The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content.
Generic Name: trimetrexate (TRY-meh-TREK-sate)
Brand Name: Neutrexin
Neutrexin must be used with another medicine called leucovorin to protect against potentially serious or life-threatening reactions, such as kidney or liver problems; infected stomach, intestinal or mouth sores; or a decreased ability to fight infections.
Neutrexin is used for:
Treating moderate to severe Pneumocystis carinii pneumonia (PCP) in patients with weak immune systems, including those with AIDS, who are not able to take the standard treatment. Neutrexin is used in combination with leucovorin.
Neutrexin is an anti-infective agent. It works by inhibiting DNA, RNA, and protein synthesis, leading to cell death.
Do NOT use Neutrexin if:
- you are allergic to any ingredient in Neutrexin, leucovorin, or methotrexate
- you are taking a nonsteroidal anti-inflammatory drug (NSAID) (eg, ibuprofen) or pristinamycin
Contact your doctor or health care provider right away if any of these apply to you.
Before using Neutrexin:
Some medical conditions may interact with Neutrexin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have bone marrow depression, a blood disorder, or kidney or liver problems
Some MEDICINES MAY INTERACT with Neutrexin. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Cisplatin, corticosteroids (eg, prednisone), cyclosporine, etretinate, NSAIDs (eg, ibuprofen), penicillins (eg, amoxicillin), pristinamycin, probenecid, quinolones (eg, ciprofloxacin), salicylates (eg, aspirin), sulfonamides (eg, sulfamethoxazole), tetracyclines (eg, doxycycline), or trimethoprim because the actions and side effects of Neutrexin may be increased, possibly leading to toxicities
- Digoxin or hydantoins (eg, phenytoin) because the effectiveness of these medicines may be decreased
This may not be a complete list of all interactions that may occur. Ask your health care provider if Neutrexin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Neutrexin:
Use Neutrexin as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Neutrexin is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Neutrexin at home, carefully follow the injection procedures taught to you by your health care provider.
- Neutrexin should not be given at the same time as fluorouracil. Doses should be separated as directed.
- If Neutrexin contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
- Neutrexin must be used with another medicine, leucovorin, as protection against potentially serious or life-threatening reactions. Treatment with leucovorin must extend 72 hours past the last dose of Neutrexin. Use all leucovorin doses as instructed. If you fail to use the correct dose and all doses of leucovorin, it may cause fatal toxicity.
- Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
- If you miss a dose of Neutrexin, contact your doctor immediately.
Ask your health care provider any questions you may have about how to use Neutrexin.
Important safety information:
- Do not drink alcohol while you are using Neutrexin.
- Neutrexin may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
- Neutrexin may lower your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection including fever, sore throat, rashes, or chills.
- LAB TESTS, including neutrophil counts, platelet counts, liver function, and kidney function, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
- Use Neutrexin with caution in the ELDERLY because they may be more sensitive to its effects.
- Neutrexin is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.
- PREGNANCY and BREAST-FEEDING: Neutrexin has been shown to cause harm to the fetus. Avoid becoming pregnant while taking Neutrexin. If you think you may be pregnant, discuss with your doctor the benefits and risks of using Neutrexin during pregnancy. It is unknown if Neutrexin is excreted in breast milk. Do not breast-feed while taking Neutrexin.
Possible side effects of Neutrexin:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chills; drops in counts of blood cells; fever; itching; nausea; sores in mouth; symptoms of a new infection; unusual bruising or bleeding; unusual tiredness or weakness; vomiting; yellow discoloration of skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blood disorders.Proper storage of Neutrexin:
Store Neutrexin at room temperature, between 68 to 77 degrees F (20 to 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Neutrexin out of the reach of children and away from pets.
- If you have any questions about Neutrexin, please talk with your doctor, pharmacist, or other health care provider.
- Neutrexin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Neutrexin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Neutrexin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Neutrexin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Neutrexin.