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Gengraf (Oral Solution, Modified)

Generic Name: Cyclosporine Oral Solution, Modified (SYE kloe SPOR in)
Brand Name: Gengraf, Neoral

Medically reviewed on September 5, 2018

Warning

  • You may have more of a chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu. Some infections have been very bad and even deadly.
  • Lymphoma and other cancers have happened in people who take Gengraf (cyclosporine oral solution, modified) or drugs like it. This has been deadly in some cases. Talk with the doctor.
  • If Gengraf (cyclosporine oral solution, modified) is given with other drugs that work on the immune system, it can add to the chance of getting an infection or lymphoma or other cancers. Call your doctor right away if you have a change in color or size of a mole; a lump in the armpit, groin, or neck; or any new or changing skin lump or growth. Talk with the doctor.
  • Call your doctor right away if you have any signs of infection like fever, chills, flu-like signs, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or a wound that will not heal.
  • This medicine may cause kidney problems in some patients. Talk with the doctor.
  • High blood pressure has happened with Gengraf (cyclosporine oral solution, modified). Have your blood pressure checked as you have been told by your doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • There is more than 1 brand of Gengraf (cyclosporine oral solution, modified). One brand cannot safely be used for the other. The doctor will tell you about any needed change.
  • If you are taking Gengraf (cyclosporine oral solution, modified) for psoriasis AND you have used other drugs or radiation to treat this health problem before, your chance of skin cancer may be higher.

Uses of Gengraf:

See also: Stelara
  • It is used to keep the body from harming the organ after an organ transplant.
  • It is used to treat rheumatoid arthritis.
  • It is used to treat very bad psoriasis.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Gengraf?

For all patients taking Gengraf (cyclosporine oral solution, modified):

  • If you have an allergy to cyclosporine or any other part of Gengraf (cyclosporine oral solution, modified).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Cancer, kidney problems, or high blood pressure.
  • If you are taking any of these drugs: Aliskiren, amiloride, bosentan, dabigatran, orlistat, spironolactone, or triamterene.
  • If you are breast-feeding or plan to breast-feed.

Psoriasis:

  • If you have psoriasis and are using other treatments like other drugs or radiation.

This is not a list of all drugs or health problems that interact with Gengraf (cyclosporine oral solution, modified).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Gengraf (cyclosporine oral solution, modified) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Gengraf?

  • Tell all of your health care providers that you take Gengraf (cyclosporine oral solution, modified). This includes your doctors, nurses, pharmacists, and dentists.
  • If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
  • If you are taking a salt substitute that has potassium in it, a potassium-sparing diuretic, or a potassium product, talk with your doctor.
  • This medicine has alcohol in it. Talk with the doctor.
  • This medicine interacts with many other drugs. The chance of Gengraf (cyclosporine oral solution, modified)'s side effects may be raised or how well Gengraf (cyclosporine oral solution, modified) works may be lowered. The chance of the other drugs' side effects may also be raised. This may include very bad, life-threatening, or deadly side effects. Check with your doctor and pharmacist to make sure that it is safe for you to take Gengraf (cyclosporine oral solution, modified) with all of your other drugs (prescription or OTC, natural products, vitamins).
  • The chance of skin cancer may be raised. Avoid lots of sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
  • Have your skin checked as you have been told by your doctor. Talk with your doctor.
  • Some people treated with Gengraf (cyclosporine oral solution, modified) have had very bad kidney problems caused by a certain viral infection (BK virus). In people who have had a kidney transplant, BK virus infection may cause loss of the kidney. Call your doctor right away if you have signs of kidney problems like change in the amount of urine passed, difficulty or pain when passing urine, or blood in the urine.
  • A very bad and sometimes deadly brain problem called posterior reversible encephalopathy syndrome (PRES) has happened with Gengraf (cyclosporine oral solution, modified). Call your doctor right away if you have signs like feeling confused, lowered alertness, change in eyesight, loss of eyesight, seizures, or very bad headache.
  • Talk with your doctor before getting any vaccines. Use with Gengraf (cyclosporine oral solution, modified) may either raise the chance of an infection or make the vaccine not work as well.
  • Take good care of your teeth. See a dentist often.
  • Avoid grapefruit and grapefruit juice.
  • Watch for gout attacks.
  • If you are 65 or older, use Gengraf (cyclosporine oral solution, modified) with care. You could have more side effects.
  • Use with care in children. Talk with the doctor.
  • This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking Gengraf (cyclosporine oral solution, modified), call your doctor right away.

How is this medicine (Gengraf) best taken?

Use Gengraf (cyclosporine oral solution, modified) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with or without food but take the same way each time. Always take with food or always take on an empty stomach.
  • If you are taking sirolimus, take it 4 hours after taking Gengraf (cyclosporine oral solution, modified).
  • To gain the most benefit, do not miss doses.
  • Keep taking Gengraf (cyclosporine oral solution, modified) as you have been told by your doctor or other health care provider, even if you feel well.
  • Take Gengraf (cyclosporine oral solution, modified) at the same time of day.
  • Measure liquid doses carefully. Use the measuring device that comes with Gengraf (cyclosporine oral solution, modified).
  • Do not rinse the syringe that comes with Gengraf (cyclosporine oral solution, modified) before or after you take your dose. If you need to wash it, be sure it is completely dry before you use it again.
  • Mix solution in glass with orange or apple juice at room temperature and drink it right away. Rinse glass with more liquid and drink.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Signs of electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, seizures, not hungry, or very bad upset stomach or throwing up.
  • Any unexplained bruising or bleeding.
  • A burning, numbness, or tingling feeling that is not normal.
  • Chest pain or pressure or a fast heartbeat.
  • Gum changes.
  • Hearing loss.
  • Shortness of breath.
  • Shakiness.
  • Swelling.
  • Very bad and sometimes deadly liver problems have happened with Gengraf (cyclosporine oral solution, modified). Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • A very bad brain problem called progressive multifocal leukoencephalopathy (PML) has happened with Gengraf (cyclosporine oral solution, modified). It may cause disability or can be deadly. Tell your doctor right away if you have signs like confusion, memory problems, low mood (depression), change in the way you act, change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or change in eyesight.

What are some other side effects of Gengraf?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Headache.
  • Loose stools (diarrhea).
  • Hair growth.
  • Pimples (acne).
  • Dizziness.
  • Upset stomach or throwing up.
  • Flushing.
  • Belly pain.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Gengraf?

  • Store at room temperature. Do not refrigerate or freeze.
  • Store in original container.
  • After opening, throw away any part not used after 60 days.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Gengraf (cyclosporine oral solution, modified), please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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