Generic Name: sargramostim (sar-GRA-moe-stim)
Brand Name: Leukine
Leukine is used for:
Reducing severe, life-threatening, or fatal infections after chemotherapy for acute myelogenous leukemia (AML). It is also used to help increase the success of autologous bone marrow transplant and to help increase survival in patients who have bone marrow transplant failure. It may also be used for other conditions as determined by your doctor.
Leukine is a hematopoietic agent. It works by stimulating production of white blood cells in bone marrow.
Do NOT use Leukine if:
- you are allergic to any ingredient in Leukine or to yeast products
- you have certain bone marrow disorders
- you have received chemotherapy or radiation therapy within the last 24 hours or you will be receiving chemotherapy or radiation therapy within the next 24 hours
Contact your doctor or health care provider right away if any of these apply to you.
Before using Leukine:
Some medical conditions may interact with Leukine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have other types of cancer or unusual growths or tumors
- if you have a history of fluid retention, irregular heartbeat, heart disease or congestive heart failure, a lung disorder or breathing problems, or liver or kidney problems
- if you are undergoing radiation therapy or chemotherapy
Some MEDICINES MAY INTERACT with Leukine. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Corticosteroids (eg, prednisone) or lithium because they may increase the risk of Leukine's side effects
This may not be a complete list of all interactions that may occur. Ask your health care provider if Leukine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Leukine:
Use Leukine as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Leukine is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Leukine at home, a health care provider will teach you how to use it. Be sure you understand how to use Leukine. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not shake Leukine.
- Do not use Leukine if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Continue using Leukine for the full course of treatment unless your doctor directs otherwise.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of Leukine, contact your doctor right away.
Ask your health care provider any questions you may have about how to use Leukine.
Important safety information:
- The first dose of Leukine may cause difficulty breathing, flushing, fainting, or fast or irregular heartbeat. These signs usually resolve and usually do not occur again. Contact your doctor for more information.
- Leukine may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Leukine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Diabetes patients - Leukine may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- Lab tests, including liver function, kidney function, blood counts, body weight, and fluid and electrolyte tests, may be performed while you use Leukine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Leukine may have benzyl alcohol in it. Do not use it in NEWBORNS or INFANTS. It may cause serious and sometimes fatal nervous system problems and other side effects.
- PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Leukine, contact your doctor. You will need to discuss the benefits and risks of using Leukine while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you are using Leukine, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Leukine:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Bone, muscle, or joint pain; diarrhea; fever; general feeling of discomfort; hair loss; headache; loss of appetite; mild sweating of the hands, ankles, legs, or feet; nausea; sore mouth; stomach pain; vomiting; weakness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; black or tarry stools; blood in urine; chest pain; emotional or mood changes; fainting; fast or irregular heartbeat; severe or persistent fever; severe stomach pain; severe swelling of the hands, ankles, legs, or feet; shortness of breath; unusual or excessive bleeding; unusual swelling; vomiting blood.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org ), or emergency room immediately. Symptoms may include chills; fast or irregular heartbeat; rash; severe or persistent fever, discomfort, headache, or nausea; shortness of breath.Proper storage of Leukine:
Leukine is usually handled and stored by a health care provider. If you are using Leukine at home, store Leukine as directed by your pharmacist or health care provider. Keep Leukine out of the reach of children and away from pets.
- If you have any questions about Leukine, please talk with your doctor, pharmacist, or other health care provider.
- Leukine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Leukine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Leukine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Leukine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Leukine.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about Leukine (sargramostim)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
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