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Pro-Clear AC syrup

Generic Name: codeine/pyrilamine (KOE-deen/pir-IL-a-meen)
Brand Name: Pro-Clear AC

Some children have had serious and sometimes fatal breathing problems when using codeine after surgery to remove tonsils or adenoids. Talk with your doctor for more information.


Pro-Clear AC syrup is used for:

Relieving runny nose, sneezing, and cough due to colds, upper respiratory infections, and allergies. It may also be used for other conditions as determined by your doctor.

Pro-Clear AC syrup is an antihistamine and narcotic cough suppressant combination. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing. The cough suppressant works in the brain to help decrease the cough reflex, which reduces dry cough.

Do NOT use Pro-Clear AC syrup if:

  • you are allergic to any ingredient in Pro-Clear AC syrup or any other codeine- or morphine-related medicine
  • you have severe high blood pressure, severe heart blood vessel disease, increased pressure in the brain, respiratory depression, angle-closure glaucoma, or peptic ulcers
  • you are unable to urinate or are having an asthma attack
  • you are taking sodium oxybate (GHB) or if you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days
  • the patient is a child and has just had surgery to remove tonsils or adenoids

Contact your doctor or health care provider right away if any of these apply to you.

Before using Pro-Clear AC syrup:

Some medical conditions may interact with Pro-Clear AC syrup. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have heart blood vessel problems, irregular heartbeat, or any other heart problems (eg, cor pulmonale)
  • if you have a history of high blood pressure; diabetes; liver problems; stroke; glaucoma or increased pressure in the eye; a blockage of your bladder, stomach, or bowels; ulcers; trouble urinating; an enlarged prostate or other prostate problems; or an overactive thyroid
  • if you have a history of asthma, chronic cough, lung or breathing problems (eg, chronic bronchitis, emphysema, sleep apnea, slow or irregular breathing), or chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus
  • if you have severe drowsiness, recent head or brain injury, brain tumor or lesions, infection of the brain or nervous system, or a seizure disorder (eg, epilepsy)
  • if you have a history of constipation, stomach problems (eg, ulcers), bowel problems (eg, chronic inflammation or ulceration of the bowel), urinary problems (eg, urinary tract obstruction), or gallbladder problems (eg, gallstones), or if you have had recent stomach or bowel surgery
  • if you have a history of alcohol or substance abuse or suicidal thoughts or behavior, or if you are very overweight

Some MEDICINES MAY INTERACT with Pro-Clear AC syrup. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticholinergics (eg, scopolamine) because a serious bowel motility problem (paralytic ileus) may occur
  • Cimetidine, furazolidone, GHB , HIV protease inhibitors (eg, ritonavir), MAOIs (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Pro-Clear AC syrup's side effects
  • Narcotic pain medicines (eg, hydrocodone) because the risk of their side effects may be increased by Pro-Clear AC syrup
  • Naltrexone, quinidine, or rifamycins (eg, rifampin) because they may decrease Pro-Clear AC syrup's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Pro-Clear AC syrup may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Pro-Clear AC syrup:

Use Pro-Clear AC syrup as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Pro-Clear AC syrup by mouth with or without food.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • If you miss a dose of Pro-Clear AC syrup, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Pro-Clear AC syrup.

Important safety information:

  • Pro-Clear AC syrup may cause dizziness, drowsiness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Pro-Clear AC syrup with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Pro-Clear AC syrup; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Do not take diet or appetite control medicines while you are taking Pro-Clear AC syrup without checking with your doctor.
  • Pro-Clear AC syrup has codeine and pyrilamine in it. Before you start any new medicine, check the label to see if it has codeine or pyrilamine in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • If your cough or other symptoms persist for more than 1 week, come back, or if you also have fever, rash, or persistent headache, check with your doctor.
  • Pro-Clear AC syrup may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking Pro-Clear AC syrup for a few days before the test.
  • Tell your doctor or dentist that you take Pro-Clear AC syrup before you receive any medical or dental care, emergency care, or surgery.
  • Use Pro-Clear AC syrup with caution in the ELDERLY; they may be more sensitive to its effects.
  • Pro-Clear AC syrup should not be used in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Pro-Clear AC syrup while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking Pro-Clear AC syrup.

When used for long periods of time or at high doses, Pro-Clear AC syrup may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Pro-Clear AC syrup stops working well. Do not take more than prescribed.

When used for long periods of time or at high doses, some people develop a need to continue taking Pro-Clear AC syrup. This is known as DEPENDENCE or addiction.

If you suddenly stop taking Pro-Clear AC syrup, you may experience WITHDRAWAL symptoms including anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; pain; rigid muscles; rapid heartbeat; seeing, hearing or feeling things that are not there; shivering or tremors; sweating; trouble sleeping; vomiting.

Possible side effects of Pro-Clear AC syrup:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; headache; loss of appetite; nausea; thickening of mucus secretions; upset stomach; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision, double vision, or other vision changes; confusion; difficulty urinating or inability to urinate; fast or irregular heartbeat; loss of coordination; mood or mental changes; nervousness; ringing in the ears; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; tremor; trouble sleeping; unusual bruising or bleeding; unusual weakness or tiredness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; cold, clammy skin; coma; confusion; hallucinations; muscle weakness; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Pro-Clear AC syrup:

Store Pro-Clear AC syrup at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Pro-Clear AC syrup out of the reach of children and away from pets.

General information:

  • If you have any questions about Pro-Clear AC syrup, please talk with your doctor, pharmacist, or other health care provider.
  • Pro-Clear AC syrup is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Pro-Clear AC syrup or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Pro-Clear AC syrup. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Pro-Clear AC syrup. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Pro-Clear AC syrup.

Review Date: November 3, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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