Ifex (Injection Kit)
Generic Name: Ifosfamide and Mesna Injection Kit (eye FOS fa mide/MES na)
Brand Name: Ifex, Mesnex
Medically reviewed: April 4, 2018
- This medicine may lower the ability of your bone marrow to make blood cells that your body needs. This can lead to needing a blood transfusion and very bad and sometimes deadly bleeding problems or infections. Tell your doctor right away if you have signs of infection like fever, chills, or sore throat; any bruising or bleeding; or if you feel very tired or weak.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- This medicine may cause blood in the urine and bladder pain. Talk with the doctor.
- This medicine may cause kidney problems in some patients. Talk with the doctor.
- This medicine may cause very bad and sometimes deadly nervous system problems. These include brain problems, hallucinations, and confusion. Sometimes, people have fallen into a coma. Nervous system problems may start within a few hours after getting Ifex (ifosfamide and mesna injection kit) and may last for 2 to 3 days after stopping it. Talk with the doctor.
- You will be watched closely by your doctor.
Uses of Ifex:
- It is used to treat cancer.
- It is used to lower the bad effects of some cancer drugs on the bladder.
What do I need to tell my doctor BEFORE I take Ifex?
- If you have an allergy to ifosfamide, mesna, or any other part of Ifex (ifosfamide and mesna injection kit).
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you are not able to pass urine.
This is not a list of all drugs or health problems that interact with Ifex (ifosfamide and mesna injection kit).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Ifex (ifosfamide and mesna injection kit) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Ifex?
- Tell all of your health care providers that you take Ifex (ifosfamide and mesna injection kit). This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for you to be alert until you see how Ifex (ifosfamide and mesna injection kit) affects you.
- Have your urine checked as you have been told by your doctor.
- Talk with your doctor before getting any vaccines. Use with Ifex (ifosfamide and mesna injection kit) may either raise the chance of an infection or make the vaccine not work as well.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
- If you have high blood sugar (diabetes), some urine ketone tests may be wrong. Talk with your doctor.
- If you have upset stomach, throwing up, loose stools (diarrhea), or are not hungry, talk with your doctor. There may be ways to lower these side effects.
- Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions.
- This medicine may raise the chance of a very bad and sometimes deadly heart problem. Talk with the doctor.
- Other types of cancer may rarely happen later in life.
- If you drink grapefruit juice or eat grapefruit often, talk with your doctor.
- Pass urine often. You need to empty your bladder often. Drinking lots of liquids will help.
- To help with mouth sores, use a soft toothbrush or cotton swabs and rinse the mouth. Do not use mouth rinses that have alcohol in them.
- If you are 65 or older, use Ifex (ifosfamide and mesna injection kit) with care. You could have more side effects.
- Some products have benzyl alcohol. Do not give a product that has benzyl alcohol in it to a newborn or infant. Talk with the doctor to see if this product has benzyl alcohol in it.
- This medicine may cause you to not be able to get pregnant. Talk with the doctor.
- This medicine may affect sperm in men. This may affect being able to father a child. Talk with the doctor.
- Use birth control that you can trust to prevent pregnancy while taking Ifex (ifosfamide and mesna injection kit) and for 6 months after stopping Ifex (ifosfamide and mesna injection kit).
- If you are a man and have sex with a female who could get pregnant, protect her from pregnancy during care and for 6 months after care ends. Use birth control that you can trust.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Ifex (ifosfamide and mesna injection kit) while you are pregnant.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
How is this medicine (Ifex) best taken?
Use Ifex (ifosfamide and mesna injection kit) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as a shot into a vein over a period of time.
- Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
- Very bad back pain.
- Chest pain or pressure or a fast heartbeat.
- A heartbeat that does not feel normal.
- Feeling sleepy.
- Feeling confused.
- Change in the way you act.
- Feeling very tired or weak.
- Dark urine or yellow skin or eyes.
- Very bad belly pain.
- Hallucinations (seeing or hearing things that are not there).
- Shortness of breath, a big weight gain, or swelling in the arms or legs.
- Mouth irritation or mouth sores.
- Skin wound that will not heal.
- Change in eyesight, eye pain, or very bad eye irritation.
- Hearing loss.
- Ringing in ears.
- For women, no period.
- Very bad and sometimes deadly lung or breathing problems have happened with Ifex (ifosfamide and mesna injection kit). Call your doctor right away if you have lung or breathing problems like trouble breathing, shortness of breath, or a cough that is new or worse.
What are some other side effects of Ifex?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Loose stools (diarrhea).
- Hard stools (constipation).
- Feeling sleepy.
- Not hungry.
- Hair loss.
- Upset stomach or throwing up.
- Irritation where the shot is given.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Ifex?
- If you need to store Ifex (ifosfamide and mesna injection kit) at home, talk with your doctor, nurse, or pharmacist about how to store it.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Ifex (ifosfamide and mesna injection kit), please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about ifosfamide/mesna
- Side Effects
- During Pregnancy
- Drug Interactions
- Support Group
- 0 Reviews – Add your own review/rating
- Drug class: alkylating agents