Generic Name: fosinopril/hydrochlorothiazide (fos-IN-oh-pril/HYE-droe-KLOR-oh-THYE-a-zide)
Brand Name: Monopril HCT
Monopril HCT can cause injury or death to the fetus if taken during pregnancy. If you think you may be pregnant, contact your doctor right away. If you are planning to become pregnant, talk with your doctor about other treatment options.
Monopril HCT is used for:
Treating high blood pressure.
Monopril HCT is an angiotensin-converting enzyme (ACE) inhibitor and thiazide diuretic combination. It works to lower your blood pressure by removing excess fluid from the body and causing blood vessels to relax or widen.
Do NOT use Monopril HCT if:
- you are allergic to any ingredient in Monopril HCT, other sulfonamide medicines (eg, sulfamethoxazole, glyburide, probenecid), or other ACE inhibitors (eg, lisinopril)
- you have a history of angioedema (swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or unusual hoarseness), including angioedema caused by treatment with an ACE inhibitor
- you are unable to urinate
- you are pregnant
- you are taking a medicine that contains aliskiren and you also have diabetes or kidney problems. Check with your doctor or pharmacist if you are not sure if a medicine you take contains aliskiren
- you are also taking dofetilide or ketanserin
Contact your doctor or health care provider right away if any of these apply to you.
Before using Monopril HCT:
Some medical conditions may interact with Monopril HCT. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are able to become pregnant
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of heart problems (eg, heart failure, aortic stenosis), blood vessel problems, blood flow problems, bone marrow problems, kidney or liver problems, high blood cholesterol or lipid levels, diabetes, or gout
- if you have a history of a stroke, a recent heart attack, kidney transplant, allergies, or asthma
- if you have an autoimmune disease (eg, rheumatoid arthritis, lupus, scleroderma)
- if you are dehydrated, have low blood volume, severe diarrhea or vomiting, or low blood pressure
- if you have high blood potassium levels, low blood sodium levels, or are on a low-salt (sodium) diet
- if you are receiving treatments to reduce sensitivity to bee or wasp stings
- if you are having dialysis or apheresis, or are scheduled to have surgery or receive anesthesia
- if you have recently had a certain type of nerve surgery (sympathectomy)
- if you have never taken another medicine for high blood pressure
Some MEDICINES MAY INTERACT with Monopril HCT. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Digoxin, dofetilide, or ketanserin because the risk of irregular heartbeat may be increased
- Everolimus or sirolimus because the risk of angioedema may be increased
- Adrenocorticotropic hormone (ACTH), corticosteroids (eg, prednisone), dextran sulfate, diazoxide, diuretics (eg, furosemide), or other medicines for high blood pressure because they may increase the risk of Monopril HCT's side effects, including low blood pressure and blood potassium problems
- Aliskiren or angiotensin receptor blockers (ARBs) (eg, losartan) because the risk of certain side effects (eg, kidney problems, high blood potassium levels, low blood pressure) may be increased
- Eplerenone, potassium-sparing diuretics (eg, spironolactone, triamterene), potassium supplements, salt substitutes containing potassium, or trimethoprim because the risk of high blood potassium levels may be increased
- Certain gold-containing medicines (eg, sodium aurothiomalate) because flushing, nausea, vomiting, and low blood pressure may occur
- Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, celecoxib, ibuprofen, indomethacin) because the risk of serious damage to the kidneys (eg, decrease in amount of urine produced) may be increased or they may decrease Monopril HCT's effectiveness
- Lithium or thiopurines (eg, azathioprine) because the risk of their side effects may be increased by Monopril HCT
- Insulin or other diabetes medicines (eg, glyburide), or methenamine because their effectiveness may be decreased by Monopril HCT
This may not be a complete list of all interactions that may occur. Ask your health care provider if Monopril HCT may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Monopril HCT:
Use Monopril HCT as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Monopril HCT by mouth with or without food.
- Do not take an antacid that has aluminum, magnesium, or simethicone in it within 2 hours before or 2 hours after you take Monopril HCT.
- If you take cholestyramine or colestipol, do not take it at the same time that you take Monopril HCT. Talk with your doctor about how you should take cholestyramine or colestipol with Monopril HCT.
- Take Monopril HCT on a regular schedule to get the most benefit from it.
- Taking Monopril HCT at the same time each day will help you remember to take it.
- Continue to use Monopril HCT even if you feel well. Do not miss any doses.
- If you miss a dose of Monopril HCT, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Monopril HCT.
Important safety information:
- Monopril HCT may cause dizziness, light-headedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Monopril HCT with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Monopril HCT may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Monopril HCT may cause a serious side effect called angioedema. Black patients may be at greater risk of developing this side effect. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness.
- Monopril HCT contains hydrochlorothiazide, a sulfonamide, which can cause certain eye problems (myopia, angle-closure glaucoma). Your risk may be increased if you are allergic to sulfonamide medicines (eg, sulfamethoxazole) or to penicillin antibiotics (eg, amoxicillin). Untreated angle-closure glaucoma can lead to permanent vision loss. If these eye problems occur, symptoms usually occur within hours to weeks of starting Monopril HCT. Contact your doctor immediately if you experience symptoms such as vision changes (eg, decreased vision clearness) or eye pain.
- Check with your doctor before you use a salt substitute or a product that has potassium in it.
- Drink plenty of fluids while taking Monopril HCT and avoid engaging in activities that cause excessive sweating. Dehydration, excessive sweating, vomiting, or diarrhea may lead to a fall in blood pressure. Contact your health care provider at once if any of these occur.
- A persistent, unproductive cough may occur. Tell your doctor if this occurs. If caused by Monopril HCT, recovery is rapid when the medicine is stopped.
- Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
- Tell your doctor or dentist that you take Monopril HCT before you receive any medical or dental care, emergency care, or surgery.
- Monopril HCT may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Monopril HCT. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
- Monopril HCT may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
- Diabetes patients - Monopril HCT may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- Monopril HCT may interfere with certain lab tests, including parathyroid function and digoxin blood levels. Be sure your doctor and lab personnel know you are taking Monopril HCT.
- Lab tests, including blood electrolytes, blood pressure, complete blood cell counts, kidney function, and liver function, may be performed while you use Monopril HCT. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Monopril HCT with caution in the ELDERLY; they may be more sensitive to its effects.
- Monopril HCT should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: Monopril HCT may cause birth defects, or fetal or newborn death if you take it while you are pregnant. Do not become pregnant while you take Monopril HCT. If you think you may be pregnant, contact your doctor right away. Monopril HCT is found in breast milk. Do not breast-feed while taking Monopril HCT.
Possible side effects of Monopril HCT:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Dizziness or light-headedness when sitting up or standing; dry cough.
Severe allergic reactions (rash; hives; itching; difficulty swallowing or breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); blurred vision or other vision changes (eg, vision clearness); change in the amount of urine produced; chest pain; dark urine; difficult or painful urination; drowsiness; dry mouth; eye pain; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; joint pain or swelling; loss of appetite; mental or mood changes (eg, depression); muscle cramps, pain, or weakness; numbness or tingling; one-sided weakness; pale stools; red, swollen, blistered, or peeling skin; restlessness; severe or persistent cough; severe or persistent headache, dizziness, or light-headedness; severe or persistent nausea or vomiting; slurred speech; stomach pain (with or without nausea or vomiting); symptoms of high blood sugar (eg, fast breathing; flushing; fruit-like breath odor; increased thirst, hunger, or urination); symptoms of low blood sodium (eg, confusion, mental or mood changes, seizures, sluggishness); tremor; unusual bruising or bleeding; unusual thirst, tiredness, or weakness; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; severe or persistent dizziness or light-headedness; symptoms of blood electrolyte problems (eg, confusion; irregular heartbeat; mental or mood changes; muscle pain, weakness, or cramping; seizures; sluggishness); symptoms of dehydration (eg, drowsiness; dry eyes; fast heartbeat; nausea; restlessness; unusual thirst, tiredness, or weakness; vomiting).Proper storage of Monopril HCT:
Store Monopril HCT between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Monopril HCT out of the reach of children and away from pets.
- If you have any questions about Monopril HCT, please talk with your doctor, pharmacist, or other health care provider.
- Monopril HCT is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Monopril HCT or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Monopril HCT. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Monopril HCT. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Monopril HCT.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about Monopril HCT (fosinopril / hydrochlorothiazide)
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- Drug class: ACE inhibitors with thiazides