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Generic name: Baclofen Intrathecal InjectionBAK-loe-fen ]
Brand names: Gablofen, Lioresal
Drug class: Skeletal muscle relaxants

Medically reviewed by Last updated on Nov 18, 2023.


  • Unsafe side effects have happened when Lioresal (baclofen intrathecal injection) was stopped all of a sudden. Some of these side effects have been high fever, mental changes, more spasms, and muscle stiffness. Rarely, these side effects have led to very bad muscle problems, organ problems, and death. Avoid stopping Lioresal (baclofen intrathecal injection) all of a sudden without talking with your doctor. Be sure you get your pump refilled on time and you know about the pump alarms and what to do if the pump alarm goes off. Tell your doctor if you have ever had signs of withdrawal while getting baclofen tablets or shot. Call your doctor right away if you have signs of withdrawal.
  • Read the package insert for more details.

Uses of Lioresal:

What do I need to tell my doctor BEFORE I take Lioresal?

This is not a list of all drugs or health problems that interact with Lioresal (baclofen intrathecal injection).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Lioresal (baclofen intrathecal injection) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Lioresal?

How is this medicine (Lioresal) best taken?

Use Lioresal (baclofen intrathecal injection) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

What do I do if I miss a dose?

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

What are some other side effects of Lioresal?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Lioresal?

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.