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Noxafil

Generic Name: posaconazole (POE-sa-KON-a-zole)
Brand Name: Noxafil

Noxafil is used for:

Preventing certain types of fungal infections in patients with severely weakened immune systems. It may also be used for other conditions as determined by your doctor.

Noxafil is an azole antifungal. It works by killing sensitive fungi by interfering with the formation of the fungal cell membrane.

Do NOT use Noxafil if:

  • you are allergic to any ingredient in Noxafil or to other azole antifungals (eg, fluconazole, ketoconazole, itraconazole, voriconazole)
  • you are taking atorvastatin, an ergot alkaloid (eg, ergotamine, dihydroergotamine), lovastatin, pimozide, quinidine, simvastatin, or sirolimus

Contact your doctor or health care provider right away if any of these apply to you.

Before using Noxafil:

Some medical conditions may interact with Noxafil. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of liver problems, kidney problems, blood vessel problems (eg, in the heart), or heart problems (eg, irregular heartbeat, abnormal heart function tests)
  • if you have blood electrolyte problems (eg, low blood potassium, magnesium, calcium levels)
  • If you have low blood platelet or neutrophil levels, HIV, or a weakened immune system, or you take medicine that may weaken your immune system (eg, cyclosporine, tacrolimus)
  • if you take any medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat

Some MEDICINES MAY INTERACT with Noxafil. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Many prescription and nonprescription medicines (eg, used for allergies, anxiety, asthma or other lung or breathing problems, birth control, blood thinning, cancer, cystic fibrosis, depression or other mental or mood problems, diabetes, enlarged prostate gland, erectile dysfunction, gout, heartburn, high blood pressure, high blood prolactin levels, high cholesterol, HIV infection, immune system suppression, infections, irregular heartbeat or other heart problems, migraine headaches, overactive bladder, overactive parathyroid gland, pain, seizures, sleep, stomach or bowel problems, Tourette disorder), multivitamin products, or herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort) because they may interact with Noxafil. Ask your doctor or pharmacist if you are unsure if any of your medicines might interact with Noxafil.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Noxafil may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Noxafil:

Use Noxafil as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Noxafil. Talk to your pharmacist if you have questions about this information.
  • Noxafil is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Noxafil at home, a health care provider will teach you how to use it. Be sure you understand how to use Noxafil. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Noxafil if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Use Noxafil on a regular schedule to get the most benefit from it.
  • Using Noxafil at the same time each day will help you remember to take it.
  • Continue to use Noxafil even if you feel well. Do not miss any doses.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Noxafil, call your doctor to find out what to do.

Ask your health care provider any questions you may have about how to use Noxafil.

Important safety information:

  • Serious and sometimes fatal liver problems have been reported with the use of Noxafil. Contact your doctor right away if you develop symptoms of liver problems, such as nausea, vomiting, loss of appetite, fever, stomach pain, yellowing of the skin or eyes, dark urine, pale stools, itching, or unusual tiredness or achiness. Discuss any questions or concerns with your doctor.
  • Noxafil only works against fungi; it does not treat viral infections (eg, the common cold) or bacterial infections.
  • Be sure to use Noxafil for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The fungus could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Long-term or repeated use of Noxafil may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
  • Diabetes patients - Noxafil may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Tell your doctor or dentist that you take Noxafil before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests may be performed while you use Noxafil. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Noxafil should not be used in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is not known if Noxafil can cause harm to the fetus. If you become pregnant, contact your doctor right away. You will need to discuss the benefits and risks of using Noxafil while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking Noxafil.

Possible side effects of Noxafil:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; cough; decreased appetite; diarrhea; headache; mild fever; mild stomach pain; nausea; tiredness; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); burning, numbness, or tingling; chest pain; coughing up blood; decreased urination; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; muscle aches, pain, spasms, weakness, or cramping; nosebleeds; seizures; severe or persistent headache or dizziness; severe or persistent nausea, vomiting, diarrhea, or stomach pain; severe or persistent tiredness or weakness; shortness of breath; sluggishness; swelling of the ankles, feet, hands, arms, or legs; tremor; unusual bruising or bleeding; unusual vaginal bleeding.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Noxafil:

Store Noxafil in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Keep Noxafil out of the reach of children and away from pets.

General information:

  • If you have any questions about Noxafil, please talk with your doctor, pharmacist, or other health care provider.
  • Noxafil is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Noxafil or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Noxafil. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Noxafil. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Noxafil.

Review Date: November 3, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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