Generic Name: oxycodone/aspirin (OX-i-KOE-done/AS-pir-in)
Brand Name: Examples include Endodan and Percodan
Oxycodone/ aspirin is used for:
Treating moderate to moderately severe pain.
Oxycodone/aspirin is a narcotic pain reliever and salicylate combination. The narcotic works in the brain to reduce pain. The salicylate works by blocking certain chemicals in the body that cause pain and inflammation.
Do NOT use oxycodone/ aspirin if:
- you are allergic to any ingredient in oxycodone/aspirin or to a nonsteroidal anti-inflammatory drug (NSAID) (eg, ibuprofen, naproxen, celecoxib)
- you have had asthma symptoms (eg, shortness of breath, wheezing), nasal swelling, or growths in the nose caused by aspirin
- you have moderate to severe breathing problems, severe asthma, or you are having an asthma attack
- you have a history of certain bleeding problems (eg, hemophilia, von Willebrand disease), low blood platelet levels, stomach ulcers, or you have severe bleeding
- you have known or suspected bowel blockage (paralytic ileus) or you have severe or persistent diarrhea caused by antibiotics
- the patient is a child with a viral infection (eg, chickenpox, flu symptoms)
- you are taking sodium oxybate (GHB) or ketorolac
Contact your doctor or health care provider right away if any of these apply to you.
Before using oxycodone/ aspirin:
Some medical conditions may interact with oxycodone/aspirin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you are allergic to other narcotic pain relievers (eg, morphine, codeine, hydromorphone)
- if you have a history of constipation, lung or breathing problems (eg, asthma, emphysema, bronchitis, chronic obstructive pulmonary disease [COPD]), sleep apnea (you stop breathing when you sleep), curvature of the spine (eg, kyphoscoliosis), heart problems (eg, cor pulmonale), low blood pressure, dehydration, low blood volume, or shock caused by heart problems
- if you have a history of recent head injury, growths in the brain (eg, tumors, lesions), an enlarged blood vessel in the brain (eg, aneurysm), increased pressure in the brain, stroke, or seizures (eg, epilepsy)
- if you have blood problems (eg, porphyria), bleeding or clotting problems, low levels of vitamin K in the blood, chickenpox or flu symptoms, hives, Kawasaki syndrome, a rheumatic condition, or severe drowsiness
- if you have a history of kidney or liver problems, thyroid problems, stomach or bowel problems (eg, ulcers, inflammation, recent surgery), pancreas or gallbladder problems, adrenal problems (Addison disease), an enlarged prostate, blockage of your bladder, or trouble urinating
- if you have a history of mood or mental problems (eg, depression, hallucinations), suicidal thoughts or behavior, alcohol or other substance abuse, regular alcohol use, or if you are in alcohol withdrawal
- if you are in poor health or will be having surgery
Some MEDICINES MAY INTERACT with oxycodone/aspirin. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Anticoagulants (eg, heparin, warfarin, enoxaparin), clopidogrel, dabigatran, desirudin, NSAIDs (eg, ibuprofen, ketorolac), rivaroxaban, or selective serotonin reuptake inhibitors (SSRIs) (eg, citalopram) because the risk of bleeding or ulcers may be increased
- Certain antinausea medicines (eg, metoclopramide), azole antifungals (eg, ketoconazole), cimetidine, HIV protease inhibitors (eg, ritonavir), macrolide antibiotics (eg, clarithromycin), muscle relaxants (eg, cyclobenzaprine), narcotic pain relievers (eg, codeine), nefazodone, phenothiazines (eg, chlorpromazine), sodium oxybate (GHB), or telithromycin because the risk of serious side effects, such as severe drowsiness or slow or difficult breathing, may be increased
- Mixed narcotic agonists/antagonists (eg, buprenorphine, butorphanol, nalbuphine, pentazocine), naltrexone, or rifamycins (eg, rifampin) because they may decrease oxycodone/aspirin's effectiveness
- Carbonic anhydrase inhibitors (eg, acetazolamide), insulin, methotrexate, oral diabetes medicines (eg, glyburide, repaglinide), phenytoin, or valproic acid because the risk of their side effects may be increased by oxycodone/aspirin
- Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), beta-blockers (eg, propranolol), diuretics (eg, furosemide, hydrochlorothiazide), probenecid, or sulfinpyrazone because their effectiveness may be decreased by oxycodone/aspirin
This may not be a complete list of all interactions that may occur. Ask your health care provider if oxycodone/aspirin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use oxycodone/ aspirin:
Use oxycodone/aspirin as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take oxycodone/aspirin by mouth with or without food. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.
- Do not change your dose or suddenly stop taking oxycodone/aspirin without first checking with your doctor.
- If oxycodone/aspirin is no longer needed, dispose of it as soon as possible. Ask your doctor or pharmacist how to dispose of oxycodone/aspirin properly.
- If you miss a dose of oxycodone/aspirin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use oxycodone/aspirin.
Important safety information:
- Oxycodone/aspirin may cause drowsiness, dizziness, lightheadedness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use oxycodone/aspirin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using oxycodone/aspirin; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
- Oxycodone/aspirin may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- The risk of serious breathing problems may be greater if you take oxycodone/aspirin in high doses. Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
- Oxycodone/aspirin may cause stomach bleeding. Your risk may be greater if you drink alcohol while you are using oxycodone/aspirin.
- Oxycodone/aspirin may cause or worsen constipation. To prevent constipation, maintain a diet adequate in fiber, drink plenty of water, and exercise. If you become constipated while taking oxycodone/aspirin, talk with your doctor or pharmacist. A stool softener or fiber laxative may be required.
- Talk to your doctor before you take oxycodone/aspirin if you drink 3 or more drinks with alcohol per day.
- Oxycodone/aspirin may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
- Aspirin has been linked to a serious illness called Reye syndrome. Do not give oxycodone/aspirin to a child or teenager who has the flu, chickenpox, or a viral infection. Do not give oxycodone/aspirin to a child or teenager who has recently received a flu or chickenpox vaccine. Contact your doctor with any questions or concerns.
- Tell your doctor or dentist that you take oxycodone/aspirin before you receive any medical or dental care, emergency care, or surgery.
- Oxycodone/aspirin has aspirin in it. Before you start any new medicine, check the label to see if it has aspirin or another salicylate in it too. If it does or if you are not sure, check with your doctor or pharmacist.
- If you are taking aspirin prescribed by your doctor to prevent heart attack or stroke, check with your doctor to see whether you should continue to take it with oxycodone/aspirin
- Diabetes patients - Oxycodone/aspirin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- Oxycodone/aspirin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking oxycodone/aspirin.
- Use oxycodone/aspirin with caution in the ELDERLY; they may be more sensitive to its effects, especially breathing problems.
- Oxycodone/aspirin should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: Oxycodone/aspirin has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using oxycodone/aspirin while you are pregnant. Avoid using oxycodone/aspirin during the last 3 months of pregnancy. Oxycodone/aspirin is found in breast milk. Do not breast-feed while taking oxycodone/aspirin.
When used for long periods of time or at high doses, oxycodone/aspirin may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if oxycodone/aspirin stops working well. Do not take more than prescribed.
Some people who use oxycodone/aspirin for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction.
If you suddenly stop taking oxycodone/aspirin, you may have WITHDRAWAL symptoms. These may include anxiety, backache, chills, diarrhea, enlarged pupils, fast breathing, fast heartbeat, increased tearing, irritability, joint pain, loss of appetite, muscle pain, nausea, restlessness, runny nose, stomach cramps, sweating, trouble sleeping, vomiting, weakness, or yawning.
Possible side effects of oxycodone/ aspirin:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Constipation; dizziness; drowsiness; heartburn; lightheadedness; nausea; stomach upset; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody or black stools; confusion; dark urine; decreased or difficult urination; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; hallucination; hearing loss; mood or mental changes; muscle pain, weakness, or cramps; one-sided weakness; ringing in the ears; seizures; severe dizziness, drowsiness, headache, or lightheadedness; severe or persistent constipation, heartburn, or stomach pain; shortness of breath; slow or shallow breathing; trouble swallowing; unusual bruising or bleeding; vision or speech problems; vomit that looks like coffee grounds; wheezing; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include chest pain; cold and clammy skin; coma; confusion; dehydration; depression; enlarged or decreased pupil size; fever; loss of consciousness; ringing in the ears or trouble hearing; severe drowsiness, dizziness, lightheadedness, nausea, vomiting, or diarrhea; severe weakness; slow, shallow, or difficult breathing; slow heartbeat.Proper storage of oxycodone/aspirin:
Store oxycodone/aspirin at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep oxycodone/aspirin out of the reach of children and away from pets.
- If you have any questions about oxycodone/aspirin, please talk with your doctor, pharmacist, or other health care provider.
- Oxycodone/aspirin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take oxycodone/aspirin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about oxycodone/aspirin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to oxycodone/aspirin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using oxycodone/aspirin.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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