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Phenylephrine/ methscopolamine

Generic Name: phenylephrine/methscopolamine (FEN-il-EF-rin/METH-skoe-POL-a-meen with FEN-il-EF-rin/KLOR-fen-IR-a-meen/METH-skoe-POL-a-meen)
Brand Name: Examples include AlleRx PE and AlleRx PE 30

Phenylephrine/ methscopolamine is used for:

Relieving congestion, sneezing, runny nose, and itchy, watery eyes due to allergies, colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Phenylephrine/methscopolamine is a combination pack containing a morning dose and an evening dose. The morning dose has a decongestant and an anticholinergic medicine. The evening dose has an antihistamine and an anticholinergic medicine. The decongestant relieves nasal congestion by shrinking the nasal mucous membranes, which promotes nasal drainage. The antihistamine works by blocking histamine, a substance in the body that causes sneezing, runny nose, and watery eyes. The anticholinergic dries the chest by decreasing lung secretions.

Do NOT use phenylephrine/ methscopolamine if:

  • you are allergic to any ingredient in phenylephrine/methscopolamine
  • you are breast-feeding
  • you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, severe heart problems, or narrow-angle glaucoma
  • you are unable to urinate or are having an asthma attack
  • you are taking droxidopa, sodium oxybate (GHB), or you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using phenylephrine/ methscopolamine:

Some medical conditions may interact with phenylephrine/methscopolamine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of adrenal gland problems (eg, adrenal gland tumor), a hiatal hernia, heart problems (eg, fast, slow, or irregular heartbeat; heart disease), high blood pressure, low blood volume, diabetes, blood vessel problems, muscle weakness (eg, myasthenia gravis), seizures, stroke, glaucoma or increased pressure in the eye, or thyroid problems
  • if you have a history of asthma, chronic cough, lung or breathing problems (eg, chronic bronchitis, emphysema, sleep apnea), or chronic obstructive pulmonary disease (COPD)
  • if you have a history of stomach or bowel ulcers; constipation; a blockage of your stomach, bladder, or bowel; severe bowel problems (eg, ulcerative colitis, toxic megacolon); liver or kidney problems; or trouble urinating; or if you have an enlarged prostate or other prostate problems
  • if you will be exposed to high temperatures for a long period of time
  • if you take potassium chloride tablets or capsules

Some MEDICINES MAY INTERACT with phenylephrine/methscopolamine. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased
  • Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, linezolid, or MAOIs (eg, phenelzine) because the risk of high or low blood pressure may be increased
  • Anticholinergics (eg, benztropine), carbonic anhydrase inhibitors (eg, acetazolamide), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of phenylephrine/methscopolamine's side effects
  • Bromocriptine, hydantoins (eg, phenytoin), potassium chloride, or sodium oxybate (GHB) because the risk of their side effects may be increased by phenylephrine/methscopolamine
  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by phenylephrine/methscopolamine

This may not be a complete list of all interactions that may occur. Ask your health care provider if phenylephrine/methscopolamine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use phenylephrine/ methscopolamine:

Use phenylephrine/methscopolamine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take phenylephrine/methscopolamine by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • This product contains 2 different tablets: one for the morning and one for the evening. Be sure you understand how to take phenylephrine/methscopolamine. Check with your doctor or pharmacist if you are not sure which tablet to take in the morning or in the evening.
  • Do not take an antacid or certain medicines for diarrhea 2 to 3 hours before or after you take phenylephrine/methscopolamine.
  • If you miss a dose of phenylephrine/methscopolamine and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use phenylephrine/methscopolamine.

Important safety information:

  • Phenylephrine/methscopolamine may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use phenylephrine/methscopolamine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using phenylephrine/methscopolamine; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • If your symptoms do not get better within 7 days or if they get worse or you develop a high fever or persistent headache, check with your doctor.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Phenylephrine/methscopolamine may cause dry mouth. To relieve dry mouth, suck on sugarless hard candy or ice chips, chew sugarless gum, drink water, or use a saliva substitute.
  • Phenylephrine/methscopolamine may make your eyes more sensitive to sunlight. It may help to wear sunglasses.
  • Phenylephrine/methscopolamine may reduce sweating. Do not become overheated in hot weather or while you are being active; heatstroke may occur.
  • Do not take diet or appetite control medicines while you are taking phenylephrine/methscopolamine without checking with your doctor.
  • Before you start any new medicine, check the label to see if it has a decongestant, antihistamine, or anticholinergic in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • If you have trouble sleeping, ask your doctor or pharmacist about the best time of the day to take phenylephrine/methscopolamine.
  • Phenylephrine/methscopolamine may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking phenylephrine/methscopolamine.
  • Phenylephrine/methscopolamine may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking phenylephrine/methscopolamine for a few days before the tests.
  • Tell your doctor or dentist that you take phenylephrine/methscopolamine before you receive any medical or dental care, emergency care, or surgery.
  • Use phenylephrine/methscopolamine with caution in the ELDERLY; they may be more sensitive to its effects, especially confusion, dizziness, drowsiness, dry mouth, excitability, low blood pressure, and trouble urinating.
  • Caution is advised when using phenylephrine/methscopolamine in CHILDREN; they may be more sensitive to its effects, especially excitability.
  • Phenylephrine/methscopolamine should not be used in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using phenylephrine/methscopolamine while you are pregnant. Phenylephrine/methscopolamine is found in breast milk. Do not breast-feeding while taking phenylephrine/methscopolamine.

Possible side effects of phenylephrine/ methscopolamine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; dry mouth, nose, or throat; excitability; headache; increased sweating; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; confusion; difficulty swallowing; difficulty urinating or inability to urinate; fast or irregular heartbeat; fever, chills, or persistent sore throat; hallucinations; mental or mood changes; seizures; severe dizziness, drowsiness, lightheadedness, or headache; shortness of breath; tremor; unusual tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include deep sleep or sleep loss of consciousness; fast or irregular heartbeat; hot or cool skin; large pupils; numbness or tingling in the arms or legs; seizures; severe irritability, anxiety, or panicked feeling; slowed or shallow breathing; vomiting.

Proper storage of phenylephrine/methscopolamine:

Store phenylephrine/methscopolamine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep phenylephrine/methscopolamine out of the reach of children and away from pets.

General information:

  • If you have any questions about phenylephrine/methscopolamine, please talk with your doctor, pharmacist, or other health care provider.
  • Phenylephrine/methscopolamine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take phenylephrine/methscopolamine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about phenylephrine/methscopolamine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to phenylephrine/methscopolamine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using phenylephrine/methscopolamine.

Issue Date: June 3, 2015

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.