Hydrocodone and Guaifenesin
Medically reviewed on May 2, 2018
WarningFor all patients taking this medicine:
- This medicine has an opioid drug in it. Opioid drugs can put you at risk for addiction, abuse, and misuse. Misuse or abuse of hydrocodone and guaifenesin can lead to overdose and death. If you have questions, talk with your doctor.
- This medicine has an opioid drug in it. The use of opioid drugs along with a benzodiazepine drug or other drugs that may make you drowsy or slow your actions has led to very bad side effects. Side effects that have happened include slowed or trouble breathing and deaths. Benzodiazepine drugs include drugs like alprazolam, diazepam, and lorazepam. Benzodiazepine drugs are used to treat many health problems like anxiety, trouble sleeping, or seizures. Talk with the doctor.
- Many drugs interact with hydrocodone and guaifenesin and can raise the chance of side effects like deadly breathing problems. Talk with your doctor and pharmacist to make sure it is safe to use hydrocodone and guaifenesin with all of your drugs.
- Avoid alcohol or other drugs and natural products that slow your actions.
- Get medical help right away if you feel very sleepy, very dizzy, or if you pass out. Caregivers or others need to get medical help right away if the patient does not respond, does not answer or react like normal, or will not wake up.
- Very bad and sometimes deadly breathing problems have happened with hydrocodone and guaifenesin. Talk with the doctor.
- Get medical help right away if you have slow breathing, shallow breathing, or trouble breathing.
- This medicine is not for use in children younger than 18 years of age. The benefits of taking hydrocodone and guaifenesin for a cough due to allergies, a cold, or other infection do not outweigh the risks in children. If your child has been given hydrocodone and guaifenesin or if you have any questions, talk with your child's doctor.
Uses of Hydrocodone and Guaifenesin:
- It is used to thin mucus so it can be taken from the body by coughing.
- It is used to relieve coughing.
What do I need to tell my doctor BEFORE I take Hydrocodone and Guaifenesin?
- If you have an allergy to hydrocodone and guaifenesin or any part of hydrocodone and guaifenesin.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have a cough with a lot of mucous.
- If you have a long-term cough caused by smoking or being around smoke, or lung problems like asthma or emphysema.
- If you have had a recent head injury, brain injury or tumor, or raised pressure in the brain.
- If you have taken certain drugs used for low mood (depression) like isocarboxazid, phenelzine, or tranylcypromine or drugs used for Parkinson's disease like selegiline or rasagiline in the last 14 days. Taking hydrocodone and guaifenesin within 14 days of those drugs can cause very bad high blood pressure.
- If you are taking any of these drugs: Linezolid or methylene blue.
This is not a list of all drugs or health problems that interact with hydrocodone and guaifenesin.
Tell the doctor and pharmacist about all of your child's drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for your child to take hydrocodone and guaifenesin with all of his/her drugs and health problems. Do not start, stop, or change the dose of any drug your child takes without checking with the doctor.
What are some things I need to know or do while I take Hydrocodone and Guaifenesin?
- Tell all of your health care providers that you take hydrocodone and guaifenesin. This includes your doctors, nurses, pharmacists, and dentists.
- Do not take more than what your doctor told you to take. Taking more than you are told may raise your chance of very bad side effects.
- Do not take hydrocodone and guaifenesin for longer than you were told by your doctor.
- Avoid driving and doing other tasks or actions that call for alertness while you take hydrocodone and guaifenesin. Talk with your doctor.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
- This medicine may be habit-forming with long-term use.
- If you have been taking hydrocodone and guaifenesin on a regular basis and you stop it all of a sudden, you may have signs of withdrawal. Do not stop taking hydrocodone and guaifenesin all of a sudden without calling your doctor. Tell your doctor if you have any bad effects.
- Do not take hydrocodone and guaifenesin with other strong pain drugs or if you are using a pain patch without talking to your doctor first.
- Keep away from children. Accidental exposure may cause death. If a child takes hydrocodone and guaifenesin by accident, get medical help right away.
- This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take hydrocodone and guaifenesin.
- If you are 65 or older, use hydrocodone and guaifenesin with care. You could have more side effects.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using hydrocodone and guaifenesin while you are pregnant.
- Using hydrocodone and guaifenesin for a long time during pregnancy may lead to withdrawal in the newborn baby. This can be life-threatening. Talk with the doctor.
- Tell your doctor if you are breast-feeding or plan to breast-feed. This medicine passes into breast milk and may harm your baby.
How is this medicine (Hydrocodone and Guaifenesin) best taken?
Use hydrocodone and guaifenesin as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take with or without food. Take with food if it causes an upset stomach.
- Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
- Measure liquid doses carefully. Use the measuring device that comes with hydrocodone and guaifenesin. If there is none, ask the pharmacist for a device to measure hydrocodone and guaifenesin.
What do I do if I miss a dose?
- If you take hydrocodone and guaifenesin on a regular basis, take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
- Many times hydrocodone and guaifenesin is taken on an as needed basis. Do not take more often than told by the doctor.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child's doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Very bad dizziness or passing out.
- Chest pain or pressure or a fast heartbeat.
- Trouble breathing, slow breathing, or shallow breathing.
- Feeling confused.
- A heartbeat that does not feel normal.
- Hallucinations (seeing or hearing things that are not there).
- Mood changes.
- Very bad belly pain.
- Very bad headache.
- Trouble passing urine.
- Change in eyesight.
- Very upset stomach or throwing up.
- Very hard stools (constipation).
- Feeling very tired or weak.
- Feeling very sleepy.
What are some other side effects of Hydrocodone and Guaifenesin?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Hard stools (constipation).
- Loose stools (diarrhea).
- Feeling sleepy.
- Hot flashes.
- Upset stomach or throwing up.
- Sweating a lot.
- Feeling tired or weak.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Hydrocodone and Guaifenesin?
- Store at room temperature.
- Protect from light.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time hydrocodone and guaifenesin is refilled. If you have any questions about hydrocodone and guaifenesin, please talk with the doctor, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
- This information should not be used to decide whether or not to take hydrocodone and guaifenesin or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about hydrocodone and guaifenesin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to hydrocodone and guaifenesin. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using hydrocodone and guaifenesin.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about guaifenesin/hydrocodone
- Guaifenesin/hydrocodone Side Effects
- During Pregnancy
- Drug Interactions
- Support Group
- 3 Reviews – Add your own review/rating
- Drug class: upper respiratory combinations