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Generic Name: Lomitapide (loe MI ta pide)
Brand Name: Juxtapid

Medically reviewed by Last updated on Jul 15, 2019.


  • This medicine may cause liver problems in some patients. Blood tests will be needed to watch for any liver problems. Talk with the doctor.
  • You may only get Juxtapid (lomitapide) through a special program. Talk with your doctor.

Uses of Juxtapid:

  • It is used to lower cholesterol.

What do I need to tell my doctor BEFORE I take Juxtapid?

  • If you have an allergy to lomitapide or any other part of Juxtapid (lomitapide).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have liver disease or raised liver enzymes.
  • If you have a rare hereditary problem of galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption.
  • If you cannot swallow this product whole.
  • If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with Juxtapid (lomitapide), like certain drugs that are used for HIV, infections, or depression. There are many drugs that must not be taken with Juxtapid (lomitapide). Your doctor or pharmacist can tell you if you are taking a drug that must not be taken with Juxtapid (lomitapide).
  • If you are pregnant or may be pregnant. Do not take Juxtapid (lomitapide) if you are pregnant.
  • If you are breast-feeding or plan to breast-feed.

This is not a list of all drugs or health problems that interact with Juxtapid (lomitapide).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Juxtapid (lomitapide) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Juxtapid?

  • Tell all of your health care providers that you take Juxtapid (lomitapide). This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • If you are taking warfarin, talk with your doctor. You may need to have your blood work checked more closely while you are taking it with Juxtapid (lomitapide).
  • Follow the diet and workout plan that your doctor told you about.
  • Avoid grapefruit and grapefruit juice.
  • Talk with your doctor before you drink alcohol. Do not drink more than 1 alcoholic drink per day.
  • Do not take colesevelam, colestipol, or cholestyramine within 4 hours of Juxtapid (lomitapide).
  • If loose stools (diarrhea) or throwing up happens, other drugs taken by mouth may not get into your body as well. If this happens and you take birth control pills, you will need to use some other kind of birth control also like a condom. Call your doctor if you have loose stools (diarrhea) or throwing up.
  • You may need to take certain supplements like vitamin E and fatty acids while taking Juxtapid (lomitapide). Be sure to follow what your doctor has told you.
  • If you are 65 or older, use Juxtapid (lomitapide) with care. You could have more side effects.
  • This medicine may cause harm to the unborn baby if you take it while you are pregnant.
  • If you are able to get pregnant, a pregnancy test will be done to show that you are NOT pregnant before starting Juxtapid (lomitapide). Talk with your doctor.
  • Use birth control that you can trust to prevent pregnancy while taking Juxtapid (lomitapide).
  • If you are pregnant or you get pregnant while taking Juxtapid (lomitapide), call your doctor right away.

How is this medicine (Juxtapid) best taken?

Use Juxtapid (lomitapide) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take at least 2 hours after the evening meal.
  • Do not take with food. It may cause an upset stomach.
  • Take with a full glass of water.
  • Swallow whole. Do not chew, break, open, or dissolve.

What do I do if I miss a dose?

  • Skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.
  • If the drug is stopped for more than 1 week, talk with the doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Chest pain.
  • A heartbeat that does not feel normal.
  • Flu-like signs.
  • Sometimes, very bad diarrhea has led to the need to go to the hospital. Call your doctor right away if you have very bad diarrhea or diarrhea that will not go away. Call your doctor right away if you have signs of dehydration like very bad dizziness or passing out, not able to pass urine or change in how much urine is passed, or feeling very tired.

What are some other side effects of Juxtapid?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Stomach cramps.
  • Bloating.
  • Feeling tired or weak.
  • Gas.
  • Constipation.
  • Heartburn.
  • Weight loss.
  • Back pain.
  • Nose and throat irritation.
  • Headache.
  • Dizziness.
  • It is common to have diarrhea, upset stomach, throwing up, and stomach pain with Juxtapid (lomitapide). A low-fat diet may help lower the chance of having these side effects. Call your doctor if you any of these side effects is very bad, bothers you, or does not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Juxtapid?

  • Store at room temperature.
  • Keep lid tightly closed.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time Juxtapid (lomitapide) is refilled. If you have any questions about Juxtapid (lomitapide), please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.