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Here’s what to ask a doctor about hereditary angioedema

Papain/ urea ointment

Generic Name: papain/urea (pap-ANE/you-REE-ah)
Brand Name: Examples include Accuzyme and Ethezyme

Papain/ urea ointment is used for:

Removing dead tissue and thinning the pus in lesions such as ulcers, burns, wounds, and carbuncles.

Papain/urea ointment is a debriding agent. It works by helping the breakdown of dead skin and pus, which helps improve the recovery time of open wounds.

Do NOT use papain/ urea ointment if:

  • you are allergic to any ingredient in papain/urea ointment

Contact your doctor or health care provider right away if any of these apply to you.

Before using papain/ urea ointment:

Some medical conditions may interact with papain/urea ointment. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with papain/urea ointment. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Medicines containing silver, lead, or mercury because they may decrease papain/urea ointment's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if papain/urea ointment may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use papain/ urea ointment:

Use papain/urea ointment as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Papain/urea ointment is for external use only.
  • Before each use of papain/urea ointment, clean the affected area with saline or another mild wound cleansing solution. Do not use hydrogen peroxide.
  • Apply papain/urea ointment directly to the lesion, cover with appropriate dressing (eg, bandages), and secure into place. Wash the lesion each time the dressing is changed.
  • Change wound dressings according to the schedule set by your doctor.
  • If irritation occurs, talk with your doctor about changing the dressings more often.
  • If you miss a dose of papain/urea ointment, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use papain/urea ointment.

Important safety information:

  • Papain/urea ointment is for external use only. Do not get it in the eyes or mouth. If you get papain/urea ointment in the eyes, rinse them immediately with a generous amount of cool water.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using papain/urea ointment while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use papain/urea ointment, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of papain/ urea ointment:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild skin irritation; temporary burning sensation.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of papain/urea ointment:

Store papain/urea ointment in a cool place, between 46 and 59 degrees F (8 and 15 degrees C). Do not refrigerate. Store away from heat, moisture, and light. Do not store in the bathroom. Keep papain/urea ointment out of the reach of children and away from pets.

General information:

  • If you have any questions about papain/urea ointment, please talk with your doctor, pharmacist, or other health care provider.
  • Papain/urea ointment is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take papain/urea ointment or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about papain/urea ointment. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to papain/urea ointment. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using papain/urea ointment.

Review Date: November 3, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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