Generic Name: levoleucovorin calcium (LEE-voe-LOO-koe-VOE-rin KAL-see-um)
Brand Name: Fusilev
Levoleucovorin calcium is used for:
Reducing the toxic effects of methotrexate and certain other medicines (folic acid antagonists). It may also be used for other conditions as determined by your doctor.
Levoleucovorin calcium is a folic acid derivative. It works like folic acid in the body, which helps to reduce the action and toxic effects of folic acid antagonists (eg, methotrexate).
Do NOT use levoleucovorin calcium if:
- you are allergic to any ingredient in levoleucovorin calcium, to folic acid, or to folinic acid
Contact your doctor or health care provider right away if any of these apply to you.
Before using levoleucovorin calcium:
Some medical conditions may interact with levoleucovorin calcium. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have pernicious anemia or other anemia due to low blood levels of vitamin B12
Some MEDICINES MAY INTERACT with levoleucovorin calcium. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Fluorouracil because the risk of its side effects may be increased by levoleucovorin calcium, especially in the elderly
- Phenobarbital, phenytoin, or primidone because their effectiveness may be decreased by levoleucovorin calcium
- Trimethoprim-sulfamethoxazole because its effectiveness may be decreased by levoleucovorin calcium
This may not be a complete list of all interactions that may occur. Ask your health care provider if levoleucovorin calcium may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use levoleucovorin calcium:
Use levoleucovorin calcium as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Levoleucovorin calcium is usually administered as an injection at your doctor's offices or a clinic. Ask your doctor or pharmacist any questions that you may have about levoleucovorin calcium.
- Do not use levoleucovorin calcium if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of levoleucovorin calcium, contact your doctor right away.
Ask your health care provider any questions you may have about how to use levoleucovorin calcium.
Important safety information:
- Lab tests, including blood methotrexate levels, serum creatinine, and complete blood cell counts, may be performed while you use levoleucovorin calcium. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Levoleucovorin calcium should be used with extreme caution in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using levoleucovorin calcium while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use levoleucovorin calcium, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of levoleucovorin calcium:
All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Nausea; sore mouth; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in the amount of urine; confusion.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of levoleucovorin calcium:
Levoleucovorin calcium is usually handled and stored by a health care provider. If you are using levoleucovorin calcium at home, store levoleucovorin calcium as directed by your pharmacist or health care provider. Store away from heat, moisture, and light. Do not store in the bathroom. Keep levoleucovorin calcium out of the reach of children and away from pets.
- If you have any questions about levoleucovorin calcium, please talk with your doctor, pharmacist, or other health care provider.
- Levoleucovorin calcium is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take levoleucovorin calcium or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about levoleucovorin calcium. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to levoleucovorin calcium. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using levoleucovorin calcium.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about levoleucovorin calcium
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- Drug class: antidotes
Other brands: Fusilev