Generic Name: oxymorphone (OX-i-MOR-fone)
Brand Name: Opana
Numorphan is used for:
Treating moderate to severe pain. It may be used before surgery to cause sedation and reduce anxiety. It may also be used for other conditions as determined by your doctor.
Numorphan is a narcotic pain reliever. It works in the brain and nervous system to reduce pain. It may also affect other body systems (eg, respiratory, circulatory) at higher doses.
Do NOT use Numorphan if:
- you are allergic to any ingredient in Numorphan or any other codeine- or morphine-related medicine (eg, oxycodone)
- you have known or suspected stomach or bowel blockage (eg, paralytic ileus)
- you have slow or difficult breathing, fluid in the lungs due to chemical irritation, high levels of carbon dioxide in the blood (hypercapnia or hypercarbia), or severe asthma, or you are having an asthma attack
- you have moderate to severe liver problems
- you are taking mixed agonist/antagonist analgesic medicines (eg, buprenorphine, butorphanol, pentazocine) or sodium oxybate (GHB)
- you are taking or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days
Contact your doctor or health care provider right away if any of these apply to you.
Before using Numorphan:
Some medical conditions may interact with Numorphan. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of chronic obstructive pulmonary disease (COPD) or other lung or breathing problems (eg, asthma, emphysema, bronchitis), sleep apnea, curvature of the spine (eg, kyphoscoliosis), heart problems (eg, cor pulmonale), hypercapnia or hypercarbia, low levels of oxygen in the blood (hypoxia), low blood pressure, dehydration, or low blood volume
- if you have severe drowsiness, a recent head injury, increased pressure in the brain, growths in the brain (eg, tumors), or a history of seizures
- if you have liver or kidney problems, thyroid problems, adrenal gland problems (eg, Addison disease), stomach pain, stomach or bowel problems (eg, inflammation), gallbladder or pancreas problems, a blockage of the bladder, trouble urinating, constipation, or an enlarged prostate, or if you have had recent stomach or bowel surgery
- if you drink alcohol, have symptoms of alcohol withdrawal, or have a history of suicidal thoughts or attempts
- if you or a member of your family has a history of mood or mental problems (eg, anxiety, depression, hallucinations), or alcohol or other substance abuse or dependence
- if you have poor health or are in shock, are very overweight, or have recently had or will be having surgery
- if you are taking carisoprodol
Some MEDICINES MAY INTERACT with Numorphan. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Phenothiazines (eg, chlorpromazine) because the risk of low blood pressure may be increased
- Cimetidine or sodium oxybate (GHB) because the risk of side effects, such as severe drowsiness, slow or difficult breathing, coma, or confusion, may be increased
- Anticholinergics (eg, scopolamine, benztropine) because the risk of severe constipation or trouble urinating may be increased
- MAOIs (eg, phenelzine) because the risk of a severe reaction, including fever, seizures, and coma, may be increased
- Mixed agonist/antagonist analgesics (eg, buprenorphine, butorphanol, nalbuphine, pentazocine) or naltrexone because they may decrease Numorphan's effectiveness and withdrawal may occur
This may not be a complete list of all interactions that may occur. Ask your health care provider if Numorphan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Numorphan:
Use Numorphan as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Numorphan is usually administered as an injection at your doctor's office, hospital, or clinic. If you will be using Numorphan at home, a health care provider will teach you how to use it. Be sure you understand how to use Numorphan. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use Numorphan if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you have been taking Numorphan regularly, do not suddenly stop taking Numorphan. You may have an increased risk of withdrawal symptoms (eg, nausea, sweating, pain). If you need to stop Numorphan, your doctor will gradually lower your dose.
- Numorphan is usually used as needed. If you forget to use a dose of Numorphan and you still have pain, use it when you remember as directed by your doctor. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Numorphan.
Important safety information:
- Numorphan may cause dizziness, drowsiness, blurred vision, or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Use Numorphan with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do not drink alcohol or take medicines (prescription or nonprescription) that contain alcohol while you are using Numorphan. Check with your pharmacist if you have questions about whether any of your medicines contain alcohol.
- Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Numorphan; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
- Numorphan may cause dizziness, light-headedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, light-headedness, or weakness.
- Numorphan may be habit forming. Do NOT take more than the recommended dose, change your dose, use more often than prescribed, or use for longer than prescribed without checking with your doctor. Misuse or abuse of Numorphan may cause severe side effects, including severe breathing problems, seizures, coma, and possibly death.
- Numorphan may cause constipation. Talk with your doctor or pharmacist about using a stool softener or laxative to prevent constipation. It is also important to maintain a diet adequate in fiber, drink plenty of water, and exercise to prevent constipation. If you become constipated while taking Numorphan, talk with your doctor or pharmacist.
- If your pain continues or becomes worse, or if you have side effects that concern you, contact your doctor.
- Tell your doctor or dentist before you receive any medical or dental care, emergency care, or surgery.
- Use Numorphan with caution in the ELDERLY; they may be more sensitive to its effects, especially breathing problems, drowsiness, dizziness, confusion, and nausea.
- Use Numorphan with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY AND BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Numorphan while you are pregnant. Long-term use of Numorphan during pregnancy may cause dependence in the fetus or newborn. Discuss any questions or concerns with your doctor. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you are using Numorphan, check with your doctor. Discuss any possible risks to your baby.
When used for long periods of time or at high doses, Numorphan may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Numorphan stops working well. Do not take more than prescribed.
When used for long periods of time or at high doses, some people develop a need to continue taking Numorphan. This is known as DEPENDENCE or addiction.
If you are taking Numorphan regularly, do not suddenly stop taking it without checking with your doctor. WITHDRAWAL symptoms have occurred when Numorphan is suddenly stopped and may include anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea and vomiting; pain; rigid muscles; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping. Contact your doctor if you notice any of these symptoms after stopping Numorphan.
Possible side effects of Numorphan:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Constipation; dizziness; drowsiness; dry mouth; headache; mild itching; nausea; sweating; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; confusion; fainting; fast, slow, or irregular heartbeat; fever; hallucinations; mental or mood changes (eg, agitation, depression); seizures; severe or persistent constipation, stomach pain, or vomiting; severe or persistent dizziness, drowsiness, or headache; shallow, slowed, or difficult breathing; shortness of breath; trouble urinating; unusual swelling; vision changes (eg, blurred vision).
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include bluish skin; chest, jaw, or arm pain; cold and clammy skin; coma; difficult, shallow, or slow breathing; fainting; limp muscles; pinpoint pupils; severe drowsiness or dizziness; shortness of breath; slow or irregular heartbeat; sudden, severe nausea or vomiting; sudden, unusual sweating or weakness.Proper storage of Numorphan:
Numorphan is usually handled and stored by a health care provider. If you are using Numorphan at home, store Numorphan as directed by your pharmacist or health care provider. Keep Numorphan out of the reach of children and away from pets.
- If you have any questions about Numorphan, please talk with your doctor, pharmacist, or other health care provider.
- Numorphan is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Numorphan or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Numorphan. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Numorphan. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Numorphan.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about Numorphan (oxymorphone)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
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- Drug class: narcotic analgesics