginal bleeding or spotting.
  • Lowered interest in sex.
  • Vaginal irritation.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Prochieve?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Prochieve (progesterone vaginal 8% gel), please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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