The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content.
Generic Name: doxycycline (DOX-i-SYE-kleen)
Brand Name: Periostat
Periostat is used for:
Treating periodontitis, a dental disease that attacks the gum, bone, and around the teeth.
Periostat is a tetracycline. It works to treat periodontitis by decreasing the activity of a certain enzyme (collagenase).
Do NOT use Periostat if:
- you are allergic to any ingredient in Periostat or to another tetracycline (eg, minocycline)
- you are taking acitretin, isotretinoin, methotrexate, or a blood thinner (eg, warfarin)
- you have recently received or will be receiving a live oral typhoid vaccine
Contact your doctor or health care provider right away if any of these apply to you.
Before using Periostat:
Some medical conditions may interact with Periostat. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have diarrhea, a stomach infection, a history of lupus, or the blood disease porphyria
- if you have a history of oral yeast infections
Some MEDICINES MAY INTERACT with Periostat. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Barbiturates (eg, phenobarbital), carbamazepine, cimetidine, colestipol, hydantoins (eg, phenytoin), or rifampin because they may decrease Periostat's effectiveness
- Acitretin, digoxin, insulin,isotretinoin, methotrexate, methoxyflurane,blood thinners (eg, warfarin), or theophylline because the risk of their side effects may be increased by Periostat
- Live oral typhoid vaccine, hormonal birth control (eg, birth control pills), or penicillins (eg, amoxicillin) because their effectiveness may be decreased by Periostat
This may not be a complete list of all interactions that may occur. Ask your health care provider if Periostat may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Periostat:
Use Periostat as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Periostat by mouth on an empty stomach at least 1 hour before or 2 hours after eating.
- Do not take an antacid that has aluminum, calcium, or magnesium in it; bismuth subsalicylate; iron; zinc; or multivitamins with minerals within 2 hours before or 2 hours after you take Periostat.
- Do not eat or drink dairy products within 1 hour before or 2 hours after you take Periostat.
- To clear up your infection completely, take Periostat for the full course of treatment. Keep taking it even if you feel better in a few days.
- Drink plenty of nondairy fluid with Periostat to wash it down and avoid the risk of sore throat.
- Take Periostat twice daily (every 12 hours), preferably in the morning and evening.
- Continue to take Periostat even if you feel well. Do not miss any doses.
- If you miss a dose of Periostat, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Periostat.
Important safety information:
- Hormonal birth control (eg, birth control pills) may not work as well while you are using Periostat. To prevent pregnancy, use an extra form of birth control (eg, condoms).
- Mild diarrhea is common with this type of medicine. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use Periostat or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
- Long-term or repeated use of Periostat may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
- Periostat may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Periostat. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
- Tell your doctor or dentist that you take Periostat before you receive any medical or dental care, emergency care, or surgery.
- Periostat may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Periostat.
- Lab tests, including liver function, kidney function, and complete blood counts, may be performed while you use Periostat. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Periostat should not be used in CHILDREN younger than 8 years old; permanent yellow-gray-brown tooth discoloration may occur.
- PREGNANCY and BREAST-FEEDING: Periostat has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Periostat while you are pregnant. Periostat is found in breast milk. Do not breast-feed while taking Periostat.
Possible side effects of Periostat:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Diarrhea; nausea; sensitivity to sunlight; stomach upset.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody stools; chest pain; dark urine; decreased urination; fever, chills, or sore throat; moderate to severe sunburn; red, swollen, blistered, or peeling skin; severe diarrhea; severe or persistent headache; stomach pain or cramps; throat irritation; trouble swallowing; unusual bruising or bleeding; unusual joint pain; unusual tiredness; vaginal irritation or discharge; vision changes; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Periostat:
Store Periostat at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Periostat out of the reach of children and away from pets.
- If you have any questions about Periostat, please talk with your doctor, pharmacist, or other health care provider.
- Periostat is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Periostat or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Periostat. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Periostat. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Periostat.