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Niaspan controlled-release tablets
Generic Name: niacin (NYE-a-sin)
Brand Name: Niaspan
Niaspan controlled-release tablets are used for:
Improving cholesterol levels and lowering very high serum triglyceride levels. It is also used to reduce the risk of a second heart attack or slow or treat hardening of the arteries in certain patients with high cholesterol. Niaspan controlled-release tablets are used in combination with diet. It may be used alone or with other medicines. It may also be used for other conditions as determined by your doctor.
Niaspan controlled-release tablets are an antihyperlipidemic. It works by reducing low-density lipoprotein (LDL) ("bad") cholesterol and triglycerides, and increasing high-density lipoprotein (HDL) ("good") cholesterol.
Do NOT use Niaspan controlled-release tablets if:
- you are allergic to any ingredient in Niaspan controlled-release tablets
- you have liver problems, unexplained abnormal liver function tests, a stomach ulcer, or a certain bleeding problem (arterial bleeding)
Contact your doctor or health care provider right away if any of these apply to you.
Before using Niaspan controlled-release tablets:
Some medical conditions may interact with Niaspan controlled-release tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of chest pain (angina), diabetes, gallbladder problems, glaucoma, gout, heart problems or a recent heart attack, kidney or liver problems, jaundice (yellowing of the skin or eyes), low blood pressure, low phosphate levels, muscle problems (eg, rhabdomyolysis), stomach problems (eg, peptic ulcers), or thyroid problems
- if you have a history of bleeding problems
- if you consume large amounts of alcohol or if you will be having surgery
- if you take aspirin, vitamins, or supplements that contain niacin or nicotinamide
Some MEDICINES MAY INTERACT with Niaspan controlled-release tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Anticoagulants (eg, warfarin) because side effects, such as bleeding, may occur
- Fibrates (eg, gemfibrozil, fenofibrate) or HMG-CoA reductase inhibitors ("statins") (eg, lovastatin, simvastatin) because side effects, such as muscle aches and weakness that may be a symptom of a serious medical condition called rhabdomyolysis, may occur
- Calcium channel blockers (eg, amlodipine), nitrates (eg, isosorbide dinitrate), or other medicines for high blood pressure (eg, clonidine, prazosin) because side effects, such as dizziness and very low blood pressure, may occur
- Alcohol because toxic effects, such as delirium and lactic acidosis, may occur
This may not be a complete list of all interactions that may occur. Ask your health care provider if Niaspan controlled-release tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Niaspan controlled-release tablets:
Use Niaspan controlled-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Niaspan controlled-release tablets. Talk to your pharmacist if you have questions about this information.
- To minimize flushing and upset stomach, take Niaspan controlled-release tablets at bedtime after a low-fat snack (eg, low-fat yogurt, banana, crackers with a glass of milk) unless your doctor directs otherwise. Do not take Niaspan controlled-release tablets on an empty stomach. Do not take Niaspan controlled-release tablets with alcohol, a hot drink, or spicy foods.
- Do not take bile acid sequestrants (eg, colestipol, cholestyramine) within 4 to 6 hours of taking Niaspan controlled-release tablets.
- Swallow Niaspan controlled-release tablets whole. Do not break, crush, or chew before swallowing.
- If you miss a dose of Niaspan controlled-release tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you miss several doses, contact your doctor.
Ask your health care provider any questions you may have about how to use Niaspan controlled-release tablets.
Important safety information:
- Niaspan controlled-release tablets may cause dizziness or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Niaspan controlled-release tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Niaspan controlled-release tablets may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase this effect. To prevent it, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of this effect.
- Do NOT take more than the recommended dose without checking with your doctor.
- Niaspan controlled-release tablets may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
- Do not substitute Niaspan controlled-release tablets for any other type of niacin without talking with your doctor. Severe liver damage can occur.
- If you stop taking Niaspan controlled-release tablets for an extended period, contact your doctor before you start taking it again. Your dose may need to be adjusted.
- Tell your doctor or dentist that you take Niaspan controlled-release tablets before you receive any medical or dental care, emergency care, or surgery.
- Follow the diet and exercise program given to you by your health care provider.
- Flushing occurs with Niaspan controlled-release tablets and may last for several hours. Take Niaspan controlled-release tablets at bedtime so that flushing will occur during sleep, unless your doctor tells you otherwise. If you are awakened by flushing at night, get up slowly, especially if you feel dizzy or faint, or if you are taking blood pressure medicines. Taking aspirin 30 minutes before you take Niaspan controlled-release tablets may lessen flushing. Talk with your doctor to see if you should take aspirin before you take Niaspan controlled-release tablets or if flushing becomes bothersome.
- Diabetes patients - Niaspan controlled-release tablets may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.
- Diabetes patients - Niaspan controlled-release tablets may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- Report any unexplained muscle pain, tenderness, or weakness to your doctor right away, especially if you also have a fever or general body discomfort.
- Niaspan controlled-release tablets may interfere with certain lab tests, including plasma or urinary catecholamine tests or urine glucose tests. Be sure your doctor and lab personnel know you are taking Niaspan controlled-release tablets.
- Lab tests, including liver function, blood glucose, blood potassium, and serum creatine phosphokinase, may be performed while you use Niaspan controlled-release tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Niaspan controlled-release tablets with caution in the ELDERLY; they may be more sensitive to its effects, especially muscle problems.
- Niaspan controlled-release tablets should be used with extreme caution in CHILDREN younger than 16 years old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Niaspan controlled-release tablets while you are pregnant. Niaspan controlled-release tablets are found in breast milk. Do not breast-feed while taking Niaspan controlled-release tablets.
Possible side effects of Niaspan controlled-release tablets:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Diarrhea; dizziness; headache; heartburn; increased cough, indigestion, or upset stomach; nausea; temporary skin redness, itching, tingling, or feelings of warmth (flushing); vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); black, tarry, or bloody stools; changes in vision (eg, cloudy or blurred vision); decrease in urine or dark-colored urine; fainting; fast or irregular heartbeat; fever or chills; flu-like symptoms (eg, chills, fever, persistent sore throat); increased sweating; loss of appetite; muscle pain, tenderness, swelling, or weakness (with or without fever and fatigue); numbness or persistent tingling of the skin; pale stools; severe dizziness or headache; severe or persistent diarrhea, nausea, or vomiting; shortness of breath; stomach pain; swelling of the hands, legs, or feet; symptoms of high blood sugar (eg, increased thirst, hunger, or urination, confusion, drowsiness rapid breathing, fruit-like breath odor); unusual bruising or bleeding; unusual tiredness; vomit that looks like coffee grounds; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include flushing.Proper storage of Niaspan controlled-release tablets:
Store Niaspan controlled-release tablets at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Niaspan controlled-release tablets out of the reach of children and away from pets.
- If you have any questions about Niaspan controlled-release tablets, please talk with your doctor, pharmacist, or other health care provider.
- Niaspan controlled-release tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Niaspan controlled-release tablets or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Niaspan controlled-release tablets. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Niaspan controlled-release tablets. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Niaspan controlled-release tablets.