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Prevacid NapraPAC

Generic Name: lansoprazole and naproxen (lan-SOE-pra-zole and na-PROX-en)
Brand Name: Prevacid NapraPAC

Prevacid NapraPAC contains a nonsteroidal anti-inflammatory drug (NSAID). It may cause an increased risk of serious and sometimes fatal heart and blood vessel problems (eg, heart attack, stroke). The risk may be greater if you already have heart problems or if you take Prevacid NapraPAC for a long time. Do not use Prevacid NapraPAC right before or after bypass heart surgery.

Prevacid NapraPAC may cause an increased risk of serious and sometimes fatal stomach ulcers and bleeding. Elderly patients may be at greater risk. This may occur without warning signs.

Prevacid NapraPAC is used for:

Treating rheumatoid arthritis, osteoarthritis, or ankylosing spondylitis in certain patients with a history of gastric ulcer. It may also be used for other conditions as determined by your doctor.

Prevacid NapraPAC is a combination package that contains an NSAID and a proton pump inhibitor (PPI). Exactly how the NSAID works is not known. It may block certain substances in the body that are linked to inflammation. NSAIDs treat symptoms of pain and inflammation. The PPI works by decreasing the amount of acid produced in the stomach. This decreases the risk of developing an ulcer from using an NSAID.

Do NOT use Prevacid NapraPAC if:

  • you are allergic to any ingredient in Prevacid NapraPAC
  • you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)
  • you have recently had or will be having bypass heart surgery
  • you have moderate to severe kidney problems
  • you are in the last 3 months of pregnancy
  • you are taking an HIV protease inhibitor (eg, atazanavir)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Prevacid NapraPAC:

Some medical conditions may interact with Prevacid NapraPAC. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of kidney or liver disease, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers, cancer)
  • if you have a history of swelling or fluid buildup, asthma, growths in the nose (nasal polyps), or mouth inflammation
  • if you have high blood pressure, blood disorders, bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases
  • if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you smoke or drink alcohol, or you have a history of alcohol abuse

Some MEDICINES MAY INTERACT with Prevacid NapraPAC. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin), aspirin, clopidogrel, corticosteroids (eg, prednisone), heparin, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased
  • Clarithromycin, probenecid, or voriconazole because they may increase the risk of Prevacid NapraPAC's side effects
  • Cyclosporine, digoxin, hydantoins (eg, phenytoin), lithium, methotrexate, quinolones (eg, ciprofloxacin), sulfonamides (eg, sulfamethoxazole), or sulfonylureas (eg, glipizide) because the risk of their side effects may be increased by Prevacid NapraPAC
  • Ampicillin, angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), azole antifungals (eg, ketaconazole) beta-blockers (eg, propranolol), clopidogrel, diuretics (eg, furosemide, hydrochlorothiazide), HIV protease inhibitors (eg, atazanavir), iron, or theophylline because their effectiveness may be decreased by Prevacid NapraPAC

This may not be a complete list of all interactions that may occur. Ask your health care provider if Prevacid NapraPAC may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Prevacid NapraPAC:

Use Prevacid NapraPAC as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Prevacid NapraPAC comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Prevacid NapraPAC refilled.
  • Take Prevacid NapraPAC by mouth before eating, unless your doctor tells you otherwise. Naproxen may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.
  • Take Prevacid NapraPAC with a full glass of water (8 oz/240 mL).
  • Swallow the lansoprazole capsule whole. Do not break, crush, or chew before swallowing.
  • If you are taking sucralfate, take Prevacid NapraPAC at least 30 minutes before taking sucralfate.
  • If you also take an imidazole antifungal (eg ketoconazole), take it at least 2 hours before taking Prevacid NapraPAC.
  • If you also take antacids or cholestyramine, ask your doctor or pharmacist how to take them with Prevacid NapraPAC.
  • Continue to take Prevacid NapraPAC even if you feel well. Do not miss any doses.
  • If you miss a dose of Prevacid NapraPAC, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Prevacid NapraPAC.

Important safety information:

  • Prevacid NapraPAC may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Prevacid NapraPAC with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Serious stomach ulcers or bleeding can occur with the use of an NSAID. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Prevacid NapraPAC with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Prevacid NapraPAC has naproxen in it. Before you start any new medicine, check the label to see if it has naproxen or any other NSAID (eg, ibuprofen) in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • Do not take aspirin while you are using Prevacid NapraPAC unless your doctor tells you to.
  • Prevacid NapraPAC may interfere with certain lab tests. Be sure your doctor and lab personnel know that you take Prevacid NapraPAC.
  • Lab tests, including kidney or liver function, complete blood cell counts, and blood pressure, may be performed while you use Prevacid NapraPAC. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Prevacid NapraPAC should be used with caution in Asian patients; the risk of side effects may be increased in these patients.
  • Use Prevacid NapraPAC with caution in the ELDERLY; they may be more sensitive to its effects, especially stomach bleeding and kidney problems.
  • Prevacid NapraPAC should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Prevacid NapraPAC may harm the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Prevacid NapraPAC while you are pregnant. Prevacid NapraPAC should not be used during labor. Prevacid NapraPAC is found in breast milk. Do not breast-feed while taking Prevacid NapraPAC.

Possible side effects of Prevacid NapraPAC:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; gas; headache; heartburn; nausea; stomach upset.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision, hearing, or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include decreased urination; loss of consciousness; seizures; severe dizziness or drowsiness; severe nausea or stomach pain; slow or troubled breathing; unusual bleeding or bruising; vomit that looks like coffee grounds.

Proper storage of Prevacid NapraPAC:

Store Prevacid NapraPAC at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store in the original packaging until just before use. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Prevacid NapraPAC out of the reach of children and away from pets.

General information:

  • If you have any questions about Prevacid NapraPAC, please talk with your doctor, pharmacist, or other health care provider.
  • Prevacid NapraPAC is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is summary only. It does not contain all information about Prevacid NapraPAC. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Review Date: April 11, 2017

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.