Generic Name: Pemetrexed (pem e TREKS ed)
Brand Name: Alimta
Medically reviewed on July 4, 2018
Uses of Pemetrexed:
- It is used to treat lung cancer.
- It is used to treat mesothelioma.
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Pemetrexed?
- If you have an allergy to pemetrexed or any other part of pemetrexed.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have any of these health problems: Bone marrow disease (like low white blood cell count, low platelet count, or anemia).
- If you have kidney problems.
- If you are breast-feeding. Do not breast-feed while you take pemetrexed and for 1 week after your last dose.
This is not a list of all drugs or health problems that interact with pemetrexed.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take pemetrexed with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Pemetrexed?
- Tell all of your health care providers that you take pemetrexed. This includes your doctors, nurses, pharmacists, and dentists.
- You may have more of a chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu. Some infections have been very bad and even deadly.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- If you have upset stomach, throwing up, loose stools (diarrhea), or are not hungry, talk with your doctor. There may be ways to lower these side effects.
- If loose stools (diarrhea) or throwing up happens, you will need to make sure to avoid dehydration and electrolyte problems. Talk with the doctor.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- If you have ever had radiation, talk with your doctor.
- Other drugs will be given with pemetrexed to help avoid side effects. Follow how to take these other drugs as your doctor has told you.
- If you are 65 or older, use pemetrexed with care. You could have more side effects.
- This medicine may affect being able to father a child. It is not known how long this effect lasts. Talk with the doctor.
- If you are a man and have sex with a female who could get pregnant, protect her from pregnancy during care and for 3 months after care ends. Use birth control that you can trust.
- If you are a man and your sex partner gets pregnant while you take pemetrexed or within 3 months after your last dose, call your doctor right away.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant.
- Use birth control that you can trust to prevent pregnancy while taking pemetrexed and for 6 months after stopping pemetrexed.
- If you get pregnant while taking pemetrexed or within 6 months after your last dose, call your doctor right away.
How is this medicine (Pemetrexed) best taken?
Use pemetrexed as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as an infusion into a vein over a period of time.
- Take folic acid 1 week before, during, and for 3 weeks after your care.
- You will need to have vitamin B12 shots before your first dose and while you are using pemetrexed. Talk with your doctor.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
See also: Dosage Information (in more detail)
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
- Signs of dehydration like dry skin, mouth, or eyes; thirst; fast heartbeat; dizziness; fast breathing; or confusion.
- Feeling very tired or weak.
- Very bad mouth pain or irritation.
- A burning, numbness, or tingling feeling that is not normal.
- Pale skin.
- Very bad and sometimes deadly kidney problems have happened with pemetrexed. Call your doctor right away if you are unable to pass urine or if you have blood in the urine or a change in the amount of urine passed.
- A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
- Very bad and sometimes deadly lung problems have happened with pemetrexed. Call your doctor right away if you have lung or breathing problems like trouble breathing, shortness of breath, or a cough that is new or worse.
What are some other side effects of Pemetrexed?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling tired or weak.
- Upset stomach or throwing up.
- Loose stools (diarrhea).
- Hard stools (constipation).
- Not hungry.
- Mouth irritation or mouth sores.
- Change in taste.
- Hair loss.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Pemetrexed?
- If you need to store pemetrexed at home, talk with your doctor, nurse, or pharmacist about how to store it.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about pemetrexed, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about pemetrexed
- Pemetrexed Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- 2 Reviews
- Drug class: antimetabolites
Other brands: Alimta