Skip to Content

Pasireotide Extended-Release Injection

Generic Name: Pasireotide Extended-Release Injection (pas i REE oh tide)
Brand Name: Signifor

Medically reviewed on July 4, 2018

Uses of Pasireotide Extended-Release Injection:

What do I need to tell my doctor BEFORE I take Pasireotide Extended-Release Injection?

  • If you have an allergy to pasireotide or any other part of pasireotide extended-release injection.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Low potassium or magnesium levels.
  • If you have high blood sugar (diabetes).
  • If you have liver disease.

This is not a list of all drugs or health problems that interact with pasireotide extended-release injection.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take pasireotide extended-release injection with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Pasireotide Extended-Release Injection?

  • Tell all of your health care providers that you take pasireotide extended-release injection. This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • You will need an ECG before starting pasireotide extended-release injection. You may also need to have an ECG while using pasireotide extended-release injection. Talk with your doctor.
  • High blood sugar has happened with pasireotide extended-release injection. This includes diabetes that is new or worse. Talk with the doctor.
  • Check your blood sugar as you have been told by your doctor.
  • Tell your doctor if you have signs of high or low blood sugar like breath that smells like fruit, dizziness, fast breathing, fast heartbeat, feeling confused, feeling sleepy, feeling weak, flushing, headache, more thirsty or hungry, passing urine more often, shaking, or sweating.
  • If you are taking cyclosporine, talk with your doctor. You may need to have your blood work checked more closely while you are taking it with pasireotide extended-release injection.
  • If you have not been through menopause and are able to get pregnant, talk with your doctor. The use of pasireotide extended-release injection may lead to being more fertile or unplanned pregnancy.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using pasireotide extended-release injection while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Pasireotide Extended-Release Injection) best taken?

Use pasireotide extended-release injection as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as a shot into a muscle.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of gallstones like sudden pain in the upper right belly area, right shoulder area, or between the shoulder blades; yellow skin or eyes; or fever with chills.
  • Signs of low sodium levels like headache, trouble focusing, memory problems, feeling confused, weakness, seizures, or change in balance.
  • Signs of high or low blood pressure like very bad headache or dizziness, passing out, change in eyesight.
  • Signs of low potassium levels like muscle pain or weakness, muscle cramps, or a heartbeat that does not feel normal.
  • Slow heartbeat.
  • Yellow skin or eyes.
  • Swelling of belly.
  • This medicine may lower the amount of certain hormones in your body. Call your doctor right away if you have abnormal diarrhea, dizziness, feeling tired or weak, nausea, not hungry, passing out, throwing up, or weight loss.
  • A type of abnormal heartbeat (prolonged QT interval) can happen with pasireotide extended-release injection. Call your doctor right away if you have a fast heartbeat, a heartbeat that does not feel normal, or if you pass out.

What are some other side effects of Pasireotide Extended-Release Injection?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Belly pain.
  • Headache.
  • Feeling tired or weak.
  • Upset stomach or throwing up.
  • Loose stools (diarrhea).
  • Hair loss.
  • Nose and throat irritation.
  • Dizziness.
  • Irritation where the shot is given.
  • Joint pain.
  • Flu-like signs.
  • Back pain.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Pasireotide Extended-Release Injection?

  • If you need to store pasireotide extended-release injection at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about pasireotide extended-release injection, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Hide