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Mipomersen

Generic Name: Mipomersen (mi poe MER sen)
Brand Name: Kynamro

Medically reviewed by Drugs.com. Last updated on Feb 16, 2019.

Warning

  • This medicine may cause liver problems in some patients. Talk with the doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • You may only get mipomersen through a special program. Talk with your doctor.

Uses of Mipomersen:

  • It is used to lower cholesterol.

What do I need to tell my doctor BEFORE I take Mipomersen?

  • If you have an allergy to mipomersen or any other part of mipomersen.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have liver disease.
  • If you are breast-feeding or plan to breast-feed.

This is not a list of all drugs or health problems that interact with mipomersen.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take mipomersen with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Mipomersen?

  • Tell all of your health care providers that you take mipomersen. This includes your doctors, nurses, pharmacists, and dentists.
  • Talk with your doctor before you drink alcohol.
  • If you are 65 or older, use mipomersen with care. You could have more side effects.
  • This medicine may cause harm to the unborn baby if you take it while you are pregnant.
  • Use birth control that you can trust to prevent pregnancy while taking mipomersen.
  • If you are pregnant or you get pregnant while taking mipomersen, call your doctor right away.

How is this medicine (Mipomersen) best taken?

Use mipomersen as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as a shot into the fatty part of the skin on the top of the thigh, belly area, or upper arm.
  • If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot.
  • Follow how to use as you have been told by the doctor or read the package insert.
  • If stored in a refrigerator, let mipomersen come to room temperature before using it. Leave it at room temperature for at least 30 minutes. Do not heat mipomersen.
  • Give on the same day each week.
  • Wash your hands before and after use.
  • Move the site where you give the shot with each shot.
  • Do not give into red or irritated skin.
  • Do not give into skin that is tattooed or scarred.
  • Do not give into skin that is sunburned.
  • Do not give into skin that is affected by psoriasis.
  • Do not use if the solution is cloudy, leaking, or has particles.
  • Do not use if solution changes color.
  • Do not mix with any other liquid drugs.
  • Each prefilled syringe is for one use only.
  • Throw away any part left over after the dose is given.
  • Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.

What do I do if I miss a dose?

  • If it is 3 or more days to the time of your next dose, take the missed dose as soon as you think about it and go back to your normal day.
  • If it is 1 or 2 days to the time of your next dose, skip the missed dose and go back to your normal day.
  • Do not take 2 doses at the same time or extra doses.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Swelling in the arms or legs.

What are some other side effects of Mipomersen?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Upset stomach.
  • Headache.
  • Feeling tired or weak.
  • Pain in arms or legs.
  • Flu-like signs. These include headache, weakness, fever, shakes, aches, pains, and sweating.
  • It is common to have reactions where the injection is given. This includes pain, redness, itching, bruising, and swelling. Call your doctor if any of these effects are severe, bother you, or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Mipomersen?

  • Store in a refrigerator. Do not freeze.
  • Store in the carton to protect from light.
  • If needed, you may store at room temperature for up to 14 days. Write down the date you take mipomersen out of the refrigerator. If stored at room temperature and not used within 14 days, throw mipomersen away.
  • Protect from heat.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time mipomersen is refilled. If you have any questions about mipomersen, please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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