Generic Name: pertuzumab (per-TOOZ-ue-mab)
Brand Name: Perjeta
Pertuzumab may cause serious harm to the fetus if used during pregnancy. If you are able to become pregnant, you must use an effective form of birth control while you use pertuzumab and for 6 months after you stop using it. If you have questions about effective birth control, talk with your doctor. If you think you may be pregnant, contact your doctor right away.
Pertuzumab is used for:
Treating certain types of breast cancer that have spread to other areas of the body. Pertuzumab is used in combination with other medicines. It may also be used for other conditions as determined by your doctor.
Pertuzumab is a monoclonal antibody. It works by targeting certain tumor cells and stopping them from growing and reproducing.
Do NOT use pertuzumab if:
- you are allergic to any ingredient in pertuzumab
Contact your doctor or health care provider right away if any of these apply to you.
Before using pertuzumab:
Some medical conditions may interact with pertuzumab. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are able to become pregnant
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have had a reaction (eg, rash; hives; itching; difficulty breathing; shortness of breath; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; wheezing) to a previous dose of pertuzumab
- if you have a history of breathing or lung problems, heart problems (eg, heart failure, recent heart attack, irregular heartbeat), high blood pressure, kidney problems, chronic infections, or low white blood cell counts
- if you have had previous treatment with a certain type of chemotherapy called an anthracycline (eg, doxorubicin) or you have received radiation treatment
Some MEDICINES MAY INTERACT with pertuzumab. However, no specific interactions with pertuzumab are known at this time.
Ask your health care provider if pertuzumab may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use pertuzumab:
Use pertuzumab as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Pertuzumab is given as an injection at your doctor's office, hospital, or clinic.
- Do not use pertuzumab if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of pertuzumab, contact your doctor right away.
Ask your health care provider any questions you may have about how to use pertuzumab.
Important safety information:
- Pertuzumab may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use pertuzumab with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Pertuzumab may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
- Some patients may experience an infusion reaction with pertuzumab. Symptoms may include chills, fever, headache, muscle pain, nausea, taste changes, tiredness, vomiting, or weakness. Tell your doctor if you notice these or other unusual effects while you use pertuzumab.
- A more severe infusion reaction may sometimes occur with pertuzumab. Tell your doctor right away if you notice fainting; new or worsening shortness of breath; trouble breathing; rash; swelling of the mouth, face, lips, tongue, or throat; severe dizziness or light-headedness; unusual hoarseness; or wheezing.
- Tell your doctor or dentist that you take pertuzumab before you receive any medical or dental care, emergency care, or surgery.
- Do not receive a live vaccine (eg, measles, mumps) while you are taking pertuzumab. Talk with your doctor before you receive any vaccine.
- Women who may become pregnant should have a negative pregnancy test before they start to take pertuzumab. Discuss any questions or concerns with your doctor.
- If you are able to become pregnant, you must use an effective form of birth control while you use pertuzumab and for 6 months after you stop using it. If you have questions about effective birth control, talk with your doctor.
- Lab tests, including heart function and HER2 protein testing, may be performed while you use pertuzumab. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use pertuzumab with caution in Asian patients; they may be at an increased risk for decreased ability to fight infection.
- Pertuzumab should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: Pertuzumab may cause harm to the fetus. Do not become pregnant while you are using it and for 6 months after you stop using it. If you think you may be pregnant, contact your doctor right away. It is not known if this medicine is found in breast milk. Do not breast-feed while using pertuzumab.
Possible side effects of pertuzumab:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Change in taste; diarrhea; dizziness; dry skin; fingernail or toenail changes; hair loss; headache; loss of appetite; mild muscle or joint pain; nausea; nose, sinus, or throat irritation; runny or stuffy nose; tiredness; trouble sleeping; vomiting; weakness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue); burning, numbness, or tingling; fainting; new or worsening shortness of breath or trouble breathing; pain, redness, or swelling at the injection site; pain, swelling, or sores of the mouth or tongue; severe or persistent dizziness or light-headedness; skin or nail infection (eg, skin discharge, redness, swelling, or warmth); sudden, unexplained weight gain; swelling of the hands, ankles, or feet; symptoms of infection (eg, fever, chills, persistent sore throat); unusual tiredness or weakness; wheezing.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of pertuzumab:
Pertuzumab is handled and stored by a health care provider. Keep pertuzumab out of the reach of children and away from pets.
- If you have any questions about pertuzumab, please talk with your doctor, pharmacist, or other health care provider.
- Pertuzumab is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take pertuzumab or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about pertuzumab. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to pertuzumab. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using pertuzumab.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about pertuzumab
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Español
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- Drug class: HER2 inhibitors
Other brands: Perjeta