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Invirase Tablets

Generic Name: Saquinavir Tablets (sa KWIN a vir)
Brand Name: Invirase

Medically reviewed on Sep 5, 2018

Uses of Invirase:

See also: Atripla

What do I need to tell my doctor BEFORE I take Invirase?

  • If you have an allergy to saquinavir or any other part of Invirase (saquinavir tablets).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Heart block without a working pacemaker, liver disease, or low blood magnesium or potassium levels.
  • If you have ever had a long QT on ECG.
  • If you are not taking ritonavir.
  • If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with Invirase (saquinavir tablets), like certain drugs that are used for high cholesterol, migraines, or mood problems. There are many drugs that must not be taken with Invirase (saquinavir tablets).
  • If you are taking any drugs that can cause a certain type of heartbeat that is not normal (prolonged QT interval). There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.
  • If you have taken a drug that has rilpivirine in it within the past 2 weeks.
  • If you are breast-feeding. Do not breast-feed while you take Invirase (saquinavir tablets).

This is not a list of all drugs or health problems that interact with Invirase (saquinavir tablets).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Invirase (saquinavir tablets) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Invirase?

  • Tell all of your health care providers that you take Invirase (saquinavir tablets). This includes your doctors, nurses, pharmacists, and dentists.
  • This medicine interacts with many other drugs. The chance of Invirase (saquinavir tablets)'s side effects may be raised or how well Invirase (saquinavir tablets) works may be lowered. The chance of the other drugs' side effects may also be raised. This may include very bad, life-threatening, or deadly side effects. Check with your doctor and pharmacist to make sure that it is safe for you to take Invirase (saquinavir tablets) with all of your other drugs (prescription or OTC, natural products, vitamins).
  • A type of abnormal heartbeat (prolonged QT interval) has happened with Invirase (saquinavir tablets). Sometimes, this has led to another type of unsafe abnormal heartbeat (torsades de pointes). Call your doctor right away if you have a fast or abnormal heartbeat, or if you pass out.
  • You may have some heart tests before starting Invirase (saquinavir tablets). Talk with your doctor.
  • High blood sugar has happened with Invirase (saquinavir tablets). This includes diabetes that is new or worse. Talk with the doctor.
  • Check your blood sugar as you have been told by your doctor.
  • Some people with hemophilia have had times of more bleeding when taking drugs like this one. If you have hemophilia, talk with your doctor.
  • If you have liver problems like hepatitis B or C, talk with your doctor. Liver problems have gotten worse with Invirase (saquinavir tablets). Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • This medicine may cause high cholesterol and triglyceride levels. Talk with the doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • This medicine is not a cure for HIV. Stay under the care of your doctor.
  • This medicine does not stop the spread of diseases like HIV or hepatitis that are passed through blood or having sex. Do not have any kind of sex without using a latex or polyurethane condom. Do not share needles or other things like toothbrushes or razors. Talk with your doctor.
  • Birth control pills and other hormone-based birth control may not work as well to prevent pregnancy. Use some other kind of birth control also like a condom when taking Invirase (saquinavir tablets).
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Invirase (saquinavir tablets) while you are pregnant.

How is this medicine (Invirase) best taken?

Use Invirase (saquinavir tablets) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take Invirase (saquinavir tablets) at the same time as ritonavir.
  • Take within 2 hours after a meal.
  • Keep taking Invirase (saquinavir tablets) as you have been told by your doctor or other health care provider, even if you feel well.
  • It is important that you do not miss or skip a dose of Invirase (saquinavir tablets) during treatment.
  • Swallow whole. Do not chew, break, or crush.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.
  • If you are not sure what to do if you miss a dose, call your doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
  • Dizziness.
  • Change in body fat.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
  • Changes in your immune system can happen when you start taking drugs to treat HIV. If you have an infection that you did not know you had, it may show up when you take Invirase (saquinavir tablets). Tell your doctor right away if you have any new signs after you start Invirase (saquinavir tablets), even after taking it for several months. This includes signs of infection like fever, sore throat, weakness, cough, or shortness of breath.

What are some other side effects of Invirase?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Belly pain.
  • Loose stools (diarrhea).
  • Upset stomach or throwing up.
  • Feeling tired or weak.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Invirase?

  • Store at room temperature.
  • Keep lid tightly closed.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time Invirase (saquinavir tablets) is refilled. If you have any questions about Invirase (saquinavir tablets), please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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