Skip to Content

The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content.

Infumorph solution

Generic Name: morphine (MORE-feen)
Brand Name: Infumorph

Infumorph solution is usually administered through special infusion equipment. Because Infumorph solution is concentrated, it is not intended for single-dose intravenous, intramuscular, or subcutaneous administration. Do not use Infumorph solution in place of other forms of morphine. Doing any of these things could result in accidental overdose, which can cause seizures, severe breathing problems, and possibly death.

Administration of the first dose of Infumorph solution, as well as any refilling or maintenance of infusion equipment, should be performed in a health care facility where naloxone injection and resuscitative equipment are available. Patients should be observed in such a health care setting for at least 24 hours after receiving the initial dose of Infumorph solution and for the first several days after intrathecal catheter implantation, as appropriate.

If you accidentally get Infumorph solution on your skin or clothing, remove the contaminated clothing and rinse your skin well with water.

Infumorph solution is used for:

Treating chronic pain, usually after other treatments have not been adequate.

Infumorph solution is a narcotic pain reliever. It works by dulling the pain perception center in the brain. It may also affect other body systems (eg, breathing and circulatory systems) at higher doses.

Do NOT use Infumorph solution if:

  • you are allergic to any ingredient in Infumorph solution
  • you are taking cimetidine, sodium oxybate (GHB), or a tricyclic antidepressant (eg, amitriptyline), or you drink alcohol
  • you have known or suspected paralysis of the intestines or antibiotic-associated colitis
  • you have diarrhea due to poisoning
  • you have an upper airway (breathing) obstruction or low blood volume, or you are having an asthma attack

Contact your doctor or health care provider right away if any of these apply to you.

Before using Infumorph solution:

Some medical conditions may interact with Infumorph solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have asthma, chronic obstructive pulmonary disease (COPD), or other lung or breathing problems, or you have a history of drug abuse or dependence
  • if you have increased pressure in the head, a recent head injury, or lesions in the head
  • if you have heart, liver, or thyroid disease; curvature of the spine; seizures; or a history of suicidal thoughts or behaviors
  • if you have a stomach blockage or inflammatory bowel disease, or you recently had stomach tract surgery

Some MEDICINES MAY INTERACT with Infumorph solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Fluoxetine, naltrexone, rifampin, or risperidone because they may decrease Infumorph solution's effectiveness
  • Barbiturate anesthetics (eg, thiopental), cimetidine, ethanol, ketorolac, sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because side effects (eg, disorientation, respiratory depression, seizures) may occur
  • Barbiturate anesthetics (eg, thiopental) or sodium oxybate (GHB) because the risk of their side effects may be increased by Infumorph solution
  • Mexiletine or trovafloxacin because their effectiveness may be decreased by Infumorph solution

This may not be a complete list of all interactions that may occur. Ask your health care provider if Infumorph solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Infumorph solution:

Use Infumorph solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Infumorph solution is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Infumorph solution at home, a health care provider will teach you how to use it. Be sure you understand how to use Infumorph solution. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Infumorph solution if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • If you miss a dose of Infumorph solution and you are using it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Infumorph solution.

Important safety information:

  • Infumorph solution may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Infumorph solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Infumorph solution; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • The risk of Infumorph solution becoming habit-forming may be greater if you take it in high doses or for a long time. Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Tell your doctor or dentist that you take Infumorph solution before you receive any medical or dental care, emergency care, or surgery.
  • Do not use Infumorph solution if you have had a severe allergic reaction to morphine or hydromorphone (eg, MS Contin, Roxanol, Dilaudid). If you have a question about whether you are allergic to Infumorph solution or if a certain medicine contains morphine or hydromorphone, contact your doctor or pharmacist.
  • Lab tests, including liver function, kidney function, lung function, and complete blood cell counts, may be performed while you use Infumorph solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Infumorph solution with caution in the ELDERLY; they may be more sensitive to its effects.
  • Infumorph solution should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Infumorph solution while you are pregnant. Infumorph solution is found in breast milk. Do not breast-feed while taking Infumorph solution.

When used for long periods of time or at high doses, Infumorph solution may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Infumorph solution stops working well. Do not take more than prescribed.

Some people who use Infumorph solution for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction. If you stop taking Infumorph solution suddenly, you may have WITHDRAWAL symptoms. These may include anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping.

Possible side effects of Infumorph solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Agitation; anxiety; changes in vision; confusion; constipation; decreased sex drive; dizziness; drowsiness; dry mouth; exaggerated sense of well-being; fear; frequent urination; headache; incoordination; lack of energy; lightheadedness; loss of appetite; mental clouding; mood swings; nausea; pinpoint pupils; restless mood; sleeplessness; sweating; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); delirium; difficulty urinating; disorientation; fainting; fast or slow heartbeat; flushing of the face; hallucinations; pounding in the chest; seizures; slowed breathing; tremor; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include cold and clammy skin; convulsions; deep sleep; dizziness; drowsiness; lightheadedness; loss of consciousness; slowed breathing; slowed heartbeat.

Proper storage of Infumorph solution:

Infumorph solution is usually handled and stored by a health care provider. If you are using Infumorph solution at home, store Infumorph solution as directed by your pharmacist or health care provider. Keep Infumorph solution out of the reach of children and away from pets.

General information:

  • If you have any questions about Infumorph solution, please talk with your doctor, pharmacist, or other health care provider.
  • Infumorph solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Infumorph solution or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Infumorph solution. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Infumorph solution. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Infumorph solution.

Issue Date: June 3, 2015

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.