NovoLog Mix 70/ 30 cartridges
Generic Name: insulin aspart protamine/insulin aspart (IN-su-lin AS-part PROE-ta-meen)
Brand Name: NovoLog Mix 70/30
NovoLog Mix 70/ 30 cartridges are used for:
Treating diabetes mellitus.
NovoLog Mix 70/30 cartridges are a combination of an intermediate-acting and a fast-acting form of the hormone insulin. It works by helping your body to use sugar properly. This lowers the amount of glucose in the blood, which helps to treat diabetes.
Do NOT use NovoLog Mix 70/ 30 cartridges if:
- you are allergic to any ingredient in NovoLog Mix 70/30 cartridges
- you are having an episode of low blood sugar
Contact your doctor or health care provider right away if any of these apply to you.
Before using NovoLog Mix 70/ 30 cartridges:
Some medical conditions may interact with NovoLog Mix 70/30 cartridges. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you drink alcoholic beverages or smoke
- if you have heart problems (eg, heart failure); kidney or liver problems; nerve problems; adrenal, pituitary, or thyroid problems; or diabetic ketoacidosis
- if you use 3 or more insulin injections per day
- if you are fasting, are on a low-salt (sodium) diet, have blood electrolyte problems (eg, high blood sodium levels, low blood potassium levels), or you exercise
Some MEDICINES MAY INTERACT with NovoLog Mix 70/30 cartridges. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), disopyramide, fenfluramine, fibrates (eg, clofibrate, gemfibrozil), fluoxetine, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), oral medicines for diabetes (eg, glipizide, metformin, nateglinide), pentamidine, pramlintide, propoxyphene, salicylates (eg, aspirin), somatostatin analogs (eg, octreotide), or sulfonamide antibiotics (eg, sulfamethoxazole) because the risk of low blood sugar may be increased
- Beta-blockers (eg, propranolol), clonidine, guanethidine, lithium, or reserpine because they may increase the risk of high or low blood sugar or may hide the signs and symptoms of low blood sugar, if it occurs
- Thiazolidinediones (eg, pioglitazone, rosiglitazone) because the risk of heart failure may be increased
- Atypical antipsychotics (eg, risperidone), corticosteroids (eg, prednisone), danazol, diuretics (eg, furosemide, hydrochlorothiazide), estrogen, hormonal contraceptives (eg, birth control pills), isoniazid, niacin, phenothiazines (eg, chlorpromazine), progesterones (eg, medroxyprogesterone), somatropin, sympathomimetics (eg, albuterol, epinephrine, terbutaline), or thyroid hormones (eg, levothyroxine) because they may decrease NovoLog Mix 70/30 cartridges's effectiveness, resulting in high blood sugar
This may not be a complete list of all interactions that may occur. Ask your health care provider if NovoLog Mix 70/30 cartridges may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use NovoLog Mix 70/ 30 cartridges:
Use NovoLog Mix 70/30 cartridges as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with NovoLog Mix 70/30 cartridges. Talk to your pharmacist if you have questions about this information.
- Use NovoLog Mix 70/30 cartridges within 15 minutes before meals, unless directed otherwise by your doctor.
- If you will be using NovoLog Mix 70/30 cartridges at home, a health care provider will teach you how to use it. Be sure you understand how to use NovoLog Mix 70/30 cartridges. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Carefully shake or rotate the vial, cartridge, or prefilled syringe as directed before each injection. This will ensure that the contents are evenly mixed. This combination insulin should look uniformly cloudy or milky.
- Do not use NovoLog Mix 70/30 cartridges if it contains particles, is discolored, or if the vial or container is cracked or damaged.
- Use the proper technique taught to you by your doctor. Inject deep under the skin, NOT into muscle or a vein.
- Injection sites within an injection area (abdomen, buttock, thigh, upper arm) must be rotated from one injection to the next. Do not inject insulin into skin that is red, swollen, or itchy.
- Do not mix this insulin together with any other type of insulin or any other medicine in the same syringe. Do not use NovoLog Mix 70/30 cartridges in an insulin pump.
- Be sure you have purchased the correct insulin. Insulin comes in a variety of containers, including vials, cartridges, and pens. Make sure that you understand how to properly measure and prepare your dose. If you have any questions about measuring and preparing your dose, contact your doctor or pharmacist for information.
- NovoLog Mix 70/30 cartridges begins lowering blood sugar within 15 minutes after an injection. The peak effect occurs from 1 to 4 hours after a dose. The effects last up to 24 hours.
- Do not share pen or cartridge devices with another person. Sharing these devices may pass infections from one person to another. This includes infections you may not know you have.
- Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- It is very important to follow your insulin regimen exactly. Do NOT miss any doses. Ask your doctor for specific instructions to follow in case you ever miss a dose of insulin.
Ask your health care provider any questions you may have about how to use NovoLog Mix 70/30 cartridges.
Important safety information:
- Drowsiness, dizziness, light-headedness, or blurred vision may occur while you use NovoLog Mix 70/30 cartridges. These effects may be worse if you use it with alcohol or certain medicines. Use NovoLog Mix 70/30 cartridges with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do not drink alcohol without discussing it with your doctor. Drinking alcohol may increase the risk of developing high or low blood sugar.
- Do NOT use more than the recommended dose, use NovoLog Mix 70/30 cartridges more often than prescribed, or change the type or dose of insulin you are using without checking with your doctor.
- Any change of insulin should be made cautiously and only under medical supervision. Changes in purity, strength, brand (manufacturer), type (regular, NPH, lente), species (beef, pork, beef-pork, human), and/or method of manufacture may require a change in dose.
- Stress or illness, especially with nausea and vomiting, may cause your insulin requirements to change. Even if you are not eating, you still require insulin. You and your doctor should establish a sick day plan to use in case of illness. When you are sick, test your blood/urine frequently and call your doctor as instructed.
- Tell your doctor or dentist that you take NovoLog Mix 70/30 cartridges before you receive any medical or dental care, emergency care, or surgery.
- If you will be traveling across time zones, consult your doctor concerning adjustments in your insulin schedule.
- Carry an ID card at all times that says you have diabetes.
- An insulin reaction resulting from low blood sugar levels (hypoglycemia) may occur if you take too much insulin, skip a meal, or exercise too much. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you more hungry. It is a good idea to carry a reliable source of glucose (eg, tablets, gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar such as table sugar, honey, candy, orange juice, or nondiet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.
- Developing a fever or infection, eating significantly more than prescribed, or missing your dose of insulin may cause high blood sugar (hyperglycemia). High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
- Check with your doctor if you notice a depression in the skin or skin thickening at the injection site. You may need to change your injection technique.
- Proper diet, regular exercise, and regular testing of blood sugar are important for best results when using NovoLog Mix 70/30 cartridges. Tell your doctor if you have had a recent change in diet or physical activity.
- Lab tests, including fasting blood glucose and hemoglobin A1c levels, may be performed while you use NovoLog Mix 70/30 cartridges. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use NovoLog Mix 70/30 cartridges with caution in the ELDERLY; if low blood sugar occurs, it may be more difficult to recognize in these patients.
- NovoLog Mix 70/30 cartridges should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using NovoLog Mix 70/30 cartridges while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use NovoLog Mix 70/30 cartridges, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of NovoLog Mix 70/ 30 cartridges:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Back pain; diarrhea; indigestion; redness, swelling, itching, or mild pain at the injection site; runny nose; weight gain.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; wheezing); burning, numbness, or tingling of the arms, hands, legs, or feet; changes in vision; confusion; dizziness; drowsiness; fainting; fast or irregular heartbeat; flu-like symptoms (eg, fever, chills, sore throat); headache; loss of consciousness; mental or mood changes; muscle pain, weakness, or cramping; seizures; shortness of breath; slurred speech; stomach pain; swelling of the hands, ankles, or feet; tremor; trouble concentrating; unusual hunger; unusual sweating; weakness.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include chills; dizziness; drowsiness; fainting; fast or irregular heartbeat; headache; loss of consciousness; nervousness; seizures; shakiness; sweating; tremor; vision changes; weakness.Proper storage of NovoLog Mix 70/30 cartridges:
VIALS: Store new (unopened) vials in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Store used (open) vials either in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C), or at room temperature, below 86 degrees F (30 degrees C). Store away from heat and light. If NovoLog Mix 70/30 cartridges has been frozen or overheated, throw it away. Throw away unrefrigerated or opened vials after 28 days, even if they still contain medicine.
CARTRIDGE SYSTEMS and PREFILLED SYRINGES: Store new (unopened) cartridge systems or prefilled syringes in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Store used (open) cartridge systems or prefilled syringes at room temperature, below 86 degrees F (30 degrees C). Do NOT store used (open) cartridges or prefilled syringes in the refrigerator. Store away from heat and light. If NovoLog Mix 70/30 cartridges has been frozen or overheated, throw it away. Throw away unrefrigerated or used cartridge systems or prefilled syringes after 14 days, even if they still contain medicine.
Do not leave NovoLog Mix 70/30 cartridges in a car on a warm or sunny day. Do not use NovoLog Mix 70/30 cartridges after the expiration date stamped on the label. Keep NovoLog Mix 70/30 cartridges, as well as syringes and needles, out of the reach of children and away from pets.
- If you have any questions about NovoLog Mix 70/30 cartridges, please talk with your doctor, pharmacist, or other health care provider.
- NovoLog Mix 70/30 cartridges are to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take NovoLog Mix 70/30 cartridges or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about NovoLog Mix 70/30 cartridges. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to NovoLog Mix 70/30 cartridges. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using NovoLog Mix 70/30 cartridges.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about NovoLog Mix 70/30 (insulin aspart / insulin aspart protamine)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
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- Drug class: insulin