Generic Name: acetaminophen/dichloralphenazone/isometheptene (a-seet-a-MIN-oh-fen/dye-klor-al-PHEN-a-zone/eye-soe-me-THEP-teen)
Brand Name: Examples include Duradrin and Midrin
Midrin contains acetaminophen. Severe and sometimes fatal liver problems, including the need for liver transplant, have been reported with the use of acetaminophen. Most cases of these liver problems occurred in patients taking excessive doses of acetaminophen (more than 4,000 mg per day). Also, patients who developed these liver problems were often using more than 1 medicine that contained acetaminophen. Discuss any questions or concerns with your doctor.
Midrin is used for:
Treating certain types of headaches (tension, vascular). It may also be used to treat migraine headaches. It may also be used for other conditions as determined by your doctor.
Midrin is a combination analgesic, sedative, and sympathomimetic. It works by decreasing pain, providing sedation, and narrowing the blood vessels in the head and brain.
Do NOT use Midrin if:
- you are allergic to any ingredient in Midrin
- you have glaucoma, severe kidney problems, high blood pressure, heart problems, or liver problems
- you are taking droxidopa or have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the past 14 days
Contact your doctor or health care provider right away if any of these apply to you.
Before using Midrin:
Some medical conditions may interact with Midrin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have alcoholism or if you consume 3 or more alcohol-containing drinks every day
- if you have liver or kidney problems, hepatitis, high blood pressure, heart problems, blood vessel problems (eg, blood vessels in your heart), or the blood disease porphyria
- if you have had a recent heart attack
Some MEDICINES MAY INTERACT with Midrin. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone) or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Midrin's side effects
- Droxidopa because the risk of severe heart problems, including irregular heartbeat or heart attack, may be increased
- Furazolidone or MAOIs (eg, phenelzine) because the risk of severe side effects, such as severe headache, high blood pressure, or high fever, may be increased
- Isoniazid because the risk of liver problems may be increased
- Anticoagulants (eg, warfarin) or bromocriptine because the risk of their side effects may be increased by Midrin
- Guanadrel or guanethidine because their effectiveness may be decreased by Midrin
This may not be a complete list of all interactions that may occur. Ask your health care provider if Midrin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Midrin:
Use Midrin as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Midrin by mouth with or without food.
- For a migraine headache - Take Midrin at the first sign of a headache. If the initial dose does not relieve your headache, additional doses may be needed according to your doctor's instructions. Do not take a dose of Midrin within 60 minutes of your last dose. Do not take more than 5 capsules within a 12-hour period.
- For a tension headache - Do not take more than 8 capsules within a 24-hour period.
- If you miss a dose of Midrin and you still have a headache, take it as soon as you remember. If you need to take additional doses, continue to follow your doctor's dosing instructions. Do not take Midrin more often than directed. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Midrin.
Important safety information:
- Midrin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Midrin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Midrin has acetaminophen in it. Before you start any new medicine, check the label to see if it has acetaminophen in it too. If it does or if you are not sure, check with your doctor or pharmacist.
- Midrin may harm your liver. Your risk may be greater if you drink alcohol while you are using Midrin. Talk to your doctor before you take Midrin or other pain relievers/fever reducers if you drink more than 3 drinks with alcohol per day.
- A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
- Midrin may cause false results with some in-home test kits for blood cholesterol. Check with your doctor or pharmacist if you are taking Midrin and need to check your blood cholesterol at home.
- Midrin should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Midrin while you are pregnant. Midrin is found in breast milk. If you are or will be breast-feeding while you use Midrin, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Midrin:
All medicines may cause side effects, but many people have no, or minor, side effects. If any of the following most COMMON side effects continue or become bothersome, check with your doctor: Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine or pale stools; unusual fatigue; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch .
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include dark urine; excessive sweating; extreme fatigue; nausea and vomiting; stomach pain.Proper storage of Midrin:
Store Midrin at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Midrin out of the reach of children and away from pets.
- If you have any questions about Midrin, please talk with your doctor, pharmacist, or other health care provider.
- Midrin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Midrin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Midrin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Midrin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Midrin.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about Midrin (acetaminophen / dichloralphenazone / isometheptene mucate)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
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