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Kaletra Tablets

Generic Name: Lopinavir and Ritonavir Tablets (loe PIN a vir/ri TOE na vir)
Brand Name: Kaletra

Medically reviewed on May 2, 2018

Uses of Kaletra:

What do I need to tell my doctor BEFORE I take Kaletra?

  • If you have an allergy to lopinavir, ritonavir, or any other part of Kaletra (lopinavir and ritonavir tablets).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Long QT on ECG or low potassium levels.
  • If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with Kaletra (lopinavir and ritonavir tablets), like certain drugs that are used for high cholesterol, migraines, or mood problems. There are many drugs that must not be taken with Kaletra (lopinavir and ritonavir tablets).
  • If you are taking any drugs that can cause a certain type of heartbeat that is not normal (prolonged QT interval). There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.
  • If you are taking St. John's wort. Do not take St. John's wort with Kaletra (lopinavir and ritonavir tablets). This medicine may not work as well.
  • If you are breast-feeding. Do not breast-feed while you take Kaletra (lopinavir and ritonavir tablets).

This is not a list of all drugs or health problems that interact with Kaletra (lopinavir and ritonavir tablets).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Kaletra (lopinavir and ritonavir tablets) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Kaletra?

For all patients taking Kaletra (lopinavir and ritonavir tablets):

  • Tell all of your health care providers that you take Kaletra (lopinavir and ritonavir tablets). This includes your doctors, nurses, pharmacists, and dentists.
  • This medicine interacts with many other drugs. The chance of Kaletra (lopinavir and ritonavir tablets)'s side effects may be raised or how well Kaletra (lopinavir and ritonavir tablets) works may be lowered. The chance of the other drugs' side effects may also be raised. This may include very bad, life-threatening, or deadly side effects. Check with your doctor and pharmacist to make sure that it is safe for you to take Kaletra (lopinavir and ritonavir tablets) with all of your other drugs (prescription or OTC, natural products, vitamins).
  • High blood sugar has happened with Kaletra (lopinavir and ritonavir tablets). This includes diabetes that is new or worse. Talk with the doctor.
  • Check your blood sugar as you have been told by your doctor.
  • Tell your doctor if you have signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
  • Some people with hemophilia have had times of more bleeding when taking drugs like this one. If you have hemophilia, talk with your doctor.
  • This medicine may cause high cholesterol and triglyceride levels. Talk with the doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • This medicine is not a cure for HIV. Stay under the care of your doctor.
  • This medicine does not stop the spread of diseases like HIV or hepatitis that are passed through blood or having sex. Do not have any kind of sex without using a latex or polyurethane condom. Do not share needles or other things like toothbrushes or razors. Talk with your doctor.
  • Birth control pills and other hormone-based birth control may not work as well to prevent pregnancy. Use some other kind of birth control also like a condom when taking Kaletra (lopinavir and ritonavir tablets).
  • Use with care in children. Talk with the doctor.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Kaletra (lopinavir and ritonavir tablets) while you are pregnant.

Children:

  • If your child's weight changes, talk with the doctor. The dose of Kaletra (lopinavir and ritonavir tablets) may need to be changed.

How is this medicine (Kaletra) best taken?

Use Kaletra (lopinavir and ritonavir tablets) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Keep taking Kaletra (lopinavir and ritonavir tablets) as you have been told by your doctor or other health care provider, even if you feel well.
  • It is important that you do not miss or skip a dose of Kaletra (lopinavir and ritonavir tablets) during treatment.
  • Take with or without food.
  • Swallow tablet whole. Do not chew, break, or crush.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.
  • If you are not sure what to do if you miss a dose, call your doctor.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Chest pain or pressure.
  • Dizziness or passing out.
  • Very upset stomach or throwing up.
  • Any unexplained bruising or bleeding.
  • Change in body fat.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
  • Changes in your immune system can happen when you start taking drugs to treat HIV. If you have an infection that you did not know you had, it may show up when you take Kaletra (lopinavir and ritonavir tablets). Tell your doctor right away if you have any new signs after you start Kaletra (lopinavir and ritonavir tablets), even after taking it for several months. This includes signs of infection like fever, sore throat, weakness, cough, or shortness of breath.
  • Very bad and sometimes deadly liver problems have happened with Kaletra (lopinavir and ritonavir tablets). Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Very bad and sometimes deadly pancreas problems (pancreatitis) have happened with Kaletra (lopinavir and ritonavir tablets). Call your doctor right away if you have very bad stomach pain, very bad back pain, or very upset stomach or throwing up.
  • A type of abnormal heartbeat (prolonged QT interval) can happen with Kaletra (lopinavir and ritonavir tablets). Call your doctor right away if you have a fast heartbeat, a heartbeat that does not feel normal, or if you pass out.

What are some other side effects of Kaletra?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Back pain.
  • Headache.
  • Belly pain.
  • Loose stools (diarrhea).
  • Feeling tired or weak.
  • Upset stomach or throwing up.
  • Muscle or joint pain.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Kaletra?

  • Store tablets in the original container at room temperature. Keep the cap tightly closed. Throw away when the date on bottle has been reached. If stored outside of the original container, throw away any part not used after 2 weeks.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time Kaletra (lopinavir and ritonavir tablets) is refilled. If you have any questions about Kaletra (lopinavir and ritonavir tablets), please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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